Electrocardiographic events and cholesterol reduction with pravastatin in patients with hypercholesterolemia: the Hokuriku Lipid Coronary Heart Disease Study-Pravastatin Atherosclerosis Trial

Shimizu, Masami; Koizumi, Junji; Miyamoto, Susumu; Origasa, Hideki; Mabuchi, Hiroshi

doi:10.1016/j.ijcard.2004.02.006

Cited by 3 publications

(1 citation statement)

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“…According to our findings, plasma lipids and smoking habit were not associated with a higher risk score. As for lipids, most of the subjects with hypercholesterolemia were treated with statins, which could reduce the incidence of ischemic ECG changes regardless of lipid concentrations, as shown in previous studies [11]. Furthermore, LDL-C mainly predicts ECG signs of previous myocardial infarction [12], which is just one of the five ECG alterations included in the Finnish Score.…”

Section: Discussionmentioning

confidence: 79%

Laboratory and Instrumental Risk Factors Associated with a Sudden Cardiac Death Prone ECG Pattern in the General Population: Data from the Brisighella Heart Study

Coppola

Cicero

Fogacci

et al. 2021

JCM

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Sudden cardiac death (SCD) remains a daunting problem and a major public health issue. We applied the validated Electrocardiogram (ECG) score to the Brisighella Heart Study (BHS) cohort, in order to verify if there were also other recognized laboratory and instrumental risk factors for cardiovascular disease associated with a sudden death risk-prone pattern. We examined the ECG traces of 1377 participants of the 2016 BHS survey and identified 33 subjects at high risk for SCD (while 1344 subjects had no cumulative ECG abnormalities). Serum uric acid (SUA) and carotid-femoral pulse wave velocity (cfPWV) values were significantly higher in the high-risk cohort (p < 0.05) and were both independently associated with the presence of ECG abnormalities [Odd ratio (OR) = 2.14, p < 0.05–OR = 1.23, p < 0.05, respectively]. A similar independent correlation was found with long-term non-steroid anti-inflammatory drugs (NSAIDs) use, more widespread among high-risk subjects (OR = 1.19, p < 0.05). Conversely, the analysis did not show any significant association with impaired renal function (p = 0.09). This study showed that long-term NSAID use and high SUA and cfPWV values are independent risk factors for ECG abnormalities predictive of SCD. These findings herald the need for further prospective research to identify the optimal combination of SCD risk markers in order to prevent fatal events.

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Section: Discussionmentioning

confidence: 79%