Electrochemical Determination of Dexrazoxane by Differential Pulse Voltammetry (DPV) Using a Graphene Oxide Nanosheet Modified Pencil Graphite Electrode (PGE)

Akpınar, Fatma; Şensoy, Kübra Gençdağ; Muti, Mihrican

doi:10.1080/00032719.2022.2095567

Cited by 5 publications

(1 citation statement)

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“…Electrochemical methods have advantages such as their eco-friendly nature, low cost, high sensitivity, simplicity, and relatively short analysis time [29][30]. Carbon-based electrodes have been widely used in electro-analysis because of their applicability to the determination of drug molecules that undergo either reduction or oxidation.…”

Section: Introductionmentioning

confidence: 99%

Development of ZnO-adorned glassy carbon electrode for voltammetric sensing and electro-kinetic investigations of antihypertensive drug efonidipine

Agarwal,

Jhankal,

Yadav

et al. 2023

Monatsh Chem

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The fast, accurate, and affordable determination of efonidipine (EFO) is the need of the time for human mental health. In this work, we proposed a ZnO-adorned glassy carbon electrode (ZnO/GCE) for the voltammetric sensing and electro-kinetic investigations of efonidipine in pharmaceutical samples. ZnOdecorated glassy carbon electrode exhibit enhanced electro-catalytic activity, higher surface area, rapid electron transfer rate, and enhanced electrical conductivity, these properties result in an ampli ed peak current response for the electro-reduction of EFO. The ZnO nanoparticles are synthesized by a simple and economical sol-gel method and characterized by XRD, SEM, and EDS techniques. The electro-kinetic studies of efonidipine on the ZnO fabricated glassy carbon electrode was investigated using CV, EIS, LSV, DPSV, and Chronocoulometry techniques. The diffusion-controlled electro-reduction of EFO produced three well-de ned peaks in the cyclic voltammograms. The various electro-kinetics parameters like diffusion coe cient (D o ), heterogeneous rate constant (K h ), electron transfer coe cient (α), and surface coverage (Γ) were evaluated and the mechanism of electro-reduction was proposed. The peak current in LSV and DPSV techniques shows a linear relationship with the concentration of EFO in the range of 0.14-0.98 µmolL − 1 with detection limits of 0.21 and 0.07 µmolL − 1 , respectively. The proposed ZnO/GCE sensor demonstrates a cost-effective and environmentally compatible approach for the detection of efonidipine in pharmaceutical samples.

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Section: Introductionmentioning

confidence: 99%