Electrocardiographic abnormalities and dyslipidaemic syndrome in children with sickle cell anaemia

Adegoke, Samuel Ademola; Okeniyi, John A.O.; Akintunde, Adeseye A

doi:10.5830/cvja-2015-059

Cited by 17 publications

(28 citation statements)

References 20 publications

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“…In men, TG was related to ECG parameters except for QTc interval and S amplitude but in women, it had significant associations with heart rate, R amplitudes, Sokolow-Lyon index, QT interval, P and QRS axis. Although we did not find any correlation between TG and PR interval in women and a slight significant relationship in men but Adegoke et al, 39 reported that triglyceride had a positive correlation with the PR interval (r = 0.3). This difference may be due to their different population and age because they have studied children with sickle cell anemia.…”

Section: Each Metabolic Syndrome Component and Ecg Parameterscontrasting

confidence: 89%

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

Yazdanpanah¹,

Sayyadipoor²,

Hojati³

et al. 2020

DMSO

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Background: Metabolic syndrome (MetS) as a set of cardiac risk factors and its growing prevalence is one of the major concerns in different societies. In this study, we aimed to investigate the relationship between Mets and electrocardiogram (ECG) parameters and abnormalities as indicators for subclinical cardiovascular diseases (CVD). Methods: In this sub-analysis study, we used the data from Fasa PERSIAN Cohort Study which includes subjects age 35-70 years. Subjects with available ECG data included in the study (n=7002) and subjects with missing data on MetS components and non-sinus rhythm ECG were excluded (n=44). The MetS definition based on the Adult Treatment Panel (ATP) III guidelines and also a 12-lead ECG was obtained from all participants. Results: Our study population (n=6958) showed a mean age of 48.60±9.34 years and also 1656 (24.2%) subjects had MetS. Except for P duration, PR interval and S amplitude in men and P amplitude, S amplitude, Sokolow-Lyon Index, and QT interval in women, other ECG parameters differ significantly between subjects with and without Mets (P<0.05). Also among ECG abnormalities, prolonged P duration (≥120ms), QRS duration (≥100ms), and QTc interval (>450ms in male, >470ms in female) had a significant association with MetS in the total population. Waist circumferences (WC) showed the most count of significant relationship with ECG parameters in both genders. In males, WC more than ATP cut-points had significant associations with prolonged P and QRS duration, and also blood pressure (BP) had significant associations with prolonged P and QRS durations and QTc interval. In females, the MetS component except triglyceride had at least a significant relationship with prolonged P and/or QRS duration. Conclusion: MetS and its component especially WC and BP were associated with ECG parameters and abnormalities. These associations with ECG as a marker of subclinical CVD showed the importance of MetS and each component in our population to monitor in the further longitudinal studies.

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Section: Each Metabolic Syndrome Component and Ecg Parameterscontrasting

confidence: 89%

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

Yazdanpanah¹,

Sayyadipoor²,

Hojati³

et al. 2020

DMSO

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“…The PCV, haemogblogin concentration and red cell counts were significantly lower among sickle cell disease subjects, similar to findings by Adegoke, this could be due to the ongoing haemolysis, nutritional deficiencies, frequent crises and repeated infections they are exposed to [7]. This study also showed higher values of white blood cell and platelet in the cases compared with control.…”

Section: Pattern Of Laboratory Parameters In the Study Participantssupporting

confidence: 88%

Evaluation of Tp-e Interval and Tp-e/QTc Ratio among Patients with Steady State Sickle Cell Disease

Akinlade¹,

Akintunde²,

Olabode³

et al. 2019

WJCD

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Sickle cell disease (SCD) has been regarded as an inflammatory and procoagulatory disease with profound cardiovascular abnormalities including propensity for ventricular arrhythmogenesis. Tp-e and Tpe/QTc ratio however has been proposed as better indicators of arrythmogenesis and has been shown to be prolonged in many inflammatory conditions and correlate with levels of inflammatory markers. However, correlation between Tpe/QTc ratio and the level of highly sensitive C-reactive protein (hs-CRP) and plasminogen activator inhibitor (PAI) have not been reported in SCD. This study aims at evaluating Tp-e Interval and Tp-e/QTc ratio among steady state Sickle cell disease patients in relationship to the degree of anaemia, inflammatory and profibrotic markers. Methodology: A cross-sectional hospital-based study comprises 30 sickle cell anaemia patients in steady state with an equal number of controls having genotype HbAA and HbAS respectively. Clinical, laboratory and ECG parameters were obtained. Results: A total of 90 participants are with mean age 24.2 ± 5.6. The study showed that sickle cell disease patient had significantly lower level of PCV and higher level of PAI, platelet and total white cell count (p value < 0.05). C-reactive protein was also higher in them. 76.7% of HbSS patients had abnormal ECG. QTc and Tp-e were also prolonged in sickle cell disease patients compared with controls. An association was found between the level of PCV, PAI and prolonged Tp-e and QTc. Conclusion: Sickle cell disease patients have higher levels of inflammatory markers and abnormal ECG patterns are common in them. Moreover, the levels of these inflammatory markers correlate with Tp-e parameters.

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“…Eleven of these articles had two or more conditions. Comorbidities such as diabetes (37,76,77), hyperlipidemia (95,96), and thyroid dysfunction (97) may affect ECGs and obscure the true effect of hypertension on ECGs. Future studies comparing normotensive individuals to individuals with hypertension need comprehensive exclusion criteria to remove participants with comorbidities from the study population.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hypertension Using Clinical Electrocardiogram Features: A First-Ever Review

et al. 2020

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Hypertension affects an estimated 1.4 billion people and is a major cause of morbidity and mortality worldwide. Early diagnosis and intervention can potentially decrease cardiovascular events later in life. However, blood pressure (BP) measurements take time and require training for health care professionals. The measurements are also inconvenient for patients to access, numerous daily variables affect BP values, and only a few BP readings can be collected per session. This leads to an unmet need for an accurate, 24-h continuous, and portable BP measurement system. Electrocardiograms (ECGs) have been considered as an alternative way to measure BP and may meet this need. This review summarizes the literature published from January 1, 2010, to January 1, 2020, on the use of only ECG wave morphology to monitor BP or identify hypertension. From 35 articles analyzed (9 of those with no listed comorbidities and confounders), the P wave, QTc intervals and TpTe intervals may be promising for this purpose. Unfortunately, with the limited number of articles and the variety of participant populations, we are unable to make conclusions about the effectiveness of ECG-only BP monitoring. We provide 13 recommendations for future ECG-only BP monitoring studies and highlight the limited findings in pregnant and pediatric populations. With the advent of convenient and portable ECG signal recording in smart devices and wearables such as watches, understanding how to apply ECG-only findings to identify hypertension early is crucial to improving health outcomes worldwide.

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Electrocardiographic abnormalities and dyslipidaemic syndrome in children with sickle cell anaemia

Cited by 17 publications

References 20 publications

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

Evaluation of Tp-e Interval and Tp-e/QTc Ratio among Patients with Steady State Sickle Cell Disease

Assessment of Hypertension Using Clinical Electrocardiogram Features: A First-Ever Review

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