Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

Abstract

The electrochemical behavior of lansoprazole (LNS) was investigated at a glassy carbon electrode (GCE) and the GCE modified by a gel containing multiwalled carbon nanotubes (MWCNTs) and a room-temperature ionic liquid (RTIL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF 6 ) in 0.10 M phosphate buffer solution of pH 6.8. It was found that an irreversible anodic oxidation peak with an E pa of 1.060 V SCE appeared at the MWCNTs--RTIL/GCE. Under the optimized experimental conditions a linear calibration curve was obtained over the concentration range from 5.0 μM to 0.20 mM by differential pulse voltammetry with a limit of detection (LOD, S/N = 3) of 0.28 μM. In addition, the novel MWCNTs-RTIL/GCE was also characterized by electrochemical impedance spectroscopy and the proposed method was successfully applied in the quantitative electrochemical determination of LNS content in commercial tablet samples. The determination results met the determination requirements.

Electroanalytical Investigation of 2‐(2‐Methylbenzyl)‐4(7)‐phenyl‐1H‐benzo[d]imidazole, a Novel Benzimidazole Derivative

“…In order to understand the possible responsible group in the oxidation of MPB, CV curves were obtained in different supporting electrolytes, which were solutions of 0.5 M H 2 SO 4 , pH 3.0 PB, and pH 3.5 AcB, and both MPB and model compounds showed similar behavior. According to the results obtained, it was concluded that the possible oxidation of MPB occurred through the nitrogen atom of the benzimidazole group forming a radical cation in acidic media, similar to that suggested in other compounds belonging to the benzimidazole family [21,31–34] …”

“…According to the results obtained, it was concluded that the possible oxidation of MPB occurred through the nitrogen atom of the benzimidazole group forming a radical cation in acidic media, similar to that suggested in other compounds belonging to the benzimidazole family. [21,[31][32][33][34]…”

Development of p-amino acetanilide functionalized multi-walled carbon nanotubes as an effective carrier for lansoprazole release

“…Wu et al successfully created a new multi-walled carbon nanotube (MT) based therapeutic delivery system by agent hydroxy camptothecin (HCPT) of tethering anticancer onto the surface of MTs [26]. Li-Hong et al [27] investigated electrochemical kinetics behavior and quantitative determination of Lansoprazole (LNS) by several electrochemical methods using an application of MTs.…”

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

“…[26][27][28]30 Voltammetric techniques such as square-wave adsorptive stripping voltammetry, differential pulse voltammetry, and anodic voltammetry have also been used for assay of lansoprazole. 29,31,32 However, analytical methods based on HPLC, HPTLC, spectrophotometry, capillary electrophoresis, and flow analysis are either associated with multiple sample preparation steps and longer analysis time or very costly. The electrochemical methods using a mercury electrode for reduction of lansoprazole may be associated with the environmental pollution.…”

“…In addition, electroanalytical methods have been developed for estimation of lansoprazole. The polarographic behavior of lansoprazole was investigated at the dropping mercury electrode which has been exploited to develop methods for its assay in dosage forms. − , Voltammetric techniques such as square-wave adsorptive stripping voltammetry, differential pulse voltammetry, and anodic voltammetry have also been used for assay of lansoprazole. ,, However, analytical methods based on HPLC, HPTLC, spectrophotometry, capillary electrophoresis, and flow analysis are either associated with multiple sample preparation steps and longer analysis time or very costly. The electrochemical methods using a mercury electrode for reduction of lansoprazole may be associated with the environmental pollution.…”