Electrochemical Methods Based on Molecularly Imprinted Polymers for Drug Detection. A Review

Adumitrăchioaie, Alina; Pharmacy, Pasteur St.

doi:10.20964/2018.03.75

Cited by 106 publications

(52 citation statements)

References 92 publications

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“…In a molecularly imprinted polymer, specific sites can be created for various templates such as amino acids [43], proteins [44,45,46], enzymes [47,48], hormones [49,50,51], antibodies [52,53,54], nucleic acids [55,56], bacteria [57], viruses [58,59,60], drugs [61,62], metal ions [63,64,65,66], toxins [67], antibiotics [68] and pesticides [69,70] and so on. Furthermore, MIPs are easy to synthesis, highly stable, cost-effective, and user-friendly.…”

Section: Molecular Imprinting Methodsmentioning

confidence: 99%

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Saylan

Akgönüllü

Yavuz

et al. 2019

Sensors

233

106

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Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

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Section: Molecular Imprinting Methodsmentioning

confidence: 99%

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Saylan

Akgönüllü

Yavuz

et al. 2019

Sensors

233

106

View full text Add to dashboard Cite

show abstract

“…Therefore, in affinity biosensor applications, MIPs are preferred increasingly [ 39 ]. There are also some drawbacks of MIPs; such as, leakage or incomplete removal of the template, random distribution of binding site, nonhomogenous morphology, and slow mass transfer [ 40 ].…”

Section: Affinity Biosensorsmentioning

confidence: 99%

Affinity biosensors developed with quantum dots in microfluidic systems

2021

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Quantum dots (QDs) are synthetic semiconductor nanocrystals with unique optical and electronic properties due to their size (2–10 nm) such as high molar absorption coefficient (10–100 times higher than organic dyes), resistance to chemical degradation, and unique optoelectronic properties due to quantum confinement (high quantum yield, emission color change with size). Compared to organic fluorophores, the narrower emission band and wider absorption bands of QDs offer great advantages in cell imaging and biosensor applications. The optoelectronic features of QDs have prompted their intensive use in bioanalytical, biophysical, and biomedical research. As the nanomaterials have been integrated into microfluidic systems, microfluidic technology has accelerated the adaptation of nanomaterials to clinical evaluation together with the advantages such as being more economical, more reproducible, and more susceptible to modification and integration with other technologies. Microfluidic systems serve an important role by being a platform in which QDs are integrated for biosensing applications. As we combine the advantages of QDs and microfluidic technology for biosensing technology, QD-based biosensor integrated with microfluidic systems can be used as an advanced and versatile diagnostic technology in case of pandemic. Specifically, there is an urgent necessity to have reliable and fast detection systems for COVID-19 virus. In this review, affinity-based biosensing mechanisms which are developed with QDs are examined in the domain of microfluidic approach. The combination of microfluidic technology and QD-based affinity biosensors are presented with examples in order to develop a better technological framework of diagnostic for COVID-19 virus.

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“…Different polymerization methods have been developed to prepare MIPs, such as bulk polymerization, suspension polymerization, precipitation polymerization, and polymerization on a solid surface. [5][6][7][8] Of all the methods developed to synthesize MIPs, one critical issue is to select the correct functional monomer, because the strength of the template-functional monomer interactions often determines the quality of the final imprinted sites. The template-functional monomer complex can be stabilized by various interactions including covalent bonding, hydrogen bond and metal ion coordination.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

Liu

Holdsworth

2020

Chirality

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We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors.

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Electrochemical Methods Based on Molecularly Imprinted Polymers for Drug Detection. A Review

Cited by 106 publications

References 92 publications

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Affinity biosensors developed with quantum dots in microfluidic systems

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

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