Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure

Yoon, Jinho; Lee, Taek; Bharate, B.G.; Jo, Jinhee; Oh, Byung-Keun; Choi, Jeong‐Woo

doi:10.1016/j.bios.2016.11.064

Cited by 119 publications

(52 citation statements)

References 39 publications

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“…Regarding H 2 O 2 detection, the high‐sensitivity values of 3D flower‐like molybdenum disulfide (MoS 2 )/hemoglobin and hemoglobin‐mediated flower‐like Bi 2 Se 3 have been reported; although, they are limited by a high detection limit, narrow dynamic range, high response time (>10 s), and low biomolecule‐conjugation efficiency. Recently, MoS 2 ‐encapsulated graphene oxide was also reported by the authors regarding an amplification of the H 2 O 2 ‐detection process that is based on the redox behavior of the myoglobin . A more detailed comparison that is besides a number of the notable reported studies is also provided in Table S1 (Supporting Information).…”

Section: Introductionmentioning

confidence: 93%

“…Although, with major nanotechnology support, the TI properties have been boosted remarkably, but the direct utilization of the TIs into biotechnological applications is still challenging because of the difficulties regarding the surface functionalization and the necessity to increase their sensitivity and fidelity. Consequently, the encapsulation of these materials with other types of inorganic or organic materials seems demanding …”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells

Mohammadniaei

Yoon

Lee

et al. 2018

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A newly developed electrochemical biosensor composed of a topological insulator (TI) and metallic DNA (mDNA) is fabricated. The bismuth selenide nanoparticle (Bi Se NP) is synthesized and sandwiched between the gold electrode and another Au-deposited thin layer (Bi Se @Au). Then, eight-silver-ion mediated double-stranded DNA (mDNA) is immobilized onto the substrate (Bi Se @Au-mDNA) for the further detection of hydrogen peroxide. The Bi Se NP acts as the electrochemical-signal booster, while unprecedentedly its encapsulation by the Au thin layer keeps the TI surface states protected, improves its electrochemical-signal stability and provides an excellent platform for the subsequent covalent immobilization of the mDNA through Au-thiol interaction. Electrochemical results show that the fabricated biosensor represents much higher Ag redox current (≈10 times) than those electrodes prepared without Bi Se @Au. The characterization of the Bi Se @Au-mDNA film is confirmed by atomic force microscopy, scanning tunneling microscopy, and cyclic voltammetry. The proposed biosensor shows a dynamic range of 00.10 × 10 m to 27.30 × 10 m, very low detection limit (10 × 10 m), unique current response (1.6 s), sound H O recovery in serum, and substantial capability to classify two breast cancer subtypes (MCF-7 and MDA-MB-231) based on their difference in the H O generation, offering potential applications in the biomedicine and pharmacology fields.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells

Mohammadniaei

Yoon

Lee

et al. 2018

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“…9,10,21 Emerging evidence reports the applications of MoS 2 /GO nanocomposites in bioscience. [33][34][35] For instance, MoS 2 /GO nanocomposites revealed a greater antibacterial activity, 33 and enhanced selectivity and sensitivity in detecting glucose and hydrogen peroxide (H 2 O 2 ). 34,35 Other than these, no further studies on other applications and biocompatibility have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

et al. 2018

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Selective targeting plus optimal biocompatibility is still a big challenge in nanomedicine. Although many nanomaterials including graphene oxide (GO) and molybdenum disulfide (MoS 2 ) have been tested for this purpose, these materials possess both favorable features and drawbacks, which hampers their further development. Herein, we prepared MoS 2 /GO nanocomposites that manifested excellent dispersity in aqueous solutions and revealed acceptable biocompatibility in vitro and in vivo. Importantly, MoS 2 /GO displayed a novel feature to selectively target the lung. In other words, MoS 2 /GO manifested a pronounced tendency of localization towards the lung comparable to GO, offering a 'guided missile' effect in targeting the lung. Furthermore, MoS 2 /GO composites possessed enhanced drug loading capacity together with reinforced tumor-killing efficacy against cancer cells that have the propensity to metastasize to the lung. Importantly, MoS 2 /GO composites remarkably repressed metastatic tumor growth of B16 murine melanoma cancer cells in lungs of mice. Mechanistically, MoS 2 /GO was demonstrated to reveal compromised reactions towards macrophages at the nano-bio interface relative to GO, which is accountable for the interaction and the uptake of nanosheets by macrophages associated with phagocytosis and macrophagic activation. Considered together, our findings established new MoS 2 /GO nanocomposites with multi-functionalities including selective lung targeting, favorable drug loading capacity, elevated tumor killing efficacy and improved biocompatibility. Our study opens an avenue for MoS 2 /GO nanocomposites in cancer nanotheranostics.

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“…Molybdenum disulfide nanoparticles covered with myoglobin and encapsulated with graphene oxide was proposed for the first time as an electrochemical sensor for the detection of H 2 O 2 . The electrochemical investigations were performed using cyclic voltammetry and amperometric techniques . Graphene and single‐walled carbon nanotubes to load hemin were used to develop an amperometric biosensor to investigate the electrocatalytic activity of H 2 O 2 reduction.…”

Section: Sensors and Biosensorsmentioning

confidence: 99%

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

et al. 2019

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Graphene has attracted wide consideration in recent years to the assembly of sensitive sensors and biosensors due to its unique and remarkable physical and electrochemical properties. Moreover, graphene, as an essential two‐dimensional carbon material with remarkably high quartz and electronic superiority, has also received significant research attention. This review presents the different synthesis techniques of graphene; graphene functionalized based electrochemical sensors and biosensors for various health care appellations. Further, were discussed on the basis of enhanced catalytic activity, improved detection limit in conjunction with sensitivity, and selectivity. Synergistic action of graphene and metal oxide nanostructure has contributed towards high activity as a biosensing material. The results with different sensors and biosensors for the detection of significant biomarkers such as protein sensor, electrochemical immune sensor, phytochrome sensor, cholesterol biosensor glucose, hydrogen peroxide, and nicotinamide adenine dinucleotide detection sensor etc., and highlighted the use of graphene and functionalized graphene in different sensing platforms. Finally, the challenges related to less aggregated graphene‐based electrochemical sensors and biosensors as well as future research directions are discussed.

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Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure

Cited by 119 publications

References 39 publications

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

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Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure

Cited by 119 publications

References 39 publications

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi2Se3 Nanoparticles for the Detection of H2O2 Released from Breast Cancer Cells

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi2Se3 Nanoparticles for the Detection of H2O2 Released from Breast Cancer Cells

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

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Product

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Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells

Electrochemical Biosensor Composed of Silver Ion‐Mediated dsDNA on Au‐Encapsulated Bi₂Se₃ Nanoparticles for the Detection of H₂O₂ Released from Breast Cancer Cells