Electrochemical detectors ? tailormade techniques for liquid chromatography and capillary electrophoresis?

Abstract

Electrochemical detectors for liquid chromatography and capillary electrophoresis are reviewed with special emphasis on electrode materials that allow the amperometric detection of otherwise non-electroactive compounds such as aliphatic alcohols, carbohydrates or amino acids. Noble metal electrodes can catalyze the oxidation of aliphatic compounds in alkaline media if multistep potential-time waveforms are employed. Various metal and metal oxide electrodes such as Ni, Cu or Co allow the detection of carbohydrates and similar compounds under constant potential conditions. Metallic copper electrodes operating in an amperometric mode or in a potentiometric mode can also serve as selective detectors for complexing species. A range of applications in combination with chromatography and electrophoresis is summarized. The current state of electrochemical detectors indicates that both amperometric and potentiometric detectors are on the verge of becoming tailormade detectors for micro-separation techniques.

Amperometric glucose sensor based on enzyme-modified boron-doped diamond electrode by cross-linking method

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Detection challenges in quantitative polymer analysis by liquid chromatography

“…There is wide variety of electrochemical detectors (not including conductivity detection, described in Section 3.12) such as potentiometric, amperometric, coulometric, and voltammetric detectors, as well as a variety of operation modes and electrodes [142,143]. This review will not cover these electrochemical detectors exhaustively, but instead focus on their potential application to polymer LC.…”

The effect of temperature on the analysis of metanephrine for catechol‐O‐methyltransferase activity assay by HPLC with electrochemical detection

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