Electro-oxidative C–H amination of heteroarenes with aniline derivatives via radical–radical cross coupling

Abstract

The selectively synthesis of C-2/C-3 aminated five-membered heteroarenes incorporated various functionalities with aniline derivatives in a sustainable way remains an unmet challenge. This protocol presents a practical protocol for C–H...

Electrochemical [3+2] Cycloaddition of Anilines and 1,3‐Dicarbonyl Compounds: Construction of Multisubstituted Indoles

“…The adduct, 6 a , was detected using high‐resolution mass spectroscopy (HRMS), indicating the formation of the β‐dicarbonyl radical intermediate. In addition, adducts 6 b and 6 c were also detected using HRMS (Schemes 4b and 4c), which indicated that a nitrogen radical was generated and subsequently transformed into a carbon radical [11c,17] . Moreover, it should be noted that 6 d was obtained by slightly varying the reaction conditions (Scheme 4d).…”

Design, Synthesis, Insecticidal Activities and Molecular Docking of Sulfonamide Derivatives Containing Propargyloxy or Pyridine Groups

“…Given our previous work and above points, a series of sulfonamide derivatives containing propargyloxy group were synthesized by inverting sulfonamide with N ‐butyl‐4‐propargyloxybenzenesulfonamide as the lead compound, and a series of sulfonamide derivatives containing pyridine skeleton were designed by combination principle in this study ( Figure 1). In this article, a total of thirty‐seven compounds were designed and synthesized, among which compounds A5, A9 and C7‐C9 have been reported in the literature [25–28] . Subsequently, the insecticidal activities of the designed compounds were tested and their structure–activity relationships were carefully explored to provide new ideas for the design and synthesis of insecticides.…”

Electrochemical Difunctionalization of gem-Difluoroalkenes: A Metal-Free Synthesis of α-Difluoro(alkoxyl/azolated) Methylated Ethers

“…Following our consistent interest in developing practical and operationally simple synthetic methods to gain valuable organic synthons, we envisaged whether we could apply a stepwise electrochemical oxidation to achieve difunctionalization of gem -difluoroalkenes with different nucleophiles under metal-catalyst- and chemical-oxidant-free conditions (Scheme c). Meanwhile, organic electrochemical synthesis has been recognized as environmentally benign and a practical synthetic tool, and several seminal works for the electrochemical difunctionalization of alkenes have been demonstrated .…”