Electroacupuncture Ameliorates Subchondral Bone Deterioration and Inhibits Cartilage Degeneration in Ovariectomised Rats

Zhou, Jun; Zhong, Peirui; Liao, Ying; Liu, Jing; Liao, Yuan Mei; Xie, Hongyu; Li, Neng; Li, Xinhong; Sun, Guanghua; Zeng, Yahua

doi:10.1136/acupmed-2016-011258

Cited by 13 publications

(15 citation statements)

References 42 publications

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“…Other studies utilizing rodent models of induced OA have found improvements in knee cartilage structure with EA treatment; however, this occurred when EA was administered at the onset of OA, or shortly thereafter. [11][12][13] Although there was no difference in joint scores between groups, our changes in systemic inflammatory mediators and cartilage gene expression still suggest a potential effect of EA in terms of OA disease modification. EA-treated guinea pigs tended to have decreased levels of serum protein C3, a component of the complement cascade.…”

Section: Discussionmentioning

confidence: 64%

Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis

et al. 2021

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Objective: Faced with the frustration of chronic discomfort and restricted mobility due to osteoarthritis (OA), many individuals have turned to acupuncture for relief. However, the efficacy of acupuncture for OA is uncertain, as much of the evidence is inconclusive. The purpose of this study was to evaluate electroacupuncture (EA) in a rodent model of OA such that conclusions regarding its effectiveness for symptom or disease modification could be drawn. Methods: Ten 12-month-old male Hartley guinea pigs—which characteristically have moderate to advanced OA at this age—were randomly assigned to receive EA for knee OA (n = 5) or anesthesia only (control group, n = 5). Treatments were performed three times weekly for 3 weeks, followed by euthanasia 2 weeks later. Gait analysis and enclosure monitoring were performed weekly to evaluate changes in movement. Serum was collected for inflammatory biomarker testing. Knee joints were collected for histology and gene expression. Results: Animals receiving EA had significantly greater changes in movement parameters compared to those receiving anesthesia only. There was a tendency toward decreased serum protein concentrations of complement component 3 (C3) in the EA group compared to the control group. Structural and antioxidant gene transcripts in articular cartilage were increased by EA. There was no significant difference in total joint histology scores between groups. Conclusion: This study provides evidence that EA has a positive effect on symptom, but not disease, modification in a rodent model of OA. Further investigations into mechanistic pathways that may explain the efficacy of EA in this animal model are needed.

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Section: Discussionmentioning

confidence: 64%

Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis

et al. 2021

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“…Previous research suggested that acupuncture showed an obvious effect on analgesia and cartilage protection. 35,36 Our results from experimental OA rats provided a new explanation on the mechanism of acupuncture in treating OA, and the reduced hyperalgesia was related to inhibition of MCP1/CCR2 pathway. We considered that stimulated MCP1/CCR2 axis might up-regulate NGF/TrkA axis which plays an important role in OA pain and take effects through increasing sensory nerve density.…”

Section: Discussionmentioning

confidence: 71%

Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2/CCR2 signaling pathway

et al. 2020

Exp Biol Med (Maywood)

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Acupuncture is an emerging alternative therapy that has been beneficial for the pain of osteoarthritis (OA). However, the underlying mechanism of protective effect remains unclear. MCP1/CCR2 axis can be stimulated in various periods of OA, and we hypothesize that acupuncture may treat OA by regulating the MCP1/CCR2 axis. This study aimed to explore the effect of acupuncture at points ST35 and ST36 on the effects of hyperalgesia and cartilage in OA rats including the expression of chemokines, nerve growth factor (NGF), and inflammatory-related proteins. OA was induced in male Sprague–Dawley rats by anterior cruciate ligament transection at the right knee. The first acupuncture intervention was performed on the seventh day after surgery and once a day for seven weeks. The knee-pain-related behaviors, histology, and related protein were examined in this study. We have found that electroacupuncture at ST35 and ST36 can significantly alleviate the hyperalgesia and cartilage degeneration as well as reducing nerve sprouting in OA knee joint. Moreover, acupuncture treatment may inhibit the MCP1/CCR2 axis as well as down-regulate inflaming factor and NGF in cartilage and synovial tissue. The data presented here indicate that acupuncture exerts a protective effect against hyperalgesia and cartilage degeneration, and the mechanism might involve in chemokines and NGF pathway. Impact statement Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 302 million people worldwide, but the mechanism of OA is far away understood. Acupuncture has been widely used in treating with chronic pain, but how does acupuncture work is still unclear. In this essay, we investigated the molecular target of acupuncture and found new mechanism of the pathogenesis in knee OA. Our results could provide new analgesic mechanisms and find new targets for acupuncture analgesia in OA. In a word, the study can help further understanding and provides more evidence of the clinical use of acupuncture in treating OA.

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“…In the study of POP, because bone remodeling is sustained for approximately 180 to 190 days in basic multicellular units dependent on mechanical micro-injury, [18] using RCT for clinical effect verification may need the long duration of time, costly capital, and lots of manpower and resources. At present, there are many kinds of ACU for the treatment of POP, but various ACU have their characteristics and effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for primary osteoporosis

Fan

Zhao

et al. 2019

Medicine

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Background: A large number of randomized controlled trials (RCTs) have shown that acupuncture (ACU) has certain advantages over pharmacotherapies in the treatment of primary osteoporosis (POP). However, due to the diversity of ACU treatments, its relative effectiveness have not yet been studied and explained. Therefore, based on the network meta-analysis (NMA), this study will compare the differences in the efficacy of multiacupuncture in the treatment of POP, to provide a reference for clinical treatment. Methods: We will search PubMed, MEDLINE, Embase, the Cochrane Library, China National Knowledge Infrastructure (CHKD-CNKI), WANFANG database (Chinese Medicine Premier), Chinese Biomedical Literature database (CBM), and VIP for relevant RCTs of ACU treatments for POP, from their inceptions to January 2019. STATA 15.0 and GEMTC software will be used to perform a NMA. The evidence will be evaluated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach and the type 1 error rate will be assessed by trial sequential analysis (TSA). Results: The results of this review will be submitted to a recognized journal for publication. Conclusion: This proposed systematic review will evaluate the different advantages of various types of ACU in the treatment of POP. Registration: PROSPERO (registration number CRD42019122724).

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Electroacupuncture Ameliorates Subchondral Bone Deterioration and Inhibits Cartilage Degeneration in Ovariectomised Rats

Abstract: The results suggest that EA inhibits subchondral bone loss by regulating RANK/RANKL/OPG signalling and protects articular cartilage by inhibiting MMP-13 in OVX rats.

Cited by 13 publications

References 42 publications

Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis

Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis

Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2/CCR2 signaling pathway

Acupuncture for primary osteoporosis

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