Electrochemical behavior of atenolol, carvedilol and propranolol on copper-oxide nanoparticles

Shadjou, Nasrin; Hasanzadeh, Mohammad; Saghatforoush, Lotfali; Mehdizadeh, Robab; Jouyban, Abolghasem

doi:10.1016/j.electacta.2011.09.055

Cited by 55 publications

(23 citation statements)

References 25 publications

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“…The main aim of the current study is to examine voltammetric behavior of ATN especially with the use of NGCE/MWCNT, and then develop an electrochemical procedure for the sensitive, simple, and eco-friendly alternative to chromatography methods. Survey of literature revealed that no electroanalytical methods for determination of atenolol by using Nafion and multi-walled carbon nanotube coated glassy carbon electrode was reported Since, it has been done very few studies [21][22][23] on this topic according to our literature review, the voltammetric determination of ATN is the focus of this study. In order that make a significant contribution to the literature in this field, cyclic (CV) and differential pulse (DP) voltammetric study was planned.…”

Section: Atenolol (Atn) [4-[2-hydroxy-3-isopropylaminopropoxy]mentioning

confidence: 99%

The Ultra-sensitive method development using Nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

Kazıcı¹

2018

Pamukkale J Eng Sci

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ÖzAtenolol (Scheme 1) is antihypertensive drug that form β-blocker group, which widely used in the treatment of hypertension In this study, the redox properties of the Tensinor drug used in blood pressure treatment were examined on modified glassy carbon electrode and the electrodes prepared by coating carbon nanotubes on this modified electrode. In order to investigate the effects of nafion coated multi-walled glass nanotube (MWCNT / NGCE) electrode response and nafion coated glassy carbon electrode (NGCE) and electrode responses of only glassy carbon electrode (GCE) surfaces on the support electrolyte, pH and scan rate, the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used. Atenolol (ATN) was observed in the Britton-Robinson (BR) buffer solution (pH 7.0) thereabouts 1.11 V (vsAg / AgCl (3.0 mol L-1 KCl). Voltammetric method reacted linear at a concentration range between 3x10-5 μM and 9x10-2 μM under optimum analytical experimental conditions. The results of Tensinor's limit of detection on the Britton-Robinson (BR) (pH=7) buffer were found to be 7.67 x 10-5 mM and 2.5 x 10-4 mM, respectively. Additionally, in the study, interference effects experiments were performed with auxiliary substances used in the preparation of medicines and no negative effect was observed. Atenolol (Şekil 1), hipertansiyon tedavisinde yaygın olarak kullanılan βbloker grubunu oluşturan antihipertansif ilaçtır. Bu çalışmada; Tansiyon tedavisinde kullanılan Tensinör ilacının redoks özellikleri, modifiye camsı karbon elektrot ve bu modifiye elektrot üzerine karbon nano tüp kaplanarak hazırlanmış elektrotlarda incelenmiştir. Nafion kaplı çok duvarlı karbon nanotüp (MWCNT/NGCE) elektrot yanıtı ile Nafion kaplı camsı karbon elektrot (NGCE) ve sadece camsı karbon elektrot (GCE) yüzeylerinin elektrot yanıtlarının destek elektroliti, pH, ve tarama hızı üzerine etkilerini araştırmak için Çevrimsel voltametri (CV) ve Diferansiyel puls voltametri (DPV) yöntemleri kullanılmıştır.Atenolol (ATN) Britton-Robinson (BR) tampon çözeltisinde (pH 7.0) 1.11 V (vsAg/AgCl (3.0 mol L-1 KC1) civarında gözlenmiştir. Voltametrik yöntem, optimum analitik deney koşulları altında, 3x10-5 µM -9x10-2 mM konsantrasyon aralığında lineer tepki göstermiştir. Britton-Robinson (BR) (pH=7) tamponundaki Tensinör belirme sınırı sonuçları, sırasıyla 7.67 x 10-5 mM ve 2.5x10-4 mM olarak bulunmuştur. Ayrıca çalışmada ilaçların hazırlanmasında kullanılan yardımcı maddeler ile girişim etkisi deneyleri gerçekleştirilmiş ve olumsuz bir etkiye rastlanmamıştır.

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Section: Atenolol (Atn) [4-[2-hydroxy-3-isopropylaminopropoxy]mentioning

confidence: 99%

The Ultra-sensitive method development using Nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

Kazıcı¹

2018

Pamukkale J Eng Sci

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“…At this point, the analytical sciences play a key role, and among analytical techniques, electrochemical techniques are noteworthy [1]. This statement is justified due to some of its advantageous features, such as high sensitivity and selectivity, moderate cost, portability, rapid responses, possibility of system miniaturization, and analysis of complex matrices [2,3]. Nevertheless, the utilization of electrodes in their original form without adding any other component limits its use for sensitivity, stability, and many other reasons.…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemical techniques stand out because (1) they allow investigating the redox properties of the studied drug; (2) have rapid, sensitive, and selective responses; (3) render system miniaturization possible; and (4) permit analysis of complex matrices [2]. However, it must be pointed out that the use of MIP integrated on electrochemical devices for larger molecules, such as the carvedilol, is not so straightforward, because such molecules can hinder the creation of selective binding sites in the MIP.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, many analytical techniques have been employed for determination of CAR, such as high-performance liquid chromatography [28], spectrophotometry [29], capillary electrophoresis [30], and electrochemistry [2]. Electrochemical techniques stand out because (1) they allow investigating the redox properties of the studied drug; (2) have rapid, sensitive, and selective responses; (3) render system miniaturization possible; and (4) permit analysis of complex matrices [2].…”

Section: Introductionmentioning

confidence: 99%

“…As cardiovascular diseases are a major group of diseases, considering the frequency at which they occur and the number of deaths related to them, the quantitative determination of CAR in pharmaceuticals and in human plasma is important, mainly for quality control, as more and more people need medication to control these cardiovascular diseases [2,27].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development and Application of Electrochemical Sensor Based on Molecularly Imprinted Polymer and Carbon Nanotubes for the Determination of Carvedilol

et al. 2016

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This work describes the preparation of a glassy carbon electrode (GCE) modified with molecularly imprinted polymer (MIP) and multiwalled carbon nanotubes (MWCNTs) for determination of carvedilol (CAR). Electrochemical behavior of CAR on the modified electrode was evaluated using cyclic voltammetry. The best composition was found to be 65% (m/m) of MIP. Under optimized conditions (pH 8.5 in 0.25 mol·L −1 Britton-Robinson buffer and 0.1 mol·L −1 KCl) the voltammetric method showed a linear response for CAR in the range of 50-325 µmol·L −1 (R = 0.9755), with detection and quantification limits of 16.14 µmol·L −1 and 53.8 µmol·L −1 , respectively. The developed method was successfully applied for determination of CAR in real samples of pharmaceuticals. The sensor presented good sensitivity, rapid detection of CAR, and quick and easy preparation. Furthermore, the material used as modifier has a simple synthesis and its amount utilized is very small, thus illustrating the economic feasibility of this sensor.

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A Simple Route of Modifying Copper Electrodes for the Determination of Methanol and Ethylene Glycol

Wang

2012

Electroanalysis

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Copper foil electrodes were modified in a stirred NaOH solution at room temperature. Measurements with scanning electron microscopy, energy‐dispersive X‐ray spectroscopy and X‐ray photoelectron spectroscopy confirmed the simultaneous structural transformation and chemical modification of the foil surface. The as‐prepared electrodes produced isolated anodic peaks in the cyclic voltammogram of methanol or ethylene glycol in alkaline solution. The highest anodic peak current was achieved at the electrode that was modified for 5 hours. Amperometric study illustrates that the modified electrode can detect lower than 100 µM methanol with a sensitivity of 15.8 µA/mM or 10 µM ethylene glycol with a sensitivity of 193 µA/mM. Importantly, the method is robust and the prepared electrodes show great reproducibility.

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Electrochemical behavior of atenolol, carvedilol and propranolol on copper-oxide nanoparticles

Cited by 55 publications

References 25 publications

The Ultra-sensitive method development using Nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

The Ultra-sensitive method development using Nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

Development and Application of Electrochemical Sensor Based on Molecularly Imprinted Polymer and Carbon Nanotubes for the Determination of Carvedilol

A Simple Route of Modifying Copper Electrodes for the Determination of Methanol and Ethylene Glycol

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