Copper hydroxyapatite coatings (CuHAp) were synthesized on 316L stainless steel by electrodepositon and ion exchange methods. Effect of Cu 2+ initial concentration and contact time to ion exchange process was investigated. The FTIR, SEM, XRD and EDX measurements of the synthesized samples showed that CuHAp coatings were single crystalline phase of HAp with %Cu of 0.08 (% mass) in Cu 2+ initial solution of 0.05 M. The presence of Cu 2+ reduced the HAp crystalline size and enabled to obtain samples with more uniform surface. The antimicrobial activity of CuHAp coatings was tested. CuHAp coatings had good resistance to E. coli and S. aureus that antibacterial ratio reached 89 % and 98 %, respectively.