Electrocardiographic Characteristics in Patients With Pulmonary Sarcoidosis Indicating Cardiac Involvement

Schuller, Joseph L.; Olson, Matthew D.; Zipse, Matthew M.; Schneider, Preston M; Aleong, Ryan G.; Wienberger, Howard D.; Varosy, Paul D.; Sauer, William H.

doi:10.1111/j.1540-8167.2011.02099.x

Cited by 96 publications

(59 citation statements)

References 20 publications

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“…Fragmented QRS on ECG has been found a marker of myocardial scarring or fibrosis in various diseases [8,21,22]. It can serve as an inexpensive and readily available electrocardiographic index of myocardial fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of fQRS was found to be 9.2% among healthy LV -left ventricular; LVEDD -left ventricular end diastolic diameter; LVESD -left ventricular end systolic diameter; IVS -interventricular septum; PW -posterior wall; LA max volume -left atrium maximum volume; E -mitral inflow peak early diastolic wave velocity; Amitral inflow peak late diastolic wave velocity E' -flow velocity of the early diastole using tissue Doppler echocardiography; A' -flow velocity of the late diastole using tissue Doppler echocardiography; Sa -peak velocity of myocardial systolic wave; IVV -isovolumic velocity; IVA -isovolumic acceleration; MPI -myocardial performance index www.cardiologyjournal.org middle-aged Finnish subjects [23]. The prevalence is increased in various diseases, including ST elevation myocardial infarction (21.9%) [7], cardiac sarcoidosis (75%) [21], and chronic kidney disease (60%) [22]. These data suggest that fQRS prevalence increases with myocardial involvement.…”

Section: Discussionmentioning

confidence: 99%

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Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

Oner

Ertürk²,

Birant³

et al. 2015

Cardiol J.

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041). MetS was associated with subclinical LV systolic and LV diastolic dysfunctions. In subgroup analyses of MetS patients, the presence of fQRS on ECG had a higher E/E' ratio and lower E' velocity, indicating pronounced diastolic dysfunction, as well as lower isovolumic acceleration (IVA), indicating profound subclinical LV systolic dysfunction. E/E' ratio and IVA were independent predictors of fQRS presence in patients with MetS. Conclusions: Fragmented QRS is more common among MetS patients compared to non--MetS patients. The presence of fQRS is associated with pronounced subclinical LV systolic and diastolic dysfunctions in MetS patients. (Cardiol J 2015; 22, 6: 691-698)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

Oner

Ertürk²,

Birant³

et al. 2015

Cardiol J.

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“…Other reasons for ECG abnormalities has to be excluded [9]. Study performed in Japan on 227 patients with pulmonary sarcoidosis proved that electrocardiographic abnormalities such as: increased heart rate, prolonged PR interval, RBBB and ST-T abnormalities were associated with increased risk of cardiac events defined as: occurrence of advanced AV block, VT and systolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic abnormalities in patients with pulmonary sarcoidosis (RCD code: III)

Błaut-Jurkowska¹,

Kaźnica-Wiatr

Żygadło

et al. 2017

Journal of Rare Cardiovascular Diseases

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Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas. Etiology of the disease remains unknown. From 3.7% to 54.9% patients with extra-cardiac sarcoidosis have asymptomatic heart involvement. Conduction abnormalities, arrhythmias and congestive heart failure are the most common clinical manifestations of cardiac sarcoidosis (CS). The aim of the study was to evaluate the type and frequency of electrocardiographic abnormalities in patients with pulmonary sarcoidosis and to compare differences in the occurrence of electrocardiographic changes between patients diagnosed with CS and patients without confirmation of CS. Materials and methods: 49 patients (18 women, 31 men), mean age 45.6 ±12.2 years with biopsy-proven pulmonary sarcoidosis were enrolled in the study. The patients were divided into two groups. Group 1 consisted of 12 patients diagnosed with CS, and Group 2 of 37 patients without diagnosis of CS. 12-lead baseline electrocardiogram (ECG) was recorded for all participants. Results: 89.8% patients with pulmonary sarcoidosis had abnormal ECG. The most common ECG abnormalities were ST-T changes observed in 79.6%. Conduction abnormalities were present in 26.5% of patients. 22.45% patients had left axis deviation. Rhythm abnormalities were recorded in 20.4% of all analyzed ECGs. ECGs of 8.16% of patients met criteria of hypertrophy. There was a trend towards more frequent prevalence of some ECG changes in patients with CS than patients without CS. However, these differences were not statistically significant. Conclusions: We observed a trend towards more frequent prevalence of some ECG abnormalities in a group of patients with CS than in patients without CS. However, these differences were not statistically significant. ECG abnormalities in patients with pulmonary sarcoidosis require further diagnostics. JRCD 2017; 3 (3): 81-85

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“…El algoritmo (figura 3) incluye la historia médica inicial con énfasis en los síntomas de falla cardíaca y los trastornos del ritmo; examen físi-co cardíaco completo y un electrocardiograma de 12 derivaciones. Este último tiene alta sensibilidad, pero baja especificidad, con valor predictivo positivo de 0,68 y valor predictivo negativo de 0,88; los hallazgos más frecuentes son la fragmentación del QRS (fQRS) en dos derivaciones contiguas o el bloqueo de rama, ya sea derecho o izquierdo, especialmente si hay historia de compromiso extracardíaco (18).…”

Section: Diagnóstico Clínico Por Medio De Estudios Invasivos Y No Invunclassified

Cardiomiopatías infiltrativas. Presentación de un caso de sarcoidosis cardíaca

Muñoz-Ortiz

Arévalo-Guerrero

Abad³

et al. 2017

iatreia

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RESUMENLa sarcoidosis se caracteriza por la presencia de granulomas no caseificantes y puede afectar cualquier órgano. En el corazón se manifiesta como cardiomiopatía infiltrativa. La frecuencia del compromiso cardíaco es alrededor del 30 %, pero solo el 5 % son sintomáticos. Presentamos el caso de una paciente con sarcoidosis sistémica, diagnosticada por biopsia de un ganglio mediastinal y tratada inicialmente con esteroides. Posteriormente tuvo compromiso del corazón, que se manifestó por falla cardíaca y edema pulmonar. El diagnóstico se hizo por ecocardiografía y resonancia magnética cardíaca. Respondió favorablemente al tratamiento con esteroides y ciclofosfamida. PALABRAS CLAVECardiomiopatía; Inmunosupresores; Sarcoidosis SUMMARY Infiltrative cardiomyopathies. Report of a case of cardiac sarcoidosisSarcoidosis is characterized by the presence of non-caseating granulomas that may affect any organ. Heart involvement manifests as cardiomyopathy. Frequency of cardiac involvement in sarcoidosis is around 30 %, but only 5 % of such cases are symptomatic. We report the case of a patient with systemic sarcoidosis diagnosed by means of biopsy of a mediastinal lymph node. Initial treatment was with steroids. She later had cardiac involvement manifested by heart failure and pulmonary edema. Diagnosis was established by echocardiography and cardiac magnetic resonance. Response to treatment with steroids and cyclophosphamide was favorable.

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Electrocardiographic Characteristics in Patients With Pulmonary Sarcoidosis Indicating Cardiac Involvement

Abstract: The presence of fQRS or BBB pattern in patients with pulmonary sarcoidosis is associated with cardiac involvement and therefore should prompt further evaluation.

Cited by 96 publications

References 20 publications

Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

Electrocardiographic abnormalities in patients with pulmonary sarcoidosis (RCD code: III)

Cardiomiopatías infiltrativas. Presentación de un caso de sarcoidosis cardíaca

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