Electroanalytical sensors for antiretroviral drugs determination in pharmaceutical and biological samples: A review

Mokwebo, Kefilwe V.; Douman, Samantha F.; Uhuo, Onyinyechi V.; Januarie, Kaylin Cleo; Oranzie, Marlon; Iwuoha, Emmanuel I.

doi:10.1016/j.jelechem.2022.116621

Cited by 10 publications

(2 citation statements)

References 140 publications

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“…Electroanalytical methods have proven to be sensitive, affordable, and ecofriendly alternatives to provide accurate determinations of analytes in samples of variable complexity. For instance, these techniques have been applied to detect pharmaceuticals, vitamins, proteins, and biological molecules qualitatively and quantitatively with limits of detection reaching the nanomolar range. − …”

Section: Introductionmentioning

confidence: 99%

Electrifying Fruit Juice: Integrating Applied Electroanalytical Chemistry into the Undergraduate Curriculum

Lima,

Singh,

Bulleeraz

et al. 2024

J. Chem. Educ.

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Electroanalytical chemistry has been advanced through portable devices, providing methods and sensors for the detection of analytes with high sensitivity and accuracy. This subfield of electrochemistry has the potential to be utilized in industry and analytical quality control, in general. This results in an increasing demand for trained personnel, capable of operating benchtop and portable electroanalytical equipment. Although electrochemical techniques are routinely taught in theoretical undergraduate courses, they need to be more often incorporated into experimental didactic activities. Herein, we describe the application of an effective, hands-on, and low-maintenance experiment that can enhance the learning experience of electroanalytical methods and their use in industrial quality control settings. This activity is based on the detection of ascorbic acid (vitamin C) by employing cyclic voltammetry at unmodified glassy carbon electrodes (GCE) in real juice samples. This didactic experiment teaches students about the theoretical concepts of cyclic voltammetry, three-electrode cell setup, chemical reversibility, data treatment, and quantitative analysis. This teaching approach was conducted in a second-year analytical chemistry course and was easily adapted to social distancing measures imposed by the COVID-19 pandemic.

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Section: Introductionmentioning

confidence: 99%

Electrifying Fruit Juice: Integrating Applied Electroanalytical Chemistry into the Undergraduate Curriculum

Lima,

Singh,

Bulleeraz

et al. 2024

J. Chem. Educ.

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show abstract

“…One of the ARV that is extensively prescribed is efavirenz (EFV). Once consumed, this benzoxazine compound is poorly absorbed by the body (bioavailability of 45-50%) and takes 5 hr to reach its peak plasma concentration (C max ) of 13 µmol L − 1 [3][4][5]. The drug is further metabolised by cytochrome P450 2B6 (CYP2B6) enzymes into several hydroxy-efavirenz, with S-8-hydroxyefavirenz being the primary metabolite excreted [6].…”

Section: Introductionmentioning

confidence: 99%

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Mokwebo

Murphy

Guin

et al. 2023

Preprint

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A collection of the best practice examples of electroanalytical applications in education: from polarography to sensors

Cetinkaya,

Kaya,

Ozkan

2023

J Solid State Electrochem

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Electroanalytical sensors for antiretroviral drugs determination in pharmaceutical and biological samples: A review

Cited by 10 publications

References 140 publications

Electrifying Fruit Juice: Integrating Applied Electroanalytical Chemistry into the Undergraduate Curriculum

Electrifying Fruit Juice: Integrating Applied Electroanalytical Chemistry into the Undergraduate Curriculum

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

A collection of the best practice examples of electroanalytical applications in education: from polarography to sensors

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