Electrochemical determination of folic acid: A short review

Akbar, Samina; Anwar, Abdul Waheed; Kanwal, Qudsia

doi:10.1016/j.ab.2016.07.002

Cited by 75 publications

(52 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[53] The results confirmed that the proportion electrons to protons 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 involved in the UA and FA oxidation mechanism was calculated as about 1:1. [54,55] The simultaneous detection of UA and FA at GR-Cys-AuNPs/GCE To evaluate the performance of the GR-Cys-AuNPs/GCE for simultaneous determination of UA and FA. Under the optimal conditions, the electrochemical behaviors of UA and FA were measured by DPV at GR-Cys-AuNPs/GCE.…”

Section: Electrochemical Behavior Of the Gr-cys-aunps Nanocompositesmentioning

confidence: 99%

Functionalized Graphene Obtained via Thiol-Ene Click Reactions as an Efficient Electrochemical Sensor

Bao

Zhou

et al. 2017

ChemistrySelect

View full text Add to dashboard Cite

Functionalized graphene was synthesized via thiol‐click reactions, and then a simple approach was adopted to immobilize Au nanoparticles (AuNPs) on the surface of functionalized graphene sheets. This approach is to use cysteamine linker with reactive amine and thiol functional groups at each end. Firstly, cysteamine hydrochloride (HS–(CH2)2–NH2•HCl) was incorporated onto the surface of graphene reacted with the C=C bonds by using 2,2‐azobis(2‐methylpropionitrile) (AIBN) as thermal catalyst. Then, uniform and monodispersed AuNPs were anchored on functionalized graphene surface through electrostatic interaction under acidic conditions. The obtained functionalized graphene/AuNPs composites exhibited excellent electrochemical properties investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The composites electrode exhibited high stability and good selectivity for UA and FA with the detection limit of 0.08 μM and 0.035 μM (S/N=3), respectively. Our work provides a simple, convenient and green route to synthesize functional graphene which is potentially useful in electroanalysis.

show abstract

Section: Electrochemical Behavior Of the Gr-cys-aunps Nanocompositesmentioning

confidence: 99%

Functionalized Graphene Obtained via Thiol-Ene Click Reactions as an Efficient Electrochemical Sensor

Bao

Zhou

et al. 2017

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Researchers working in this are reported that modification of working electrodes are needed in order to overcome slow kinetics with a need of high reduction potentials of oxidation procedure of FA . Also, it has been found that two steps (adsorption and stripping) contained electroanalytical techniques like stripping voltammetry provide effective determination of FA . Based on these facts, we applied centri‐voltammetry, two steps electroanalytical method, for FA detection.…”

Section: Resultsmentioning

confidence: 99%

“…It can behave like coenzyme which involves in the generation of ferroheme [2]. Also together with vitamin B12, FA contributes to the synthesis processes of nucleic acids [1], production of healthy red blood cells [4], DNA repair and cell division [5][6][7][8]. Additionally, FA is important in growth process and for the healthy improvement of foetus [9].…”

Section: Introductionmentioning

confidence: 99%

Centri‐Voltammetric Folic Acid Detection

2019

View full text Add to dashboard Cite

The need for practical detection of folic acid (FA) has been increased day by day. For this reason in this work, a two steps electroanalytical technique, centri‐voltammetry was utilized for FA detection for the first time. In order to get rid of the slow electrode kinetics of FA oxidation, the working electrode was modified with graphene‐Pt hibrid nanomaterial. Also for increasing the sensitivity, 1‐Chloro‐2‐[2‐(2‐methoxyethoxy) ethoxy]ethane (TEG−Cl) and 1,2‐di{2‐[2‐(2‐methoxyethoxy)ethoxy] ethoxy}‐4‐nitrobenzene (4NC−NO2) was used as a carrier material. After the characterization of graphene‐Pt hybrid nanomaterial, experimental parameters like, 4NC−NO2 amount, adsorption time, centri‐voltammetric parameters like centrifuge time and speed were optimized. After that, analytical characteristics such as linear range, relative standard deviation (R.S.D), limit of detection (LOD) and limit of quantification (LOQ) values were found. In this manner, linear range was obtained for FA between 1.0 μM–1000 μM with the equations of y=0.0108x+1.0459 (R2=0.9977). R.S.D value was calculated for 0.83 mM FA (n=3) as 1.86 % while LOD and LOQ values were found as 1.00 μM and 3.34 μM respectively. After the examination of interference effect of substances like ascorbic acid and uric acid, established centri‐voltammetric technique was enforced for FA detection in pharmateutical tablets. As a result, the recovery value was calculated as 96.4 %.

show abstract

“…A deficiency in FA can cause megaloblastic anemia and leucopenia, which is particularly important for pregnant women. Therefore, monitoring the FA level is vital for the immunodiagnosis and treatment of cancers and chronic inflammatory diseases [ 117 ]. For example, a fluorescence biosensor for folate receptor (FR) in cancer cells based on terminal protection and HRCA was developed by Li et al [ 118 ].…”

Section: Other Novel Biosensors Based On Rcamentioning

confidence: 99%

Research Progress on Rolling Circle Amplification (RCA)-Based Biomedical Sensing

Yan

Liu

et al. 2018

Pharmaceuticals

View full text Add to dashboard Cite

Enhancing the limit of detection (LOD) is significant for crucial diseases. Cancer development could take more than 10 years, from one mutant cell to a visible tumor. Early diagnosis facilitates more effective treatment and leads to higher survival rate for cancer patients. Rolling circle amplification (RCA) is a simple and efficient isothermal enzymatic process that utilizes nuclease to generate long single stranded DNA (ssDNA) or RNA. The functional nucleic acid unit (aptamer, DNAzyme) could be replicated hundreds of times in a short period, and a lower LOD could be achieved if those units are combined with an enzymatic reaction, Surface Plasmon Resonance, electrochemical, or fluorescence detection, and other different kinds of biosensor. Multifarious RCA-based platforms have been developed to detect a variety of targets including DNA, RNA, SNP, proteins, pathogens, cytokines, micromolecules, and diseased cells. In this review, improvements in using the RCA technique for medical biosensors and biomedical applications were summarized and future trends in related research fields described.

show abstract

Electrochemical determination of folic acid: A short review

Cited by 75 publications

References 53 publications

Functionalized Graphene Obtained via Thiol-Ene Click Reactions as an Efficient Electrochemical Sensor

Functionalized Graphene Obtained via Thiol-Ene Click Reactions as an Efficient Electrochemical Sensor

Centri‐Voltammetric Folic Acid Detection

Research Progress on Rolling Circle Amplification (RCA)-Based Biomedical Sensing

Contact Info

Product

Resources

About