Electrochemical immunosensor with PVP/WS2 nanosheets electrode for fibroblast growth factor 21 detection based on metal organic framework nanozyme

Electrochemical protein biosensors for disease marker detection: progress and opportunities

“…Electrocatalysis was used to measure AD biomarkers in a competitive immunoassay using a magnetic bead platform with an LOD as low as 66 nM. Mitochondrial diseases are progressive incurable diseases and multisystem disorders with variable clinical presentations that are often difficult to diagnose 108 , 109 . Serum fibroblast growth factor-21 (FGF-21) is a new specific marker for mitochondrial disease and might facilitate diagnosis.…”

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

“…Zhongmei Chi received her BS degree (2016) in Chemistry at Liaoning Normal University and PhD degree (2021) in Analytical metal-organic frameworks (MOFs). [16][17][18] Various nanozymes have extremely broad application prospects in the fields of biosensing, immunoassay, and disease diagnosis. [19][20][21] Very recently, nanozyme-based sensors have been widely applied in electrochemical, [22][23][24] chemiluminescence, [25][26][27] luminescence, [28][29][30] and colorimetric [31][32][33] detection.…”

“…Thus far, great efforts have been devoted to developing various nanozymes, such as noble metals, 8,9 metal oxides, 10,11 metal sulfides/metal selenides, 12,13 carbon materials 14,15 and metal–organic frameworks (MOFs). 16–18 Various nanozymes have extremely broad application prospects in the fields of biosensing, immunoassay, and disease diagnosis. 19–21…”

Metal–organic frameworks on versatile substrates

“…115 Furthermore, different MOF crystals grown on electrodes and GCE substrates can also be found in these reports. 120–129…”

“…115 Furthermore, different MOF crystals grown on electrodes and GCE substrates can also be found in these reports. [120][121][122][123][124][125][126][127][128][129] 2.1.3 Carbon-based materials and polymer substrates. Carbon cloth (CC) is an ideal ber substrate due to its light weight, good conductivity, and excellent thermal properties, which have been reported in these studies.…”