Electroactive poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) with controllable antifouling and antimicrobial properties

Abstract

A multifunctional zwitterionic PSBEDOT material, which can switch between antifouling and antimicrobial states by controlling the potential of the surface, is synthesized.

Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

“…PSBEDOT and PCBTh can conduct ions, provide excellent anti-fouling properties via zwitterionic side chains, and conduct electrons via conjugated backbones. 36 , 37 Both polymers show great potential for electrochemical biosensing.…”

“…We hypothesized that zwitterionic conjugated polymers can provide a more suitable environment to stabilize the enzyme due to their hydrophilicity and hydration property, and thus prevent biofouling. Herein, as shown in Scheme 1 , we utilized PSBEDOT, which integrates both the conducting and anti-fouling properties, 36 as a matrix for entrapping GOx onto a platinum electrode in a single electropolymerization step. The PSBEDOT–GOx electrode was expected to provide several desired properties for an enzyme-based electrochemical biosensor, including long-term stability, high selectivity and sensitivity, short response time, accurate measurement, stable response in complex media due to superior anti-fouling properties, and enhanced electrical conductivity within one component.…”

Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens

“…More importantly, the CB‐Ring groups can be regenerated in acidic solution to restore their bactericidal ability. In addition, an alternatively approach was also reported to repeatedly tune the bacterial‐killing state and bacterial‐repelling state by applying different electric potentials onto the surface …”

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

“…Meanwhile, the World Health Organization (WHO) has identified a list of the 12 bacteria which pose the greatest threat to human health because they are resistant to antibiotics . Due to the shortage of new drugs in hand to combat multidrug‐resistant bacteria, the recent advancements in the synthesis of antibacterial polymers offered a promising approach to cope with multidrug‐resistant bacteria …”