Electrochemical Biosensors Based on Micro‐fabricated Devices for Point‐of‐Care Testing: A Review

Zhang, Yuting; Zhou, Nandi

doi:10.1002/elan.202100281

Cited by 19 publications

(8 citation statements)

References 144 publications

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“…Electrochemical techniques provide favorable ways for figuring out the composition and concentration of a target species by measuring electrochemical parameters such as electrode potential, current, conductivity, and charge. 118,119 Electrochemical evaluations are frequently utilized in wearable biosensors and hold an indispensable position because of their remarkable sensitivity, rapid response, compatibility with microfabrication, batch fabrication, cost-effectiveness, and miniaturization. The electrochemical biosensor has proven to be a successful platform, with its market share in the field of biosensing technology continuing to grow.…”

Section: Portable Electrochemical Immunoassaysmentioning

confidence: 99%

Flexible electronic materials and devices toward portable immunoassays

Huang,

Tang,

Yang

2024

FlexMat

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Biomarker identification is a tried‐and‐true method that can provide precise biological information for disease diagnosis. Prompt diagnosis, disease progression monitoring, therapy efficacy evaluation, and prognosis assessment of cancers all benefit from sensitive, rapid, and precise measurement of significant biomarkers employing chemical and immunological approaches. The study of biomolecules and immunoassay evaluations can profit greatly from recent advancements in flexible electronic materials and technologies, which provide amazing flexibility, affordability, mobility, and integration. However, an overview of the implementation of portable immunoassays in conjunction with flexible electronic devices is rare to come by. This review focuses on recent breakthroughs in flexible electronic materials and devices for portable biomarker testing, which provides an extensive summary of flexible electrical components and sensing‐capable devices, emphasizing their adaptability in the construction of biosensing platforms. These platforms employ various signal transduction systems to record biological affinity recognition events, including pressure, temperature, electrical parameters, colorimetric signals, and other physical features. The challenges for portable, integrated, intelligent, and multifunctional immunoassays based on flexible sensing devices are also discussed. The portable immunoassays with flexible electronics would unlock the potential to transform clinical diagnostics into non‐clinical personalized treatments and achieve home‐based point‐of‐care testing for daily monitoring.

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Section: Portable Electrochemical Immunoassaysmentioning

confidence: 99%

Flexible electronic materials and devices toward portable immunoassays

Huang,

Tang,

Yang

2024

FlexMat

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“…Although nanobioengineered biosensors are an affordable analytical strategy relative to gold standard detection methods, the development of large-scale electrochemical nanobiosensors is still challenging because they require state-of-the-art technologies for their production in a reproducible and stable manner, directly influencing the cost of the sensing device [178,181]. This apparent drawback could be overcome by scaling, automation, and mass manufacturing to lower costs through advanced methods in elaborating cost-affordable and disposable electrochemical nanobiosensors based on additive manufacturing, including screen inkjet 3D printing or microfabrication technologies [44,[181][182][183].…”

Section: Limitations Opportunities and Concluding Remarksmentioning

confidence: 99%

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Soto

Orozco

2022

Molecules

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Nanoengineering biosensors have become more precise and sophisticated, raising the demand for highly sensitive architectures to monitor target analytes at extremely low concentrations often required, for example, for biomedical applications. We review recent advances in functional nanomaterials, mainly based on novel organic-inorganic hybrids with enhanced electro-physicochemical properties toward fulfilling this need. In this context, this review classifies some recently engineered organic-inorganic metallic-, silicon-, carbonaceous-, and polymeric-nanomaterials and describes their structural properties and features when incorporated into biosensing systems. It further shows the latest advances in ultrasensitive electrochemical biosensors engineered from such innovative nanomaterials highlighting their advantages concerning the concomitant constituents acting alone, fulfilling the gap from other reviews in the literature. Finally, it mentioned the limitations and opportunities of hybrid nanomaterials from the point of view of current nanotechnology and future considerations for advancing their use in enhanced electrochemical platforms.

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“…Point-of-care testing (POCT) is a method for real-time analysis of patient specimens outside the laboratory, near or at the site of the patient. 1 Thanks to its speediness, high efficiency, low cost, excellent convenience, and low operation requirements, POCT has been widely used in clinical diagnosis, infectious disease surveillance, drug screening, food security, and many other fields. [2][3][4] POCT devices are highly desirable in the global market, especially for in vitro diagnostics (IVD).…”

Section: Introductionmentioning

confidence: 99%