Electroanalytical Determination of Vancomycin at a Graphene‐modified Electrode: Comparison of Electrochemical Property between Graphene, Carbon Nanotube, and Carbon Black

Abstract

Carbon nanotube, graphene and carbon black, as electrode modifiers, were compared and evaluated for the electrochemical determination of vancomycin. Among them, the best results were obtained at the graphene‐modified electrode. Additions of vancomycin using square wave voltammetry at the graphene‐modified electrode showed a linear range from 0.70 μM to 50 μM and a detection limit of 0.20 μM was obtained. To control the correct dose of vancomycin and reduce its side effects, its accurate determination in blood plasma is very important. Therefore, the method was applied for the vancomycin determination in spiked human plasma samples and satisfactory recoveries were observed. The developed method exhibited fast analysis, high sensitivity, good repeatability and freedom from other interfering species.

Graphene–Gold Nanostructures Hybrid Composites Screen-Printed Electrode for the Sensitive Electrochemical Detection of Vancomycin

“…Also, graphene has special properties which make it an interesting working surface in electrochemistry. This direction was also supported by previously reported data [9], which showed that graphene is a more sensitive electrochemical platform for VAN detection and by other data present in the literature [10]. The further improvement of graphene as a sensing platform by modifying it with AuNSs was considered and tested.…”

“…In this regard, the direct electrochemical detection of VAN was recently reported [9,10]. Considering its large molecule and the need of analysis from complex matrices, a more complex approach for the direct electrochemical detection, involving the development and use of a complex electrochemical fingerprint of VAN, was recently reported [9].…”

“…For the direct electrochemical detection of VAN there is a need for new electrochemical platforms, with a higher sensitivity towards this molecule. This is because in the data reported in the literature [9,10], the combination of graphene and gold nanostructures (AuNSs) or gold nanoparticles (AuNPs) can represent a viable alternative due to the synergic electrocatalytic effect of graphene and AuNSs towards electrooxidation of VAN, but also due to the interaction between the AuNSs and VAN, which is usable in the cathodic domain [9,10].…”

Analytical methods for the determination of certain antibiotics used in critically ill patients

“…Electroanalytical determination of Vancomycin at a graphene-modified electrode using square wave voltammetry was developed for the determination of Vancomycin in human plasma [107] .…”

Highly Sensitive Electrochemical Sensor Based on Pt Doped NiO Nanoparticles/MWCNTs Nanocomposite Modified Electrode for Simultaneous Sensing of Piroxicam and Amlodipine

“…Modification of electrodes with various modifiers is very important for improving quality of sensors for drugs analysis with low sensitivity . In recent years, different types of nanomaterials such as metal oxide nanostructures have been applied as modifiers in sensors .…”