Electrochemical Behaviour of the Anticancer Dacarbazine‐Cu²⁺ Complex and Its Analytical Applications

Abstract

Electrochemical reduction of the dacarbazine-Cu 2 + complex was investigated using cyclic voltammetry and square wave voltammetry at a hanging mercury drop electrode. The reduction of the dacarbazine-Cu 2 + complex is irreversible. A reduction mechanism is proposed comprising a one-electron reduction of the Cu 2 + directly within the complex. The sharp peak of the adsorbed dacarbazine-Cu 2 + complex associated with an effective interfacial accumulation facilitates the determination of the anticancer drug dacarbazine in pharmaceutical formulations and biological fluids. Detection limits for dacarbazine of 6.12 10 À10 M, 1.57 10 À10 M and 1.97 10 À9 M were achieved for the determination of the drug in vial, human urine and serum, respectively.

Electrochemical Detection of Interaction between Dacarbazine and Nucleic Acids in Comparison to Agarose Gel Electrophoresis

“…According to this procedure, the LOD was calculated as 1.10 μM with a regression equation y=539.6 x+584.5 and the coefficient of determination (R 2 ) of 0.986. In comparison to earlier reports , the LOD was compared to each other, and some of these literatures were summarized in Table .…”

Square-wave cathodic adsorptive stripping voltammetric determination of 3-hydroxyflavone, Morin and Hesperidin in bulk form and biological fluids in absence and presence of Cu(II)

“…Direct electroanalytical determination of flavonoids by differential pulse voltammetry or stripping techniques has only rarely been reported. [12][13][14][15][16][17][18] In continuation of our studies on the electrochemical determination of flavonoids it would be of interest to investigate the stripping voltammetry with adsorptive accumulation of three flavonoids in absence and presence of Cu(II). 18 In the present paper, a validated square-wave adsorptive cathodic stripping voltammetric procedure was described for determination of 3HF, morin and Hesp in bulk forms and in biological fluids.…”

Voltammetric and Impedimetric Detection of Interaction Between Dacarbazine and Nucleic Acids

“…As a conclusion, single use pencil graphite electrodes utilized herein for monitoring biorecognition processes owing to its many advantages; such as cost effectiveness, rapid and sensitive detection with good repeatability of drug-DNA interaction in comparison to earlier studies performed by using other electrodes, such as GCE, HMDE and CPE [7,[18][19][20][28][29][30][31][32]. The electrochemical monitoring of the surface-confined interaction between DNA and DNA-targeted molecules would be valuable in the rational design of the molecule-specific electrochemical biosensor, and in the further development of novel drugs for the chemotherapy.…”