Electroanalytical Determination of Escitalopram Oxalate Using Nickel Nanoparticles Modified Carbon Paste Sensor

Abstract

A sensitive voltammetric method was described for the determination of escitalopram oxalate based on electrocatalytic oxidation at nickel nanoparticles modified chloranil carbon paste sensor in Britton-Robinson buffer (pH range from 2 to 10). The modified electrode was characterized by scanning electron microscopy, electrochemical impedance and cyclic voltammetry. The investigation of electrochemical behavior of escitalopram oxalate was performed using cyclic voltammetry and differential pulse voltammetry. The anodic peak current showed a linear range from 1.0 × 10 -6 to 7.0 × 10 -5 mol L -1. The detection limit is below 2.0 × 10 -7 mol L -1 . The proposed method is rapid, economical, simple, precise and sensitive voltammetric method for the determination of escitalopram oxalate in bulk, dosage form and urine.

Review on Surface-Modified Electrodes for the Enhanced Electrochemical Detection of Selective Serotonin Reuptake Inhibitors (SSRIs)

“…An array of nanoparticles has been implemented in the construction of sensors as modifiers. Attia and colleagues [ 61 ] constructed a sensor, modifying a carbon paste electrode (CPE) with nickel nanoparticles (Ni) and chloranil (CA). Chloranil is an electron acceptor reagent and was used as an electrocatalytic mediator and an electrode modifier.…”

“…Chloranil is an electron acceptor reagent and was used as an electrocatalytic mediator and an electrode modifier. The incorporation of Ni was reported to increase the active sites, thereby increasing the sensitivity towards escitalopram [ 61 ].…”