Electrochemical enhancement of reactively sputtered rhodium, ruthenium, and iridium oxide thin films for neural modulation, sensing, and recording applications

Taylor, Gregory; Paladines, Rhandy; Marti, Anthony; Jacobs, D. C.; Tint, Saxon; Fones, Andrew; Hamilton, Hugh; Yu, Lei; Amini, Shahram; Hettinger, J. D.

doi:10.1016/j.electacta.2021.139118

Cited by 13 publications

(7 citation statements)

References 84 publications

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“…The electrochemical performance as measured by CV for all binary metal oxides improved with increased film thickness, and each voltammogram suggested the films were electrochemically stable. This characteristic is attributed to the morphology that results from the sputtering pressure conditions [35][36][37][38][39]. Generally, the slopes of the CSC C as a function of thickness for each binary metal oxide system were greater than that of their single metal oxide endmember.…”

Section: Discussionmentioning

confidence: 97%

Investigation of iridium, ruthenium, rhodium, and palladium binary metal oxide solid solution thin films for implantable neural interfacing applications

Taylor

Shallenberger

Tint

et al. 2021

Surface and Coatings Technology

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Section: Discussionmentioning

confidence: 97%

Investigation of iridium, ruthenium, rhodium, and palladium binary metal oxide solid solution thin films for implantable neural interfacing applications

Taylor

Shallenberger

Tint

et al. 2021

Surface and Coatings Technology

Self Cite

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“…Root mean square (RMS) height of the surface (S q ), and the surface area ratio (S dr ) were selected as two parameters that reflect “surface roughness” and “added surface area” also reported by Taylor et al . for similar neural interfacing applications 104 . Their mathematical formulation is provided in Eqs.…”

Section: Methodsmentioning

confidence: 99%

Femtosecond laser hierarchical surface restructuring for next generation neural interfacing electrodes and microelectrode arrays

Amini

Seche²,

May

et al. 2022

Sci Rep

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Long-term implantable neural interfacing devices are able to diagnose, monitor, and treat many cardiac, neurological, retinal and hearing disorders through nerve stimulation, as well as sensing and recording electrical signals to and from neural tissue. To improve specificity, functionality, and performance of these devices, the electrodes and microelectrode arrays—that are the basis of most emerging devices—must be further miniaturized and must possess exceptional electrochemical performance and charge exchange characteristics with neural tissue. In this report, we show for the first time that the electrochemical performance of femtosecond-laser hierarchically-restructured electrodes can be tuned to yield unprecedented performance values that significantly exceed those reported in the literature, e.g. charge storage capacity and specific capacitance were shown to have improved by two orders of magnitude and over 700-fold, respectively, compared to un-restructured electrodes. Additionally, correlation amongst laser parameters, electrochemical performance and surface parameters of the electrodes was established, and while performance metrics exhibit a relatively consistent increasing behavior with laser parameters, surface parameters tend to follow a less predictable trend negating a direct relationship between these surface parameters and performance. To answer the question of what drives such performance and tunability, and whether the widely adopted reasoning of increased surface area and roughening of the electrodes are the key contributors to the observed increase in performance, cross-sectional analysis of the electrodes using focused ion beam shows, for the first time, the existence of subsurface features that may have contributed to the observed electrochemical performance enhancements. This report is the first time that such performance enhancement and tunability are reported for femtosecond-laser hierarchically-restructured electrodes for neural interfacing applications.

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“…We benchmarked the activity and stability of the SIROF-based catalyst electrode against platinum electrode in 1X PBS electrolyte (pH=7.4). Linear sweep voltammetry (LSV) scan in anodic direction revealed the characteristic activation signal of iridium oxide in OER at approximately 1.6 V vs. RHE 34,35 . The SIROF catalyst demonstrated significantly lower overpotential of 395±18 mV compared to Pt electrode's 565±10 mV (Figure 1a) representing reduced energetic cost to produce oxygen with catalytic activity of SIROF.…”

Section: Effective Stable and Safe On-site Oxygen Deliverymentioning

confidence: 99%

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Lee,

Surendran,

Fleury

et al. 2023

Preprint

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Implantable cell therapies and tissue transplants require sufficient oxygen supply to function and are limited by a delay or lack of vascularization from the transplant host1,2. Exogenous oxygen production can support cells and tissues, such as pancreatic islets and engineered therapeutic cells. Previous oxygenation strategies have targeted gas circulation or decomposition of solid peroxides. These strategies however require bulky implants, transcutaneous supply lines, and are limited in their total oxygen production or regulation3,4. Readily integrated and controlled production of oxygen has eluded cell therapy devices. Here, we show an electrocatalytic approach that enables bioelectronic control of oxygen generation in complex cellular environments to sustain engineered cell viability and therapy production under hypoxic stress and at high cell densities. Nanostructured sputtered iridium oxide serves as an ideal catalyst for oxygen evolution reaction (OER) at neutral pH. It enables a lower OER onset and shows selective oxygen production without evolution of toxic side products over a 300 mV window of operation. This electrocatalytic on site oxygenator (ecO2) can sustain high cell loadings (>60k cells/mm3) in hypoxic conditions in vitro and in vivo. Our results demonstrate that exogenous oxygen production devices can be readily integrated into bioelectronic platforms and enable high cell loadings in smaller device footprints with broad applicability.

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Electrochemical enhancement of reactively sputtered rhodium, ruthenium, and iridium oxide thin films for neural modulation, sensing, and recording applications

Cited by 13 publications

References 84 publications

Investigation of iridium, ruthenium, rhodium, and palladium binary metal oxide solid solution thin films for implantable neural interfacing applications

Investigation of iridium, ruthenium, rhodium, and palladium binary metal oxide solid solution thin films for implantable neural interfacing applications

Femtosecond laser hierarchical surface restructuring for next generation neural interfacing electrodes and microelectrode arrays

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

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