Electrochemical investigations into host–guest interactions of a natural antioxidant compound with β-cyclodextrin

Ferreira, Fabricia da Rocha; Silva, Emanuella Gomes da; Leo, Lucila P. Méndez De; Calvo, Ernesto J.; Bento, Edson de Souza; Goulart, Marília Oliveira Fonseca; Abreu, Fabiane Caxico de

doi:10.1016/j.electacta.2010.09.066

Cited by 23 publications

(2 citation statements)

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“…Cyclodextrins (CDs) are cyclic oligosaccharides composed of several α-1,4-D-glucopyranose rings (Chen et al 2012). The cylindrical structure is composed of a hydrophilic exterior and an internal hydrophobic cavity (Ferreira et al 2010), a property that allows CDs to form inclusion complexes with organic molecules through host-guest interactions. The binding interactions within the CD-guest complex are most likely a summation of a variety of relatively weak forces such as Van der Waal forces, hydrophobic interactions and hydrogen bonding (Loftsson and Brewster 1996).…”

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confidence: 99%

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

2014

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The present study investigated five cyclodextrins (CDs) for the extraction of flavonols from apple pomace powder and optimized β-CD based extraction of total flavonols using response surface methodology. A 2(3) central composite design with β-CD concentration (0-5 g 100 mL(-1)), extraction temperature (20-72 °C), extraction time (6-48 h) and second-order quadratic model for the total flavonol yield (mg 100 g(-1) DM) was selected to generate the response surface curves. The optimal conditions obtained were: β-CD concentration, 2.8 g 100 mL(-1); extraction temperature, 45 °C and extraction time, 25.6 h that predicted the extraction of 166.6 mg total flavonols 100 g(-1) DM. The predicted amount was comparable to the experimental amount of 151.5 mg total flavonols 100 g(-1) DM obtained from optimal β-CD based parameters, thereby giving a low absolute error and adequacy of fitted model. In addition, the results from optimized extraction conditions showed values similar to those obtained through previously established solvent based sonication assisted flavonol extraction procedure. To the best of our knowledge, this is the first study to optimize aqueous β-CD based flavonol extraction which presents an environmentally safe method for value-addition to under-utilized bio resources.

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Section: Introductionmentioning

confidence: 99%

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

2014

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“…In GCE-CNT, it is possible to notice the increase in the current of the characteristic peaks of the LQM10, with displacement to more positive potential of Ep a1 and to potentials closer to 0V in the case of Ep a2 , after 50 consecutive sweeps, under the same conditions and with concentration of LQM10 in the constant medium(Figure 4(a)). Indicating the durability of the electrode and the facility of the oxidation process when modified with CNT[29].It was possible to construct a calibration curve for LQM10 in phosphate buffer of 0.2 mol/L, pH 7.02, using the GCE-CNT sensor, varying the concentration of LQM10 (10 −6 to 8 × 10 −6 mol/L) shown inFigure 4(b). With the anodic peak current, it was possible to determine constant stability or association by electrochemical experiments under these conditions (K F ), using the following equation (derived from the isotherm of Benesi-Hildebrand) (Equation…”

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Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Silva¹,

Oliveira²,

Candido³

et al. 2020

JBNB

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Aminoguanidine hydrazones (AGHs) are a class of compounds that have interesting pharmacological activities. They are derived from the same chemical group as aminoguanidine, so it has mixed properties (receptor and donor) in the formation of hydrogen bonds. Its anticancer agent properties were recently highlighted, but the molecules of this class have solubility in aqueous solutions that can be considered low. The identification of this class, by a simple, sensitive and low-cost technique, such as electrochemistry, which also allows the evaluation of its solubilization process through agents such as PAMAM dendrimer is the main objective of the work described here. The electrochemical response of the LQM10 (AGH derivative) was evaluated, as well as its behavior in different electrochemical sensors. Electrochemical experiments were performed in buffered (phosphate at pH 7.02 and acetate at 4.5). LQM10 has a reversible oxidation peak with a potential of +0.22 V. It was efficiently detected in different electrodes tested (glass carbon/CNT, glass carbon/CNT/PAMAM), which proves the viability of the electrodes for various analyses and has the determination of the apparent constant association, indicating its interaction with the analysis that is higher in the presence of the PAMAM encapsulating agent. This was corroborated by the results for the modified gold electrode with MUA and PAMAM. The sum of the results shows the possibility of electrochemically evaluating the Aminoguanidine hydrazone derivative, the viability of electrodes employed and the greater so-How to cite this paper:

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Subnanomolar electrochemical sensing of mangiferin using a polycationic organohalloysite as electrode modifier

Melataguia Tchieno,

Dmitrieva,

Pengou

2023

Electroanalysis

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Electrochemical investigations into host–guest interactions of a natural antioxidant compound with β-cyclodextrin

Cited by 23 publications

References 46 publications

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology

Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity: Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

Subnanomolar electrochemical sensing of mangiferin using a polycationic organohalloysite as electrode modifier

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