Electrically-elicited surface mechanomyogram in myotonic dystrophy

Orizio, Claudio; Esposito, Fabio; Paganotti, I; Marino, L.; Rossi, Bruno; Veicsteinas, Arsenio

doi:10.1007/bf02080462

Cited by 50 publications

(75 citation statements)

References 15 publications

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“…In agreement with previous investigations [35,36], maximum electrically evoked and voluntary strength were significantly lower in DM1 than in HC in both muscles. Lower EMG and MMG amplitude parameters values accompanied this force deficit in patients with DM1.…”

Section: Emg Mmg and F Parameterssupporting

confidence: 93%

“…Based on previous investigations by our group [35,36] and on preliminary data, a sample size of 13 participants was selected to ensure a statistical power higher than 0.80, with a type 1 error <0. [38].…”

Section: Discussionmentioning

confidence: 99%

“…Lower EMG and MMG amplitude parameters values accompanied this force deficit in patients with DM1. Collectively, the DM1-induced alteration in Ca 2+ release, the reduction in the number of efficient motor units, as witnessed by the lower EMG and MMG amplitude, and the increased fibrosis and adipose deposition may all concur to explain the reduction in force [5,35,36].…”

Section: Emg Mmg and F Parametersmentioning

confidence: 99%

“…The longer t EMG-MMG in DM1 may be explained by the alteration in the splicing of several proteins, such as SERCA1 and CACNA1S, involved in Ca 2+ homeostasis and in excitation-contraction coupling mechanism [6][7][8][9][10] thus possibly leading to a lengthened duration of the dihydropyridine and ryanodine receptors interaction, Ca 2+ release by sarcoplasmic reticulum, and troponin activation [9,10,35].…”

Section: Delays During Muscle Contractionmentioning

confidence: 99%

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Electromechanical delay components during skeletal muscle contraction and relaxation in patients with myotonic dystrophy type 1

Esposito

Cè

Rampichini

et al. 2016

Neuromuscular Disorders

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights Patients with myotonic dystrophy type 1 (DM1) were investigated isometrically  We calculated the electromechanical delays during muscle contraction and relaxation  Delays were partitioned into electrochemical and mechanical components  Measurements reliability was very high in both patients and controls  Delays were longer in DM1, especially during muscle relaxation AbstractThe electromechanical delay during muscle contraction and relaxation can be partitioned into mainly electrochemical and mainly mechanical components by an EMG, mechanomyographic, and force combined approach. Components duration and measurements reliability were investigated during contraction and relaxation in a group of patients with myotonic dystrophy type 1 (DM1, n=13) and in healthy controls (n=13). EMG, mechanomyogram, and force were recorded in DM1 and in age-and body-matched controls from tibialis anterior (distal muscle) and vastus lateralis (proximal muscle) muscles during maximum voluntary and electrically-evoked isometric contractions. The electrochemical and mechanical components of the electromechanical delay during muscle contraction and relaxation were calculated off-line. Maximum strength was significantly lower in DM1 than in controls under both experimental conditions. All electrochemical and mechanical components were significantly longer in DM1 in both muscles.Measurements reliability was very high in both DM1 and controls. The high reliability of the measurements and the differences between DM1 patients and controls suggest that the EMG, mechanomyographic, and force combined approach could be utilized as a valid tool to assess the level of neuromuscular dysfunction in this pathology, and to follow the efficacy of pharmacological or non-pharmacological interventions.

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Section: Emg Mmg and F Parameterssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Emg Mmg and F Parametersmentioning

confidence: 99%

Section: Delays During Muscle Contractionmentioning

confidence: 99%

See 2 more Smart Citations

Electromechanical delay components during skeletal muscle contraction and relaxation in patients with myotonic dystrophy type 1

Esposito

Cè

Rampichini

et al. 2016

Neuromuscular Disorders

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show abstract

“…The illustrative placement using MMG sensors and EMG electrodes is represented in Figure 7 where the MMG sensor is positioned between the EMG electrodes; this placement results in increasing the distance between the electrodes, therefore, they were cut proximally to make them as close as possible. Orizio et al (1997) defines "electromechanical delay" (EMD) as the time interval between the instants at which the EMG and the MMG surpassed the threshold of their average resting values (three standard deviations). In other words, the EMD is the existing time delay between the onset of neuromuscular electrical activation, mechanical myofiber activation and the onset of force development.…”

Section: Clinical Assessment and Rehabilitation Biofeedbackmentioning

confidence: 99%

Advances and perspectives of mechanomyography

Krueger

Scheeren

Nogueira-Neto

et al. 2014

Rev. Bras. Eng. Bioméd.

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Introduction: The evaluation of muscular tissue condition can be accomplished with mechanomyography (MMG), a technique that registers intramuscular mechanical waves produced during a fi ber's contraction and stretching that are sensed or interfaced on the skin surface. Objective: Considering the scope of MMG measurements and recent advances involving the technique, the goal of this paper is to discuss mechanomyography updates and discuss its applications and potential future applications. Methods: Forty-three MMG studies were published between the years of 1987 and 2013. Results: MMG sensors are developed with different technologies such as condenser microphones, accelerometers, laser-based instruments, etc. Experimental protocols that are described in scientifi c publications typically investigated the condition of the vastus lateralis muscle and used sensors built with accelerometers, third and fourth order Butterworth fi lters, 5-100Hz frequency bandpass, signal analysis using Root Mean Square (RMS) (temporal), Median Frequency (MDF) and Mean Power Frequency (MPF) (spectral) features, with epochs of 1 s. Conclusion: Mechanomyographic responses obtained in isometric contractions differ from those observed during dynamic contractions in both passive and functional electrical stimulation evoked movements. In the near future, MMG features applied to biofeedback closed-loop systems will help people with disabilities, such as spinal cord injury or limb amputation because they may improve both neural and myoelectric prosthetic control. Muscular tissue assessment is a new application area enabled by MMG; it can be useful in evaluating the muscular tonus in anesthetic blockade or in pathologies such as myotonic dystrophy, chronic obstructive pulmonary disease, and disorders including dysphagia, myalgia and spastic hypertonia. New research becomes necessary to improve the effi ciency of MMG systems and increase their application in rehabilitation, clinical and other health areas.

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The effect of leg extension training on the mean power frequency of the mechanomyographic signal

et al. 2000

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Electrically-elicited surface mechanomyogram in myotonic dystrophy

Abstract: The differences between the MMGs of MyD patients and C support the hypothesis that, together with the well-known changes in sarcolemmal excitability, an alteration in electromechanical coupling and a failure in contractile machinery may coexist in MyD.

Cited by 50 publications

References 15 publications

Electromechanical delay components during skeletal muscle contraction and relaxation in patients with myotonic dystrophy type 1

Electromechanical delay components during skeletal muscle contraction and relaxation in patients with myotonic dystrophy type 1

Advances and perspectives of mechanomyography

The effect of leg extension training on the mean power frequency of the mechanomyographic signal

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