Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Ouellette, Mathieu; Mathault, Jessy; Niyonambaza, Shimwe Dominique; Miled, Amine; Boisselier, Élodie

doi:10.3390/coatings9080496

Cited by 30 publications

(9 citation statements)

References 46 publications

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“…Of note, since DNA is highly negatively charged and dopamine is positively charged under the physiological condition, DNA (non‐aptamer)‐modified electrodes have been used for detecting dopamine taking advantage of such nonspecific binding 122,123 . Therefore, careful control experiments such as using mutated aptamers are needed to ensure specific binding of aptamers.…”

Section: Electochemical Biosensors Based On Oxidation Of Dopaminementioning

confidence: 99%

Biosensors and sensors for dopamine detection

Liu

2020

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196

122

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Dopamine is a key catecholamine neurotransmitter and it has critical roles in the function of the human central nervous system. Abnormal release of dopamine is related to neurological diseases and depression. Therefore, it is necessary to monitor dopamine levels in vivo and in real time to understand its physiological roles. In this review, we discuss dopamine detection focusing on the molecular recognition methods including enzymes, antibodies, and aptamers, as well as new advances based on nanomaterials and molecularly imprinted polymers (MIPs). A large fraction of these sensors rely on electrochemical detection to fulfill the requirement of fast, in situ, and in vivo detection with a high spatial and temporal resolution. These methods need to overcome interferences from molecules with a similar redox potential. In addition, fluorescent and colorimetric sensors based on aptamers are also quite popular, and care needs to be taken to validate specific dopamine binding. Combining aptamers or MIPs with electrochemistry promises to achieve rapid detection and increased selectivity. In this article, we pay more attention to the molecular recognition mechanism and critically review the sensor designs. In the end, some future directions are discussed.

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Section: Electochemical Biosensors Based On Oxidation Of Dopaminementioning

confidence: 99%

Biosensors and sensors for dopamine detection

Liu

2020

VIEW

196

122

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“…Dopamine is critical for the regulation of human movement and emotional responses [ 102 ]. As a result, the analysis of dopamine levels in the human body, remarkably the cerebrospinal fluid (CSF), is critical for the early detection and treatment of a variety of neural diseases [ 103 , 104 ]. Pagano et al recently proposed a novel approach for developing a dopamine detection system based on SERS-LSPR by fabricating a hybrid layer of perylene bisimide (PBI) derivative and multishaped Au nanostructures (AuNS) [ 45 ].…”

Section: Surface Plasmon Resonance (Spr): Theory and Working Principlementioning

confidence: 99%

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

Mulyanti

Nugroho

Wulandari

et al. 2022

International Journal of Biomaterials

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SPR-based technology has emerged as one of the most versatile optical tools for analyzing the binding mechanism of molecular interaction due to its inherent advantages in sensing applications, such as real-time, label-free, and high sensitivity characteristics. SPR is widely used in various fields, including healthcare, environmental management, and food-borne illness analysis. Meanwhile, kidney disease has grown to be one of the world’s most serious public health problems in recent decades, resulting in physical degeneration and even death. As a result, several studies have published their findings regarding developing of reliable sensor technology based on the SPR phenomenon. However, an integrated and comprehensive discussion regarding the application of SPR-based sensors for detecting of kidney disease has not yet been found. Therefore, this review will discuss the recent advancements in the development of SPR-based sensors for monitoring kidney-related diseases. Numerous SPR configurations will be discussed, including Kretschmann, Otto, optical fiber-based SPR, and LSPR, which are all used to detect analytes associated with kidney disease, including urea, creatinine, glucose, uric acid, and dopamine. This review aims to show the broad application of SPR sensors which encouraged the development of SPR sensors for kidney problems monitoring.

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“…As a result, irregular DA levels may precipitate various disorders with complex functions, such as Alzheimer's disease, depression, Parkinson's disease, and others [2]. Numerous analytical methods, such as spectroscopy, fluorescence analysis [3], capillary electrophoresis [4], and high-pressure liquid chromatography [HPLC] [5], have been used for the detection of DA. Nevertheless, these procedures are high-cost, complex, tedious, and require special equipment, even though the spectrophotometry technique has recently been improved to be detectable and straightforward with a high limit of detection [6].…”

Section: Introductionmentioning

confidence: 99%

Gold-Modified Molecularly Imprinted N-Methacryloyl-(l)-phenylalanine-containing Electrodes for Electrochemical Detection of Dopamine

et al. 2022

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A molecularly imprinted polymer-based pencil graphite electrode (MIP PGE) sensor, modified with gold nanoparticles, was utilized for the detection of dopamine in the presence of other biochemical compounds using cyclic voltammetry (CV) and differential pulse voltammetry (DPV), depending on its strong electroactivity function. The pulse voltammetry methods recorded the highest response. In addition to the high oxidation rate of DA and the other biomolecule interferences available in the sample matrix used, which cause overlapping voltammograms, we aimed to differentiate them in a highly sensitive limit of detection range. The calibration curves for DA were obtained using the CV and DPV over the concentration range of 0.395–3.96 nM in 0.1 M phosphate buffer solution (PBS) at pH 7.4 with a correlation coefficient of 0.996 and a detection limit of 0.193 nM. The electrochemical technique was employed to detect DA molecules quantitatively in human blood plasma selected as real samples without applying any pre-treatment processes. MIP electrodes proved their ability to detect DA with high selectivity, even with epinephrine and norepinephrine competitor molecules and interferences, such as ascorbic acid (AA). The high level of recognition achieved by molecularly imprinted polymers (MIPs) is essential for many biological and pharmaceutical studies.

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Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Cited by 30 publications

References 46 publications

Biosensors and sensors for dopamine detection

Biosensors and sensors for dopamine detection

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

Gold-Modified Molecularly Imprinted N-Methacryloyl-(l)-phenylalanine-containing Electrodes for Electrochemical Detection of Dopamine

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