Electrocardiographic and hemato-biochemical effects of two balanced anesthetic protocols in dogs

Khurana, Anubhav; Kumar, Adarsh; Sharma, Sandeep; Kumar, Amit

doi:10.14202/vetworld.2014.835-841

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…No significant increase was recorded for duration of P-wave at different time intervals as compared to the respective preinduction values. Insignificantly increased P-wave duration observed in the present study in all the groups was also Khurana et al (2014) with butorphanoldiazeapam-propofol and butorphanol-acepromazinepropofol and Rafee et al (2016) with dexmedetomidineketamine with butorphanol or pentazocine. The slightly increased P-wave duration observed in the present study might be due to butorphanol lengthening the time for action potential and increasing the cardiac conduction time (Cardoso et al 2016).…”

Section: Resultssupporting

confidence: 71%

Cardiopulmonary Functions in Dogs under Propofol, Ketamine and Isoflurane Anaesthesia Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

Bayan¹,

Sarma²,

Rao³

et al. 2021

IJAR

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Background: The study was conducted to evaluate the cardiopulmonary functions in dog under propofol, ketamine and isoflurane anaesthesia premedicated with dexmedetomidine and butorphanol.Methods: Four groups of dogs (A,B,C and D) comprising of six animals in each groups were premedicated with glycopyrrolate @ 0.01 mg/kg, dexmedetomidine @5ìg/kg IV and Butorphanol @ 0.1mg/kg IV. Induction was done with propofol (A and B) and with ketamine (C and D). The anaesthesia was maintained with isoflurane (A and C), propofol (B) and ketamine (D). The cardiopulmonary functions were recorded at 0 minute (before premedication) and 20 minutes, 40 minutes and 60 minutes. Result: The heart rate decreased significantly in Group B while there was a significant gradual increase in heart rate in Group D. A significant decrease in respiratory rate was observed in all the groups with a lowest value in group D. The systolic pressure decreased significantly in Group A, B and C but in Group D, the systolic pressure decreased initially at 20 minute. The diastolic pressure decreased significantly in Group A and Group B and but in group D, the diastolic pressure decreased at 20 minute. A significant decrease in mean arterial pressure was recorded in Group A, B and C. In Group D, a decrease in the mean arterial pressure was noticed at 20 minute. The SpO2 level remained near the base line values with slight variation in Group A and C where as the values remained at lower level from the base line value in Group B and D. The EtCO2 level showed non-significant changes in Group A and C. In Group B and D, the EtCO2 levels increased non-significantly with the highest value recorded in Group D. The ECG parameters remained within the normal limit with slight variation according to the heart rate.

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Section: Resultssupporting

confidence: 71%

Cardiopulmonary Functions in Dogs under Propofol, Ketamine and Isoflurane Anaesthesia Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

Bayan¹,

Sarma²,

Rao³

et al. 2021

IJAR

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“…Furthermore, only 8% of dogs were reclassified to a higher American Society of Anesthesiologists (ASA) risk score rating (Alef et al 2008). In addition, haematological and biochemical changes in dogs under anaesthesia are well established (Alkattan & Helal 2013;Khurana et al 2014;Wilson et al 2004). One of the aims of the study was to determine these changes as the colloids were infused.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Blood acid–base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs

Buck

Bester

Boustead

et al. 2020

Journal of the South African Veterinary Association

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Synthetic colloids are commonly administered to dogs to treat absolute or relative hypovolaemia. Voluven® (tetrastarch 130/0.4) and Gelofusine® (succinylated gelatin) are available to veterinarians in South Africa. In humans, use of these products has caused acid–base derangements, changes in haematology and impaired haemostasis. We aimed to investigate these effects in healthy normovolaemic dogs. Eight healthy adult beagle dogs underwent a cross-over study, receiving Voluven® or Gelofusine® (10 mL/kg/h for 120 min) once each with a 14-day washout between treatments. Dogs were premedicated with dexmedetomidine (10 µg/kg intramuscularly). Anaesthesia was induced with propofol and the dogs were maintained with isoflurane-in-oxygen. The anaesthetised dogs were connected to a multi-parameter monitor to monitor physiological parameters throughout. Catheters placed in a jugular vein and dorsal metatarsal artery allowed sampling of venous and arterial blood. Blood was collected immediately prior to commencement of colloid infusion, after 60 min infusion and at the end of infusion (120 min) to allow for arterial blood gas analysis, haematology and coagulation testing (activated partial thromboplastin time [aPTT], prothrombin time [PT] and thromboelastography [TEG]). There was no effect, between treatments or over time, on blood pH. The haemoglobin concentration, erythrocyte count and haematocrit decreased significantly over time (all p 0.01), with no differences between treatments, and remained within normal clinical ranges. There were no differences between treatments or over time for the TEG, aPTT and PT tests of haemostasis. At the dose studied, Voluven® and Gelofusine® had comparably negligible effects on blood acid–base balance and coagulation in normovolaemic dogs.

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“…Historically, poor attention has been paid by veterinary cardiologists to an important component of ventricular repolarisation, namely the ST segment, whose interpretation is currently performed almost empirically in small animal practice. This knowledge gap can have relevant clinical consequences, as it may not allow for the early identification of ventricular repolarisation abnormalities expressed in the form of ST segment changes that may arise from myocardial injury due to cardiac (Tilley 1992b, Davainis et al 2004, Sleeper et al 2015, Santilli et al 2018b, Lekane et al 2020) and extracardiac diseases (Tilley 1992b, Dvir et al 2004, Surachetpong et al 2016, Santilli et al 2018b, Pugliese et al 2020, the administration of drugs and medium contrast agents (Tilley 1992b, Khurana et al 2014, Santilli et al 2018b, Tamogi et al 2020) and electrolyte abnormalities (Tilley 1992b, Santilli et al 2018b.…”

Section: Introductionmentioning

confidence: 99%

“… 2020 ), the administration of drugs and medium contrast agents (Tilley 1992b , Khurana et al . 2014 , Santilli et al . 2018b , Tamogi et al .…”

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of the ST segment electrocardiographic features in 180 healthy dogs

Romito

Castagna²,

Pelle

et al. 2022

J of Small Animal Practice

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Normal features of the ST segment are poorly characterised in dogs. This study aimed to describe ST segment characteristics in a population of healthy dogs.Materials and MethOds: Medical records were reviewed to identify healthy dogs that underwent an electrocardiogram. Several ST segment qualitative parameters were evaluated: presence/absence of deviation, type of deviation (depression/elevation) and morphological patterns of depression (horizontal, downsloping, upsloping and sagging) and elevation (horizontal, concave and convex). Moreover, the amplitude of ST segment depression/elevation was measured. The potential effect of sex, bodyweight, age and somatotype on the presence/absence of ST segment deviation was evaluated through binary logistic regression.results: One hundred and eighty dogs were enrolled. The deviation was evident in 43 of 180 dogs (23.9%), among which 36 showed depression and seven showed elevation. The median depression amplitude was 0.1 (range 0.05 to 0.3) mV. The mean elevation amplitude was 0.136 ±0.055 mV. Concerning depression morphology, the horizontal pattern was overrepresented, followed by the downsloping and upsloping ones.Concerning elevation morphology, all dogs showed a concave pattern. No meaningful effect of sex, bodyweight, age and somatotype on the presence/absence of ST segment deviation was documented. clinical significance: Normal features of canine ST segment were described and made available for clinical use.

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Electrocardiographic and hemato-biochemical effects of two balanced anesthetic protocols in dogs

Cited by 6 publications

References 12 publications

Cardiopulmonary Functions in Dogs under Propofol, Ketamine and Isoflurane Anaesthesia Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

Cardiopulmonary Functions in Dogs under Propofol, Ketamine and Isoflurane Anaesthesia Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

Blood acid–base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs

Retrospective evaluation of the ST segment electrocardiographic features in 180 healthy dogs

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