Electrochemical investigation and determination of ceftazidime in pharmaceutical dosage forms and human urine

Tarınç, Derya; Dogan‐Topal, Burcu; Gölcü, Ayşegül; Özkan, Síbel A.

doi:10.1134/s1061934814090056

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Till date, this is the broadest linear calibration range for CFZ determination by electrochemical method. Detection limit and linear calibration of the proposed sensor together with previously published literature is tabulated in Table . From table 1 it is clear that the analytical performance of the prepared sensor is comparable with previously reported literature.…”

Section: Resultssupporting

confidence: 73%

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Pd@TTF Tailored Nanostructured Platform: Voltammetric Estimation of Ceftazidime

et al. 2017

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Herein, we report the synthesis of tetrathiafulvalene stabilized palladium nanocomposite (Pd@TTF) through one‐step simple chemical route without using any external reducing agent. Prepared Pd@TTF was further used for the electrochemical determination of ceftazidime (CFZ). A possible interaction mechanism has been proposed for the formation of palladium NPs sandwiched between TTF radical cations (Pd@TTF). As‐prepared Pd@TTF are characterized by using various techniques to investigate its structural, optical, and electrochemical properties The interaction of drug molecules with Pd@TTF is utilized in sensing of the drug using voltammetric techniques. The limit of detection (LOD) of CFZ is achieved up to 0.5 μM. The Pd@TTF modified sensor probe is successfully used for the determination of CFZ in the commercially available CFZ injection.

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Section: Resultssupporting

confidence: 73%

“…Detection limit and linear calibration of the proposed sensor together with previously published literature is tabulated in Table 1. [48][49][50][51][52][53][54] From table 1 it is clear that the analytical performance of the prepared sensor is comparable with previously reported literature.…”

Section: Microscopic Characterization and Elemental Analysissupporting

confidence: 74%

Pd@TTF Tailored Nanostructured Platform: Voltammetric Estimation of Ceftazidime

et al. 2017

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“…Side effects, bacterial resistant studies and proper dosage prescription, make it important to quantify the CFZ in food, biological media and pharmacy. [24][25][26] In a study graphene quantum dots has been used for determination of CFZ by Spectrofluorimetry method. 27 Although different analytical methods such as chromatography, 28,29 different kinds of spectroscopy, [30][31][32] and electrochemistry 24,26,33 Instruments.-Electrochemical and ECL experiments were performed at room temperature using a potentiostat/galvanostat combined with the ECL cell having photodiode detector (μStat ECL z E-mail: mandanaamiri@uma.ac.ir controlled with DropView 8400 software).…”

Section: Electrogeneratedmentioning

confidence: 99%

Electrochemiluminescence Sensor Based on N-Doped Carbon Quantum Dots for Determination of Ceftazidime in Real Samples

Afshary

Amiri

Bezaatpour

et al. 2022

J. Electrochem. Soc.

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We report an electrochemiluminescence (ECL) sensor based on nitrogen doped carbon quantum dots (N-CQDs), which has been synthesized by a solvothermal method. The N-CQDs were characterized using various techniques such as high-resolution transmission electron microscopy, field emission scanning electron microscopy, UV-Vis absorption and photoluminescence spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The potential sweep range (−0.5 to −2.2 V) shows a stable and strong ECL signal. Interestingly, the ECL intensity only decreased by less than 20% after storing at 4°C for 10 months. The applicability of the N-CQD sensor in electroanalytical chemistry was identified by the linear ECL on–off response for ceftazidime in a concentration range from 1×10-7 to 5×10-4 mol L–1 and a detection limit of 2.3×10-8 mol L–1. The results suggest that the proposed ECL sensor is robustly applicable for analysis of ceftazidime in real samples such as human serum, bovine milk, and commercial milk powder.

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“…Literature review showed that various analytical methods have been described for the estimation of CFZ including spectrophotometric [6][7][8][9][10][11][12][13][14], capillary electrophoresis [15][16][17][18], thin layer chromatography (TLC) [19][20][21], high performance liquid chromatography (HPLC) [22][23][24][25][26][27][28][29][30][31],electrochemical and voltammetric methods [32,33] have been reported for the estimation of CFZ in pure or in dosage forms. Pyridine is official in BP, EP [3,4] and United States Pharmacopeia (USP) [2] and is determined by high-performance liquid chromatography (HPLC) [34].…”

Section: Annals Of Reviews and Researchmentioning

confidence: 99%

Stability Indicating Rp-HPLC Method for Simultaneous Estimation of Ceftazidime Pentahydrate and its Impurity Product Pyridine in Powder Used for Making Solution in Vial for 1M & IV Injections

Mem¹

2018

ARR

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A new, sensitive, precise, simple, and stability indicating RP-HPLC method is developed and validated for simultaneous estimation of Ceftazidime pentahydrate(CFZ) and its impurity product Pyridine(PY) in powder which is used for making solution in vial for intramuscular (IM) & intravenous (IV) injections. The RP-HPLC method is performed on the Atlantis dc18 column (150 mm X 4.6 mm, 5μm particle size, using buffer solution of pH 7.0 containing 0.02 M anhydrous sodium acetate: acetonitrile (60:40 v/v) as the mobile phase at a flow rate of 1.5 mL/min, injection volume 20 µL and UV detection at 254 nm. The total run time is 5.0 min.Linear relationships are obtained in the ranges of 100-400 µg/ mL and 5-50µg/mL for CFZ and PY, respectively, with significantly different R t values of 1.456and 2.970min for the two studied drugs. Correlation coefficients (r) >0.9999, limits of detection 3.40 and 0.16 µg mL -1 and limits of quantitation of 10.33 and 0.49 µg mL -1 have been obtained for CFZ and PY, respectively. The suggested method is validated according to ICH guidelines. Hence it is suitable for laboratory control of starting materials, bulk and finished products.

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Electrochemical investigation and determination of ceftazidime in pharmaceutical dosage forms and human urine

Cited by 10 publications

References 19 publications

Pd@TTF Tailored Nanostructured Platform: Voltammetric Estimation of Ceftazidime

Pd@TTF Tailored Nanostructured Platform: Voltammetric Estimation of Ceftazidime

Electrochemiluminescence Sensor Based on N-Doped Carbon Quantum Dots for Determination of Ceftazidime in Real Samples

Stability Indicating Rp-HPLC Method for Simultaneous Estimation of Ceftazidime Pentahydrate and its Impurity Product Pyridine in Powder Used for Making Solution in Vial for 1M & IV Injections

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