Electrochemical detection of dopamine in the presence of epinephrine, uric acid and ascorbic acid using a graphene-modified electrode

Ma, Xinying; Chao, Mingyong; Wang, Zhao-xia

doi:10.1039/c2ay25040c

Cited by 96 publications

(36 citation statements)

References 31 publications

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“…Xinying et al fabricated a graphene-based electrode to detect DA in the presence of a number of potential interferents such as EP, UA, and AA. Moreover, the DA in rabbit serum was also analyzed with a recovery of 97.8% [53]. A generator-collector approach was established for selective DA detection in the presence of AA using microwell arrays with the concept based on redox cycling.…”

Section: In Vitro Detection Of Typical Neurotransmittersmentioning

confidence: 99%

Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

et al. 2018

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Neurotransmitters are molecules that transfer chemical signals between neurons to convey messages for any action conducted by the nervous system. All neurotransmitters are medically important; the detection and analysis of these molecules play vital roles in the diagnosis and treatment of diseases. Among analytical strategies, electrochemical techniques have been identified as simple, inexpensive, and less time-consuming processes. Electrochemical analysis is based on the redox behaviors of neurotransmitters, as well as their metabolites. A variety of electrochemical techniques are available for the detection of biomolecules. However, the development of a sensing platform with high sensitivity and selectivity is challenging, and it has been found to be a bottleneck step in the analysis of neurotransmitters. Nanomaterials-based sensor platforms are fascinating for researchers because of their ability to perform the electrochemical analysis of neurotransmitters due to their improved detection efficacy, and they have been widely reported on for their sensitive detection of epinephrine, dopamine, serotonin, glutamate, acetylcholine, nitric oxide, and purines. The advancement of electroanalytical technologies and the innovation of functional nanomaterials have been assisting greatly in in vivo and in vitro analyses of neurotransmitters, especially for point-of-care clinical applications. In this review, firstly, we focus on the most commonly employed electrochemical analysis techniques, in conjunction with their working principles and abilities for the detection of neurotransmitters. Subsequently, we concentrate on the fabrication and development of nanomaterials-based electrochemical sensors and their advantages over other detection techniques. Finally, we address the challenges and the future outlook in the development of electrochemical sensors for the efficient detection of neurotransmitters.

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Section: In Vitro Detection Of Typical Neurotransmittersmentioning

confidence: 99%

Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

et al. 2018

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“…Voltammetry is a potentiodynamic technique, based on measuring the current arising from oxidation or reduction reactions at the working electrode surface, when a controlled potential variation is imposed [39,40]. Amperometry is based on the application of a constant potential to a working electrode, and the subsequent measurement of the current generated by the oxidation/reduction of an electroactive analyte [41][42][43].…”

Section: Voltammetric and Amperometric Sensorsmentioning

confidence: 99%

Voltammetric and amperometric sensors for determination of epinephrine: A short review (2013-2017)

Beitollahi

Safaei

Tajik

2018

J. Electrochem. Sci. Eng.

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<p><span lang="EN-US">The present review focuses on voltammetric and amperometric methods applied for determination of epinephrine (EP) in last five years (2013-2017). Occurrence, role and biological importance of EP, as well as non-electrochemical methods for its assessment, are firstly reviewed. The electrochemical behavior of EP is then illustrated, followed by a description of the voltammetric and amperometric methods for EP content estimation in various media. Different methods for development of electrochemical sensors are reviewed, starting from unmodified electrodes to different composites incorporating carbon nanotubes, ionic liquids or various mediators. From this perspective, the interaction between functional groups of the sensor material and the analyte molecule is discussed, as it is essential for analytical characteristics obtained. The analytical performances of the voltammetric or amperometric chemical and biochemical sensors (linear range of analytical response, sensitivity, precision, stability, response time, etc.) are highlighted. Numerous applications of EP electrochemical sensors in fields like pharmaceutical or clinical analysis where EP represents a key analyte, are also presented.</span></p>

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“…Employing graphene directly modified electrodes, electrochemical determination of DA has been achieved [59][60][61][62]. In these studies, it was revealed that the interaction between DA and graphene accelerated the electron transfer process and graphenemodified electrode exhibited excellent electrocatalytic activity toward the electrochemical oxidation of DA.…”

Section: Damentioning

confidence: 99%

Graphene for Glucose, Dopamine, Ascorbic Acid, and Uric Acid Detection

Han

et al. 2014

SpringerBriefs in Molecular Science

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Since every atom in graphene single sheet is a surface atom, molecular interaction and electron transport through graphene can be highly sensitive to adsorbed biomolecules. Graphene materials act as good candidates for glucose sensing due to the high surface area, excellent conductivity, and small band gap, which are favorable for biomolecules loading and electrons conducting. Generally, graphene-based platforms for glucose determination could be categorized into two kinds, namely enzyme catalysis and non-enzyme catalysis. The enzyme catalysis shows high sensitivity and selectivity. However, the inevitable drawbacks of instability originating from the intrinsic nature of the enzyme, as well as the critical operational conditions and complicated immobilization procedure, may limit the analytical applications. These drawbacks could be overcome in non-enzyme catalytic biosensors, which are stable, simple, reliable, and cost-effective. Detailed descriptions are illustrated in the following. The concentrations of dopamine (DA), ascorbic acid (AA), and uric acid (UA) in human body are important in the diagnosis, monitoring, prevention, and treatments of some certain diseases, such as HIV infections, schizophrenia, Parkinson, hyperuricemia, and a type of arthritis. Then various graphene platforms for the detection and quantification of DA, AA, and UA are also demonstrated.Keywords Graphene Á Glucose Á Enzyme Á Dopamine Á Ascorbic acid Á Uric acid Glucose Detection Catalysis by EnzymesGlucose detection plays an important role in biotechnology, life science, food industry, and clinical diagnostics. Diabetes is a worldwide public health problem and one of the leading causes of death and disability in the world. In 2000, it was estimated that 2.8 % of the world population was affected by diabetes mellitus, a disease with hyperglycemia (i.e., elevated blood glucose level) as the major symptom

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Electrochemical detection of dopamine in the presence of epinephrine, uric acid and ascorbic acid using a graphene-modified electrode

Cited by 96 publications

References 31 publications

Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

Voltammetric and amperometric sensors for determination of epinephrine: A short review (2013-2017)

Graphene for Glucose, Dopamine, Ascorbic Acid, and Uric Acid Detection

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