Electrically conducting collagen and collagen–mineral composites for current stimulation

Abstract

Electrochemical aggregation of (a) collagen–PEDOT:PSS and (b) collagen–calcium phosphate–PEDOT:PSS.

Biological properties of calcium phosphate biomaterials for bone repair: a review

“…54 As one of the most abundant structural proteins in hard tissues and a well-known mediator of osteoblast cellular functions such as initial attachment, proliferation, and differentiation, 129 collagen has been widely explored as a coating on calcium phosphate scaffolds, including unmodied/modied microporous BCP 130 and HA. 129,131 Although these various coatings provide the scaffold with the unique enhancement of different properties such as improved osteoinductivity and adsorption of bone morphogenetic proteins, some coating solutions used for impregnating scaffolds may lead to the considerably decreased porosity of the scaffold, due to the high viscosity, which could impact the ingrowth of bone cells into the scaffold. 132 Thus, further research is necessary to deal with the problems caused by sticky coating solutions.…”

Pulsed Electrical Stimulation Enhances Body Fluid Transport for Collagen Biomineralization

“…For example, application of medical microbots may accurately control electrical stimulation in the targeted area at the microscale . Installing small piezoelectric or triboelectric devices ,− and injecting a conductive bioscaffold − are also future options to utilize biologically generated pulsed electricity for bone regeneration. Photoactivated materials can be alternatively used with pulsed irradiation to stimulate osteogenic differentiation by simulating biogenerated electric conditions in physiologic systems .…”

Assessment of the interacting mechanism between Candida rugosa lipases and hydroxyapatite and identification of the hydroxyapatite-binding sequence through proteomics and molecular modelling

“…Specic topographic pattern of HAP suggests at least three distinct interaction patterns in theory: cation-exchange of -NH 2 groups in basic proteins with P-sites, specic metal chelation and anion-exchange of -COOH clusters in acidic proteins with C-sites, as well as hydrogen bonds with OH-groups. [12][13][14] Apart from these most probable interaction patterns, in our earlier work, we have observed hydrophobic interactions of lipase A from Candida antarctica (CAL A) and hydroxyapatite, which was successfully employed for one-step, high-yield purication of this enzyme. 9 In reality however, protein binding is multifactorial process, governed by the characteristics of both the carrier and protein itself.…”