Electroactive and Nanostructured Polymers as Scaffold Materials for Neuronal and Cardiac Tissue Engineering

Li, Mengyan; Bidez, Paul R.; Guterman-Tretter, Elizabeth; Guo, Yi; MacDiarmid, Alan G.; Lelkes, Peter I.; Yuan, Xubo; Yuan, Xiaoyan; Sheng, Jing; Li, Hua; Song, Cun-xian; Wei, Yen

doi:10.1142/s0256767907002199

Cited by 43 publications

(13 citation statements)

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“…5,6 A plethora of approaches can be conducted to increase the surface hydrophilicity and biofunctionality of the PANi-based fibers. Treating with plasma, 7 tethering biological moieties to the surface 8 and coating with more hydrophilic polymers 9 can be taken account of possible approaches.…”

Section: Introductionmentioning

confidence: 99%

Particle‐coated electrospun scaffold: A semi‐conductive drug eluted scaffold with layered fiber/particle arrangement

Khorshidi

Karkhaneh

2018

J Biomedical Materials Res

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In this study, an antibacterial fiber/particle scaffold with improved hydrophilicity has been fabricated. To this end, polyaniline (PANi)/polycaprolactone (PCL) was processed to fibers via electrospinning. Thereafter, ciprofloxacin was loaded in oxidized alginate/gelatin mixture. The mixture was then electrosprayed onto PANi‐based fibers. After particle solidification, oxidized alginate and gelatin simultaneously were crosslinked and encapsulated the ciprofloxacin. The particle/fiber scaffold enabled controlled release of ciprofloxacin. Moreover, the scaffold offered a semi‐conductive structure in which the conductive fibers were interrupted by insulating particles. The scaffold proved higher hydrophilicity, better cell adhesion and proliferation compared with the pristine fibers. Furthermore, the scaffold demonstrated extensive antibacterial activity against gram positive and gram negative bacteria tested. The construct with layered fiber/particle arrangement and benefited from electrical semi‐conductivity, relevant surface hydrophilicity and controlled release of an antibacterial component can be a potent nerve tissue engineering scaffold. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3248–3254, 2018.

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Section: Introductionmentioning

confidence: 99%

Particle‐coated electrospun scaffold: A semi‐conductive drug eluted scaffold with layered fiber/particle arrangement

Khorshidi

Karkhaneh

2018

J Biomedical Materials Res

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“…Recently, conducting polymers have received a great deal of attention, because direct electrical stimuli or electroactivity of substances can influence cellular behaviors . According to the literature, the conducting polymers such as polypyrrole (PPy) and polyaniline (PANi) enhanced the proliferation and differentiation of neurons, myoblasts, and fibroblasts . Moreover, the conducting polymers were widely studied to scavenge free radicals for their potential in biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/Copolymer Inclusion for Tissue Engineering Repair

Cui

Zhang

et al. 2013

Macromolecular Bioscience

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The injectable electroactive and antioxidant hydrogels are prepared from mixing the tetraaniline functional copolymers and α-cyclodextrin (α-CD) aqueous solution. UV-vis and CV of the copolymer solution showed good electroactive properties. The antioxidant ability of the copolymer is also proved. The gelation mechanism and properties of the system are studied by WAXD, DSC, and rheometer. The encapsulated cells are highly viable in the hydrogels, suggesting that the hydrogels have excellent cytocompatibility. After subcutaneous injection, H&E staining study suggests acceptable biocompatibility of the materials in vivo. Moreover, data shows the injectable electroactive material can effectively accelerate the proliferation of encapsulated cells with electrical stimuli, and the mechanism is also elaborated. Such an injectable electroactive hydrogel would more closely mimic the native extracellular matrix, thereby combining a biomimetic environment of long-term cell survival and electrical signal to support the generation of functional tissue.

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“…Li and coworkers blended polyaniline (PANI), with a natural protein, gelatin, and coelectrospun the blend into nanofibers to investigate its potential application as a conductive scaffold for tissue-engineering purposes [81,82]. They found that the doping of gelatin with a few % of PANI (from 0 to 5%w/w) leads to an alteration of the physicochemical properties of gelatin.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…It was suggested that the biocompatibility of the conductive polymer can be improved by: (i) covalently grafting various adhesive peptides onto the surface of prefabricated conducting polymer films or into the polymer structures during the synthesis, (ii) coelectrospinning or blending with natural proteins to form conducting nanofibers or films, and (iii) preparing conducting polymers using biopolymers, such as collagen, as templates. The work of Li et al describes the approaches of covalently attaching oligopeptides to PANI and electrospinning PANI-gelatin blend nanofibers [82]. The employment of such modified conducting polymers as substrates for enhanced cell attachment, proliferation, and differentiation was investigated with neuronal PC-12 cells and H9c2 cardiac myoblasts.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanostructured Conductive Polymers by Electrospinning

Chronakis

2010

Nanostructured Conductive Polymers

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Electroactive and Nanostructured Polymers as Scaffold Materials for Neuronal and Cardiac Tissue Engineering

Cited by 43 publications

References 0 publications

Particle‐coated electrospun scaffold: A semi‐conductive drug eluted scaffold with layered fiber/particle arrangement

Particle‐coated electrospun scaffold: A semi‐conductive drug eluted scaffold with layered fiber/particle arrangement

In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/Copolymer Inclusion for Tissue Engineering Repair

Nanostructured Conductive Polymers by Electrospinning

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