Electrocardiographic T-wave morphology and risk of mortality

Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial

“…Additionally, there was no effect of hydroxychloroquine on the MCS (slope estimate ΔΔMCS = 6.30 × 10 −5 , P = .34). As a reference, in a large primary care population (over 200 000 subjects), an increased MCS of 0.10 was associated with an increased mortality (adjusted hazard ratio for men: 1.61) 45 . In our study, healthy subjects received a total dose of 2400 mg hydroxychloroquine, with a maximum plasma concentration exceeding 200 ng/mL.…”

“…As a reference, in a large primary care population (over 200.000 subjects), an increased MCS of 0.10 was associated with an increased mortality (adjusted hazard ratio for men: 1.61). 46 In our study, healthy subjects received a total dose of 2400 mg hydroxychloroquine, with a maximum plasma concentration exceeding 200 ng/mL. The half-maximum inhibitory concentration (IC50) of hydroxychloroquine for hERG-channel inhibition is estimated between 2.5 and 8.4 µM.…”

Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

“…The QT interval is an important feature in the ECG because the interval is related to sudden death 33 . It is well known that abnormal T waves are difficult to measure correctly, which is important because these abnormal T waves are associated with increased mortality 34 . As seen in the supplementary (Supplementary Table S1 ), the network accurately measured even the most flattened T waves only marginally worse than the “easy-to-measure” peaked T waves with a sharp, well-defined end.…”

Celebrities in the heart, strangers in the pancreatic beta cell: Voltage‐gated potassium channels Kv7.1 and Kv11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes

“…This score has been shown to have independent prognostic information on mortality independently of heart rate and QT interval duration. 156 The T‐wave morphology change during the OGTT was more pronounced in patients with LQTS than healthy controls, indicating larger changes in ventricular repolarization during the OGTT in the individuals with LQTS. This, along with the increased QT interval, may pose an increased risk of cardiac arrhythmia.…”

“…In these studies, T‐wave morphology was evaluated with a morphology combination score which evaluates the shape of the T wave by looking at T‐wave flatness, T‐wave asymmetry and the appearance of a notch or hump on the T wave (notching). This score has been shown to have independent prognostic information on mortality independently of heart rate and QT interval duration 156 . The T‐wave morphology change during the OGTT was more pronounced in patients with LQTS than healthy controls, indicating larger changes in ventricular repolarization during the OGTT in the individuals with LQTS.…”