Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration

Reich, Marsha R.; Ohad, Dan G.; Overall, Karen L.; Dunham, Arthur E.

doi:10.2460/javma.2000.216.1571

Cited by 34 publications

(13 citation statements)

References 13 publications

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“…Amitriptyline should be used cautiously in dogs with conduction abnormalities as it may cause ECG changes and, at higher doses, ventricular arrhythmias (Reich et al . ). It should not be used with tramadol, St. John's wort and other drugs that act via serotonin and norepinephrine reuptake, as they may have interactions that lead to serotonin syndrome (Ener et al .…”

Section: Therapies In Chronic Painmentioning

confidence: 97%

“…There are no controlled trials of their use in dogs but amitriptyline has been reported to be beneficial in a case series of three dogs with neuropathic pain (Cashmore et al 2009). Amitriptyline should be used cautiously in dogs with conduction abnormalities as it may cause ECG changes and, at higher doses, ventricular arrhythmias (Reich et al 2000). It should not be used with tramadol, St. John's wort and other drugs that act via serotonin and norepinephrine reuptake, as they may have interactions that lead to serotonin syndrome (Ener et al 2003).…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

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Therapeutic options for the treatment of chronic pain in dogs

MacFarlane

Tute

Alderson

2014

J of Small Animal Practice

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Chronic pain is a widely recognised problem in humans and is being increasingly recognised as a significant problem in dogs. Whilst a large number of therapies are described and utilised to treat chronic pain in dogs, there is a severe shortage of evidence to guide practitioners in selection of treatments. Until more evidence becomes available, practitioners should adopt a cautious approach, utilising licensed treatments first when possible. Non‐pharmacological therapies should be incorporated into the chronic pain management plan whenever possible. Given the probable prevalence of chronic pain in dogs there is an urgent need for research to identify effective treatments.

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Section: Therapies In Chronic Painmentioning

confidence: 97%

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Therapeutic options for the treatment of chronic pain in dogs

MacFarlane

Tute

Alderson

2014

J of Small Animal Practice

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“…Συνήθως, επιλέγεται η χλωμιπραμίνη, επειδή παρουσιάζει τις μικρότερες παρενέργειες, σε αρχική δόση 1 mg/kg σ.β. per os, κάθε 12 ώρες, η οποία μπορεί να διπλασιαστεί ή τριπλασιαστεί, εφόσον δεν υπάρχει ικανοποιητικό αποτέλεσμα εντός 2 έως 4 εβδο μάδων (Hewson et al 1998, MacDonald and Bradley 2000, Reich et al 2000, Landsberg 2001, Seksel and Lindeman 2001, Virga 2003, Crowell-Davis 2006, Tapp and Virga 2012. Οι εκλεκτικοί αναστολείς επαναπρόσληψης της σεροτονίνης, που έχουν επίσης Πίνακας 4.…”

Section: θεραπευτικη αντιμετωπισηunclassified

To σύνδρομο της δερματίτιδας από λείξη των άκρων στο σκύλο

Giannoulopoulos

Saridomichelakis

2017

J Hellenic Vet Med Soc

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Canine acrai lick dermatitis is a complicated and challenging syndrome occurring in companion animal dermatology. Skin lesions are caused by intense and prolonged licking of a localized area, usually on the lower parts of the limbs that progressively may result in plaque or nodule formation with alopecia, erythema, hyperpigmentation, exudation,erosion and ulceration. Aerai lick dermatitis develops more often in male dogs of large breeds and has a multifactorial aetiology. The underlying causes may be broadly separated into organic (e.g., pruritic skin diseases, painful conditions) and psychogenic. The former subset includes mainly deep bacterial pyoderma, atopic dermatitis, food allergy, foreign bodies, sensory neuropathies and painful bone and articular diseases. The psychogenic subset may be either a primary (e.g., the result of long-standing anxiety, boredom, attention-seeking or stereotypic behavior) or a psychosomatic behavioural abnormality.Regardless of the aetiology and the primary role it may play, the most common complication in the psychogenic aerai lick dermatitis is actually the deep bacterial pyoderma observed in the majority of the cases. Diagnosis of the disorder is reached after exclusion of similar-looking skin diseases, such as ringworm kerion, demodicosis, leishmaniosis, sterile granulomas and neoplasia. An extensive list of diagnostic tests is necessary to identify the underlying cause(s) and includes cytological examination, bacterial culture and antibiotic susceptibility testing, histopathological examination, imaging of the affected area and hypoallergenic food trial. A prerequisite to diagnosing the psychogenic subset of the disease is to rule-out potential organic causes, coupled with persistence of skin licking, despite resolution of deep bacterial pyoderma.Regardless of the underlying cause, therapy should always include mechanical restrain, as well as the long-term topical and systemic use of antimicrobials that ideally should be selected based on the results of antimicrobial susceptibility testing. Specific treatment in also warranted to resolve potential organic causes of the syndrome, whereas, management of its psychogenic subset should be based on avoidance of the causative and triggering factors, desensitization and counter conditioning, along with the administration of psychotropic medication. Alternative therapeutic modalities, considered supplementary or employed when everything else fails, may include topical glucocorticoids, dimethyl sulfoxide, capsaicin or tacrolimus, as well as cryosurgery, laser surgery, acupuncture or radiation therapy.

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“…Conversely, the owner reported a worsening of aggression during walks. Clomipramine was selected because it has been approved for use in dogs, has been used to treat aggression in many species, [21][22][23] and has mild sedative effects 18 that were desirable for keeping the dog calm during counter-conditioning exercises during walks. The dog' s arousal level during walks appeared to be hindering the owner' s counterconditioning attempts, despite an appropriate dosage of paroxetine.…”

Section: Treatmentmentioning

confidence: 99%

Animal Behavior Case of the Month

Herron¹

2010

javma

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Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration

Cited by 34 publications

References 13 publications

Therapeutic options for the treatment of chronic pain in dogs

Therapeutic options for the treatment of chronic pain in dogs

To σύνδρομο της δερματίτιδας από λείξη των άκρων στο σκύλο

Animal Behavior Case of the Month

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