Electrochemical detection and screening of bladder cancer recurrence using direct electrochemical analysis of urine: A non-invasive tool for diagnosis

Doménech‐Carbó, Antonio; Pontones, J.L.; Doménech-Casasús, Clara; Villaroya, Sara; Ramos, David

doi:10.1016/j.snb.2018.03.048

Cited by 12 publications

(4 citation statements)

References 56 publications

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“…Non-invasive diagnosis allows for the direct detection of target biomarkers from body uids without the common pain and infection risk associated with blood-based protocols (Li et al 2019;Michelena et al 2019;Eftekhari et al 2019;Doménech-Carbó et al 2018). Various substrates have been used for noninvasive diagnosis including tattoos (Bandodkar et al 2013;Jia et al 2013), paper-based sensors (Anastasova et al 2017), stretchable elastomers (Martin et al 2017) and textile substrates (Liu and Lillehoj 2017).…”

Section: Introductionmentioning

confidence: 99%

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

et al. 2021

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We report on the development of an electrochemical sensor platform based on modi ed cotton bers for the non-enzymatic detection of uric acid (UA), an important biomarker for gout disease. To create the exible electrode, a cotton thread was coated with carbon ink followed by the electrodeposition of AuNPs.Then, differential pulse voltammetry (DPV) was used to evaluate the sensor performances, and a linear detection range between 10 µM and 5.0 mM of uric acid was obtained. The sensor has a low detection limit of 0.12 µM, which is optimal for use in the patients suffering from gout disease which commonly experience concentrations of uric acid in urine higher than 4.46 mM. Furthermore, we found that the detection sensitivity of the platform was not affected by the presence of other physiological compounds present in human urine. The described platform has the potential for integration in a diaper hence enabling rapid detection and screening for gout disease.

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Section: Introductionmentioning

confidence: 99%

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Teekayupak

Ruecha

Chailapakul

et al. 2021

Preprint

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We report on the development of an electrochemical sensor platform based on modified cotton fibers for the non-enzymatic detection of uric acid (UA), an important biomarker for gout disease. To create the flexible electrode, a cotton thread was coated with carbon ink followed by the electrodeposition of AuNPs. Then, differential pulse voltammetry (DPV) was used to evaluate the sensor performances, and a linear detection range between 10 µM and 5.0 mM of uric acid was obtained. The sensor has a low detection limit of 0.12 µM, which is optimal for use in the patients suffering from gout disease which commonly experience concentrations of uric acid in urine higher than 4.46 mM. Furthermore, we found that the detection sensitivity of the platform was not affected by the presence of other physiological compounds present in human urine. The described platform has the potential for integration in a diaper hence enabling rapid detection and screening for gout disease.

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“…Accordingly, the development of analytical methods oriented to their effective implementation into the clinical practice is of interest in particular in regard to routine analysis. With this objective, we have previously reported electrochemical methodologies for screening antimalarial drugs [20] and detecting hemolysis in blood [21], and bladder cancer in urine [22].…”

Section: Introductionmentioning

confidence: 99%

Biomedical application of VIMP: screening of malignant cells in the prostate

Doménech‐Carbó

Doménech-Casasús²,

Pontones

et al. 2020

J Solid State Electrochem

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An electrochemical method for discriminating healthy and malignant tissues in prostate biopsies using the voltammetry of immobilized particles methodology is described. The method involves the sampling with graphite bars 0.5 mm in diameter on paraffin-impregnated cross sections of prostate tissues used in ordinary cytological evaluation after local staining with methylene blue (MB). The subsequent record of the voltammetric response of sample-modified graphite electrodes displays clearly different MB-centered features for healthy and malignant regions due to the different association of the dye to the respective cells.

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Electrochemical detection and screening of bladder cancer recurrence using direct electrochemical analysis of urine: A non-invasive tool for diagnosis

Cited by 12 publications

References 56 publications

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Biomedical application of VIMP: screening of malignant cells in the prostate

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