Electrochemical DNA biosensor for potential carcinogen detection in food sample

Sani, Nor Diyana Md; Heng, Lee Yook; Marugan, Radha Swathe Priya Malon; Rajab, Nor Fadilah

doi:10.1016/j.foodchem.2018.07.035

Cited by 31 publications

(15 citation statements)

References 35 publications

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“…fumonisin B1 and ochratoxin A) contamination in food such as cereals ( Liu et al, 2015 ; Shu et al, 2016 ). Many genotoxic carcinogens may also be detected via DNA binding assays with a new biosensor assay detecting carcinogens in contaminated food samples with a 24-base guanine rich DNA segment at ranges as low as 0.0001 ppm ( Sani, Heng, Marugan, & Rajab, 2018 ). DNA adducts formed from genotoxic carcinogens can be identified in exposed people.…”

Section: Detection Of Carcinogensmentioning

confidence: 99%

Carcinogenesis: Failure of resolution of inflammation?

Fishbein

Hammock

Serhan

et al. 2021

Pharmacology & Therapeutics

138

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Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a key characteristic of carcinogens. However, the failure of resolution of inflammation in cancer is only recently being understood. Products of arachidonic acid and related fatty acid metabolism called eicosanoids, including prostaglandins, leukotrienes, lipoxins, and epoxyeicosanoids, critically regulate inflammation, as well as its resolution. The resolution of inflammation is now appreciated to be an active biochemical process regulated by endogenous specialized pro-resolving lipid autacoid mediators which combat infections and stimulate tissue repair/regeneration. Environmental and chemical human carcinogens, including aflatoxins, asbestos, nitrosamines, alcohol, and tobacco, induce tumor-promoting inflammation and can disrupt the resolution of inflammation contributing to a devastating global cancer burden. While mechanisms of carcinogenesis have focused on genotoxic activity to induce mutations, nongenotoxic mechanisms such as inflammation and oxidative stress promote genotoxicity, proliferation, and mutations. Moreover, carcinogens initiate oxidative stress to synergize with inflammation and DNA damage to fuel a vicious feedback loop of cell death, tissue damage, and carcinogenesis. In contrast, stimulation of resolution of inflammation may prevent carcinogenesis by clearance of cellular debris via macrophage phagocytosis and inhibition of an eicosanoid/cytokine storm of pro-inflammatory mediators. Controlling the host inflammatory response and its resolution in carcinogen-induced cancers will be critical to reducing carcinogen-induced morbidity and mortality. Here we review the recent evidence that stimulation of resolution of inflammation, including pro-resolution lipid mediators and soluble epoxide hydrolase inhibitors, may be a new chemopreventive approach to prevent carcinogen-induced cancer that should be evaluated in humans.

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Section: Detection Of Carcinogensmentioning

confidence: 99%

Carcinogenesis: Failure of resolution of inflammation?

Fishbein

Hammock

Serhan

et al. 2021

Pharmacology & Therapeutics

138

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“…Thus, from an industrial point of view, it would be important to have a fast, portable and userfriendly device for the direct quantification of acrylamide in the last step of the elaboration of Californian-style black table olives, which only required a minimum sample pre-treatment. In this context, voltametric biosensors and aptasensors have been developed and applied for detecting acrylamide in foods and other matrices (Asnaashari, Esmaeilzadeh Kenari, Farahmandfar, Taghdisi, & Abnous, 2018;Asnaashari, Kenari, Farahmandfar, Abnous, & Taghdisi, 2019;Mülazimoğlu, Sağir, Durmuş, & Mülazimoğlu, 2017;Sani, Heng, Marugan, & Rajab, 2018;Wulandari, Ivandini, Irkham, Saepudin, & Einaga, 2019).…”

Section: Introductionmentioning

confidence: 99%

Assessing acrylamide content in sterilized Californian-style black table olives using HPLC-MS-QQQ and a potentiometric electronic tongue

Martín‐Vertedor

Rodrigues

Marx

et al. 2020

LWT

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The study aimed to evaluate the effects of olive cultivar (cvs. Manzanilla Cacereña and Hojiblanca) and the sterilization intensity/time-period (F 0 of 10-25 min at 121 ± 3°C) on the formation of acrylamide in table olives and brine. Olive cultivar and thermal sterilization had a significant impact on the amount of acrylamide produced (varying from 228 ± 94 to 286 ± 110 and 336 ± 126 to 373 ± 159 ng g −1 , for table olives and brine, respectively, determined by HPLC-MS-QQQ). Moreover, for both cultivars, linear positive relationships (0.931 ≤ R 2 ≤ 0.994) were found between the acrylamide concentration in olives and respective brine solutions, allowing to foresee a non-destructive indirect methodology for quantifying acrylamide in table olives. Finally, a potentiometric E-tongue was used to quantify acrylamide in both matrices. The lipid sensor membranes comprised on the sensor device showed potentiometric semi-logarithmic responses (0.962 ≤ R 2 ≤ 0.999) towards the acrylamide concentration for aqueous standard solutions, permitting the establishment of accurate multiple linear predictive models for the quantification of acrylamide in olives and brine solutions (repeated Kfold-CV: 0.97 ± 0.03 ≤ R 2 ≤ 0.99 ± 0.01; 12 ± 8 ≤ RMSE ≤ 28 ± 14 ng g −1) for both olive cultivars. Etongue could be used as non-destructive indirect detection method of acrylamide, based on the brine solution evaluation, and so, a complementary analytical tool to the conventional chromatographic analysis.

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“…The current signals for these compounds are similar with the current signal for cadmium (carcinogen). The carcinogen molecules occupied the binding spaces of the DNA and reduced the amount of methylene blue molecules that can bind to the bases of the DNA [47]. These results have shown that 1a , 1d , and 2b are classified as carcinogenic compounds.…”

Section: Resultsmentioning

confidence: 99%

“…This biosensor has been used for formaldehyde detection in mackerel fish extract and acrylamide determination in cassava chip extract. It has been compared with the standard Nash method, standard HPLC-UV method, and Ames test [47].…”

Section: Resultsmentioning

confidence: 99%

An Electrochemical DNA Biosensor for Carcinogenicity of Anticancer Compounds Based on Competition between Methylene Blue and Oligonucleotides

Sani¹,

Ariffin

Wong

et al. 2019

Sensors

Self Cite

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A toxicity electrochemical DNA biosensor has been constructed for the detection of carcinogens using 24 base guanine DNA rich single stranded DNA, and methylene blue (MB) as the electroactive indicator. This amine terminated ssDNA was immobilized onto silica nanospheres and deposited on gold nanoparticle modified carbon-paste screen printed electrodes (SPEs). The modified SPE was initially exposed to a carcinogen, followed by immersion in methylene blue for an optimized duration. The biosensor response was measured using differential pulse voltammetry. The performance of the biosensor was identified on several anti-cancer compounds. The toxicity DNA biosensor demonstrated a linear response range to the cadmium chloride from 0.0005 ppm to 0.01 ppm (R2 = 0.928) with a limit of detection at 0.0004 ppm. The biosensor also exhibited its versatility to screen the carcinogenicity of potential anti-cancer compounds.

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Electrochemical DNA biosensor for potential carcinogen detection in food sample

Cited by 31 publications

References 35 publications

Carcinogenesis: Failure of resolution of inflammation?

Carcinogenesis: Failure of resolution of inflammation?

Assessing acrylamide content in sterilized Californian-style black table olives using HPLC-MS-QQQ and a potentiometric electronic tongue

An Electrochemical DNA Biosensor for Carcinogenicity of Anticancer Compounds Based on Competition between Methylene Blue and Oligonucleotides

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