Electrochemical Determination of the Antidiabetic Drug Repaglinide

Abstract

The electrochemical oxidation of repaglinide has been carried out in Britton-Robinson buŠer at carbon paste and glassy carbon electrodes. Repaglinide exhibits a well-deˆned irreversible oxidation peak over the entire pH range (2 11). DiŠerential pulse voltammetry was used to determine repaglinide in pure form. The peak current varied linearly in the following ranges: 8.0×10 -7  3.2×10-6 M and 4.0×10 -7  4.0×10 -6 M in case of carbon paste electrode and glassy carbon electrode, respectively. In case of carbon paste electrode the limits of detection (LOD) and quantiˆcation (LOQ) were 1.348×10 -7 M and 4.494×10 -7 M, respectively. For glassy carbon electrode the LOD and LOQ were 1.062×10 -7 M and 3.54×10 -7 M, respectively. The percentage recoveries were found in the following ranges: 99.09 100.07％ and 99.0 100.50％ for carbon paste electrode and glassy carbon electrode, respectively. The relative standard deviations were found in the following ranges: 0.636 1.395％ and 0.431 1.104％ in case of carbon paste electrode and glassy carbon electrode, respectively. DiŠerential pulse voltammetry was successfully applied for the determination of repaglinide in tablets and human serum.

Simultaneous Electrochemical Determination of Articaine HCl and Epinephrine

“…characteristics and benefits such as the ease of surface renewal, individual polarizability, and easy to apply modifications. The disadvantage of CPE is the tendency of the organic binder to dissolve in solutions containing an appreciable fraction of organic solvent [31].…”

Validated spectrophotometric methods for determination of some oral hypoglycemic drugs

“…Many analytical methods have been reported for the quantitative estimation of RPG in pharmaceutical preparations and biological samples (3)(4)(5) which include visible spectrophotometric (6,7), HPLC (8,9) and electrochemical methods (10). PGL and its metabolites have been determined in biological fluids and pharmaceutical preparations by HPLC with UV detection (11)(12)(13), reversed phase TLC (14), liquid chromatography coupled with mass spectrometry (15), and spectrometry (16).…”

Fourier transform infrared spectroscopy for in-process inspection, counterfeit detection and quality control of anti-diabetic drugs

“…An HPLC method for the determination of RPG was described in the United Sates Pharmacopoeia (USP) [27]. Electrochemical, spectrophotometric and chromatographic methods have also been reported for the determination of RPG [5,7,11,19,20]. RGZ has been determined by first-order UV spectroscopy and chromatography [6,10,12].…”