Electro cardiogram is a good tools for monitoring the physiological status of animals and human during anesthesia. This investigation was directed to record the physiological and electrocardiographic findings of anesthetized one humped camels by different doses of ketamine and medetomidine. Twenty clinically apparently healthy male one humped camels ageing 3-4 years weighting 280-300 Kg were allocated into four groups (five animal of each), group (I) control un anesthetized camels and groups (II,III) , receiving Ketamine only by I/V route at dose of 1mg/Kg and 2mg/kg body weight respectively. While, group (IV) was injected with Medetomidine in a dose of 30 µgm /kg followed by 1 mg /kg of ketamine. Core body temperature (BT), respiratory rate (RR), heart rate (HR) and electrocardiogram were determined to represent physiological and clinical finding..The ECG results reveled that, in group II there were tachycardia as shown in lead I, II and III one minute post ketamine injection. After 5 min., decreased P-R interval and QRS complex time while T wave strength was increased specially in lead II. All these findings were persisted after 10 min. in addition to increase the negativity of S waves and strength of P wave's .while after 15 min., P waves was equal to T waves in amplitude with still increased heart rates. In group III; ketamine injection showed initial bradycardia with irregular rhythm with absent or decreased strength of T waves. After 5 and up to 10 min, showed tachycardia with S-T segment increased in time and QRS complex in its strength .After 15 min., there were irregular heart rate and inverted T waves in lead I, these findings were persisted until the end of experiment. Furthermore, the results revealed that, heart rate (HR) showed a tachycardia in group II and III that started with the beginning of the study and persisted for 30 min. while in group IV, medetomidine injection significantly lower the heart rate inducing bradycardia. Respiratory rate showed significant increases in all anesthetized groups starting from the beginning of experiment and was persisted at high rate for 30 min. before returning to control rate at the end of the study (at 45 min). Moreover, results appeared significant decreases in core body temperature in all anesthetized groups proceeded parallel to the time of experiment. It could