Electrochemical DNA sensing using osmium complexes as hybridization indicators

Pozo, Mayte; Alonso, C.; Pariente, F.; Lorenzo, Encarnación

doi:10.1016/j.bios.2004.08.002

Cited by 43 publications

(13 citation statements)

References 33 publications

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“…Besides direct oxidation of purine bases and electrocatalytic oxidation by redox indicators, e. g. ruthenium (100) and osmium complexes (101) have been showed. The oxidized mediator removes electrons from guanine in dsDNA, and after, the reduced mediator is oxidized at the electrode, returning to the oxidized state.…”

Section: New Electrochemical Approaches In Dna Biosensorsmentioning

confidence: 99%

Recent advances in nano-based electrochemical biosensors application in diagnosis and monitoring of diseases

Wc²,

Jm³

et al. 2011

Front Biosci

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Based on biological molecules combined with nanostructured components, the news generations of electrochemical biosensors can employ different transducers (potentiometric, amperometric and impedimetric) converting the chemical information into a measurable amperometric signal. Following this contemporary theme, our main focus in this review is to discuss different methodologies for application in biosensing, whose signal transduction is based on electrochemical principles. We apply a discussion on recent trends involving different nanostructured materials, but without daring to contemplate all nanomaterials incessantly cited in literature, which leads us to believe that this moment is an unprecedented revolution in the preparation of electrochemical biodevices. Besides, some structures of bio-nano interface and different electrochemical biosensors involved in diagnosis systems are also discussed. We outline in several parts of the report how nanoscience technologies are emerging in diagnostic medicine, as well as convergence of electrochemistry and bio-nanoscience. Our hopes for this review are that it can help different categories of researchers to understand the broad application area of electrochemistry and bioelectrochemistry, in order to detecting several types of diseases and biological phenomena.

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Section: New Electrochemical Approaches In Dna Biosensorsmentioning

confidence: 99%

Recent advances in nano-based electrochemical biosensors application in diagnosis and monitoring of diseases

Wc²,

Jm³

et al. 2011

Front Biosci

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“…Following hybridization with the complementary DNA sequence, the osmium complex was electrochemically accumulated within the double-stranded DNA layer. Electrochemical detection was performed by differential pulse voltammetry [197,198]. Gold electrodes modified by N,N’-bis (3,4-dihydroxybenzylidene)-1,2-diaminobenzene (3,4-DHS) and N,N ’-bis(2,5-dihydroxybenzylidene)-1,2-diamino-benzene (2,5-DHS) as electrochemical probes in DNA sensing have also been developed.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

State-of-the-Art of (Bio)Chemical Sensor Developments in Analytical Spanish Groups

Plata

Contento

Ríos

2010

Sensors

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(Bio)chemical sensors are one of the most exciting fields in analytical chemistry today. The development of these analytical devices simplifies and miniaturizes the whole analytical process. Although the initial expectation of the massive incorporation of sensors in routine analytical work has been truncated to some extent, in many other cases analytical methods based on sensor technology have solved important analytical problems. Many research groups are working in this field world-wide, reporting interesting results so far. Modestly, Spanish researchers have contributed to these recent developments. In this review, we summarize the more representative achievements carried out for these groups. They cover a wide variety of sensors, including optical, electrochemical, piezoelectric or electro-mechanical devices, used for laboratory or field analyses. The capabilities to be used in different applied areas are also critically discussed.

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“…Prior to immobilization, gold electrodes were polished and conditioned as previously described (Del Pozo et al, 2005b). The microscopic electrode areas were determined from the charge associated with gold oxide reduction in 0.1 M H 2 SO 4 .…”

Section: Immobilization Of Dna On Gold Electrodesmentioning

confidence: 99%

Comprehensive study of interactions between DNA and new electroactive Schiff base ligandsApplication to the detection of singly mismatched Helicobacter pylori sequences

Revenga-Parra

García

Lorenzo

et al. 2007

Biosensors and Bioelectronics

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Electrochemical DNA sensing using osmium complexes as hybridization indicators

Cited by 43 publications

References 33 publications

Recent advances in nano-based electrochemical biosensors application in diagnosis and monitoring of diseases

Recent advances in nano-based electrochemical biosensors application in diagnosis and monitoring of diseases

State-of-the-Art of (Bio)Chemical Sensor Developments in Analytical Spanish Groups

Comprehensive study of interactions between DNA and new electroactive Schiff base ligandsApplication to the detection of singly mismatched Helicobacter pylori sequences

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