Electrochemical biosensor for the detection of H2O2 from living cancer cells based on ZnO nanosheets

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

“…51,[107][108][109] For example, cancer patients (such as those with breast and lung tumors) stromal-based tamoxifen-resistance. In this context, we observed that the addition of tamoxifen plus dasastinib was indeed sufficient to prevent stromal-based tamoxifen-resistance and restore sensitivity toward tamoxifen-induced apoptosis in cancer cells.…”

A Non-Enzyme Hydrogen Peroxide Biosensor Based on Fe3O4/RGO Nanocomposite Material

“…1 Enzymebased electrochemical sensors have been developed for monitoring H 2 O 2 due to their high sensitivity and selectivity. 2 However, enzymes are sensitive to the environmental conditions and the instability of enzyme-based biosensors is inevitable. 3 Therefore, more and more attentions have been paid on the non-enzyme electrochemical sensors with high efficiency.…”

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

“…CM-H 2 DCFDA is a non-fluorescent molecule (DCFH) that, when taken up by cells, is rapidly oxidized to a diagnosis and therapy. 47,[95][96][97] For example, new fluorescent probes have been developed to visualize xenografted tumors, based on their ability to produce hydrogen peroxide. 98 Similarly, human breast and lung cancer patients can be positively identified by examining their exhaled breath for the presence of hydrogen peroxide.…”