Electroanalytical and surface characterization of encapsulated implantable membrane planar microsensors

Coşofreţ, Vasile V.; Erdősy, Miklós; Johnson, Timothy A.; Bellinger, Dwight A.; Buck, Richard P.; Ash, R. Bruce; Neuman, Michael R.

doi:10.1016/0003-2670(95)00260-7

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…Therefore, physicochemical or biological modi®cation is required to minimize the biofouling after implantation. PolyHEMA was found to act as an effective surface coating [61].…”

Section: Ion Selective Electrodesmentioning

confidence: 99%

Advances in the Microfabrication of Electrochemical Sensors and Systems

Suzuki

2000

Electroanalysis

145

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Technologies to microfabricate electrochemical sensors and systems are rapidly advancing and will surely have an impact on critical fields such as medicine, environment, and information processing. It is a good opportunity to review the state of the art and trends in the technologies developed in this field during the last two decades of the 20th century and prepare for the coming decades. Here, developed electrochemical microsensors and microsystems will be reviewed in terms of techniques and performance along with the problems left as issues for the next century.

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“…Therefore, physicochemical or biological modi®cation is required to minimize the biofouling after implantation. PolyHEMA was found to act as an effective surface coating [61].…”

Section: Ion Selective Electrodesmentioning

confidence: 99%

Advances in the Microfabrication of Electrochemical Sensors and Systems

Suzuki

2000

Electroanalysis

145

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“…The different parameters should be measured simultaneously in a small sample of whole blood. For these reasons, there is a growing interest in designing and developing various types of microfabricated chemical and biochemical sensors in silicon technology [3][4][5][6][7][8]. In our group we have developed a novel sensor platform based on a new type of microfabricated silicon transducers [9-11J.…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biochemical Microsensors in Silicon for the Clinical on-Line Monitoring

Scheipers

Hinkers²,

Wassmus³

et al. 2002

Biomedizinische Technik/Biomedical Engineering

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Miniaturised chemosensors and biosensors for applications in clinical diagnostics and biomedical fields can be fabricated in silicon with high reproducibility using the containment technology. They are characterised by excellent durability of the sensitive membranes. Meanwhile, there are sensors available for a variety of relevant medically parameters such as pH, the blood electrolytes sodium, calcium, potassium, and the blood metabolites glucose and lactate. The miniaturised sensors provide the opportunity to develop product solutions with minimal sampling volume requirements for the "Point of Care (POC)" sector through the combination of innovative microtechnical components. Two examples are presented, such microsystems have been implemented for the medical applications of "Blood Monitoring" and "Glucose Monitoring".

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“…SEM studies have been carried out for membranes based on regenerated silk fibroin for amperometric glucose sensing 3 and for ionselective polyvinylchloride (PVC) membranes for potentiometric sensing. [4][5][6] Usually the PVC membranes are heavily plasticized to accommodate stresses during casting and conditioning. The effect of plasticizers, in turn, can decrease the adhesive strength of the membrane/substrate bond.…”

Section: Introductionmentioning

confidence: 99%

Swelling and delamination of multi-electrode sensor arrays studied by variable-pressure scanning electron microscopy

Lemoine¹,

Mailley²,

Hyland³

et al. 2000

J. Biomed. Mater. Res.

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Multi-electrode sensor arrays are made of soft and wet materials not easily examined by most microscopic techniques. In this paper, we have demonstrated that low-vacuum scanning electron microscopy (LVSEM) and energy-dispersive X-ray analysis (EDX) are adequate for studying the hydration, swelling, and possible delamination of multi-electrode sensor arrays. We found that the LVSEM environment had no detectable effect on the morphology of Na(+), K(+), and Ca(++) sensors, and EDX analysis indicated that all three membranes have similar compositions. However, once hydrated, the sensors exhibited different behaviors. The K(+) and Ca(++) sensors swelled more than the Na(+) sensor did. This swelling is due principally to water sorption in the membrane. We believe that the larger thickness of the K(+) and Ca(++) membrane is partly responsible for the observed swelling effect. A simple Griffith analysis of the interface rupture confirms the experimental evidence that these thicker membranes also are more prone to delamination failure.

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Electroanalytical and surface characterization of encapsulated implantable membrane planar microsensors

Cited by 11 publications

References 27 publications

Advances in the Microfabrication of Electrochemical Sensors and Systems

Advances in the Microfabrication of Electrochemical Sensors and Systems

Chemical and Biochemical Microsensors in Silicon for the Clinical on-Line Monitoring

Swelling and delamination of multi-electrode sensor arrays studied by variable-pressure scanning electron microscopy

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