Electrocatalytic Alfuzosin Oxidation on Electrochemically Oxidized Glassy Carbon Modified with Multiwalled Carbon Nanotubes and Nickel Oxide Nanoparticles

Abstract

In the present research, a glassy carbon electrode (GCE) was activated aided by an electrochemical process in a 0.5 molar sodium hydroxide solution and then modified by nickel oxide (NiO) nanoparticles and multiwall carbon nanotubes (MWCNT) to obtain NiO/MWCNT/OGCE electrode. This electrode was morphologically and structurally characterized by scanning electron microscopy and electrochemical impedance spectroscopy. Cyclic voltammetric and chronoamperometry methods were employed to investigate the catalytic properties of the modified electrodes for Alfu electro-oxidation in buffer solution. The modified electrode exhibited promising electrocatalytic properties toward the oxidation of Alfuzosin (Alfu).The electrocatalytic role of NiO in Alfu electro-oxidation process was clearly demonstrated in comparison to the OGCE/MWCNT electrode. The reason behind this electrocatalytic activity relays on a synergistic effect involving both NiO and MWCNT. Differential pulse voltammetry (DPV) was employed as a sensitive procedure for the quantitative determination of Alfu. It was found that the oxidation current is in direct relationship with the concentration of Alfu in the 0.01-2.0μM and 2.0-90μM concentration ranges, with 0.0006 μM detection limits. Moreover, no significant response was observed in the presence of the common interference, demonstrating the good selectivity of Alfu. The method was successfully used for the determination of Alfu content in real samples.

Electrochemical detection of chlorpheniramine maleate in the presence of an anionic surfactant and its analytical applications

“…The detection limits reported at different electrochemical methods for CPM is tabulated in the Table 1. This method was better as compared to other reported similar methods [17][18][19][20][21][22][23].…”

“…As these methods are rather sophisticated, expensive, time consuming methods. Few attempts have also been made to use electroanalytical technique for the determination of CPM using carbon paste electrodes [17][18][19], modified glassy carbon electrode [20][21][22] and hanging mercury drop electrode [23]. However these methods have attracted much attention of researchers towards to their sensitivity for the determination of organic molecules, rapidity of analysis, inexpensive instrumentation and no complex sample pretreatment are also considered as eco-friendly [24,25].…”

Development of Green Differential Pulse Voltammetric Strategy for the Determination of Alfuzosin Hydrochloride at Pencil Graphite and Modified Carbon Paste Electrodes

“…This value referred to the participation of two electrons and protons in the electro-oxidation reaction of ALF which coincided with previously published results. 20,21…”

“…Different electrochemical techniques were also established for potentiometric, 16 conductometric, 17 and voltammetric analysis of ALF by linear sweep and normal pulse polarography, 18 Coulometric fast Fourier transform linear sweep voltammetry, 19 and differential pulse 20,21 and square-wave voltammetry. 22 To our knowledge from the literature review, few analytical studies were performed to investigate the elec-Metias et al: Development of Green Differential Pulse Voltammetric ... trochemical behavior of ALF, as depicted in Figure 1.…”

Two‐layered Au@Ag Bimetallic Nanocomposites‐poly (L‐Met) Platform for Highly Sensitive Chlorpheniramine Maleate Detection

“…(S)-γ-(4-Chlorophenyl)-N, N-dimethyl-2-pyridinepropanamine maleate, also known as chlorphenamine maleate (CPM), is an antihistamine used to treat the symptoms of allergic situations such as allergic rhinitis called hay fever, rhinitis, urticaria, and asthma [1][2]. It has also been used in veterinary applications.…”