Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo

Flavin, Matthew T.; Paul, Marek A.; Lim, Alexander S.; Lissandrello, Charles; Ajemian, Robert; Lin, Samuel J.; Han, Jongyoon

doi:10.1073/pnas.2117764119

Cited by 8 publications

(9 citation statements)

References 51 publications

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“…Rapid advances in brain bioelectronics paved the way for several developed and experimental brain neuromodulation approaches. These neuromodulation devices use electrical, [ 30 ] electro‐mechanical, [ 31 ] optogenetic, [ 32 ] magnetic, [ 33 ] and ultrasonic approaches. [ 17a ] Current neuromodulators allow stimulation, inhibition, and sensing of various brain related activities.…”

Section: Self‐powered Brain Neuromodulationmentioning

confidence: 99%

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Elsanadidy

Mosa

Luo

et al. 2023

Adv Funct Materials

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Advances in implantable bioelectronics for the nervous system are reinventing the stimulation, inhibition, and sensing of neuronal activity. These efforts promise not just breakthrough treatments of several neurological and psychiatric conditions but also signal the beginning of a new era of computer‐controlled human therapeutics. Batteries remain the major power source for all implanted electrical neuromodulation devices, which impairs miniaturization and necessitates replacement surgery when the battery is drained. Triboelectric nanogenerators (TENGs) have recently emerged as an innovative power solution for self‐powered, closed loop electrical neurostimulation devices. TENGs can leverage the biomechanical activities of different body organs to sustainably generate electricity for electrical neurostimulation. This review features advances in TENGs as they pave the way for self‐sustainable closed loop neurostimulation. A comprehensive review of TENG research for the neurostimulation of brain, autonomic, and somatic nervous systems is provided. The direction of growth of this field, publication trends, and modes of TENG in implantable bioelectronics are also discussed. Finally, an insightful outlook into challenges facing self‐sustainable neuromodulators to reach clinical practice is provided, and solutions for neurological maladies are proposed.

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Section: Self‐powered Brain Neuromodulationmentioning

confidence: 99%

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Elsanadidy

Mosa

Luo

et al. 2023

Adv Funct Materials

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“…73 The same group recently transplanted this technique into a rat to show the enhancement of electrical stimulation selectivity to electrochemically modulated nerves. 74 Parameswaran et al modulated single primary neuron excitability by a photoelectrochemical approach. Coaxial silicon nanowires decorated by atomic gold were directly cast onto neurons.…”

Section: In Vivo Electrochemical Neuromodulationmentioning

confidence: 99%

“…Song et al depicted an early picture of activating and inhibiting neuromuscular signals via electrochemical polarization of ion concentrations with ion-selective membrane-modified nerve–electrode interfaces . The same group recently transplanted this technique into a rat to show the enhancement of electrical stimulation selectivity to electrochemically modulated nerves …”

Section: In Vivo Electrochemical Neuromodulationmentioning

confidence: 99%

New Opportunities of Electrochemistry for Monitoring, Modulating, and Mimicking the Brain Signals

Wu,

Yu,

Mao

2023

JACS Au

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In vivo electrochemistry is a powerful key for unlocking the chemical consequences in neural networks of the brain. The past half-century has witnessed the technology revolutionization in this field along with innovations in electrochemical concepts, principles, methods, and devices. Present applications of electrochemical approaches have extended from measuring neurochemical concentrations to modulating and mimicking brain signals. In this Perspective, newly reported strategies for tackling long-standing challenges of in vivo electrochemical brain monitoring (i.e., basal level measurement, electroactivity dependence, in vivo stability, neuron compatibility, multiplexity, and implantable device fabrication) are highlighted. Moreover, recent progress on neuromodulation tools and neuromorphic devices in electrochemical frameworks is introduced. A glimpse of future opportunities for electrochemistry in brain research is offered at last.

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“…Given the relatively large dimensions of these devices, the Poisson-Nernst-Planck (PNP) model [27] is a good candidate to capture both drift and diffusion transport mechanisms, as well as charge screening effects in the space-time domain. The PNP model can also be adapted to CPs [28], and has been employed in computational works focusing on the characterization and optimization of iontronic devices [29][30][31] or ISM-cuff electrodes [32]. Notwithstanding, to the extent of our knowledge, computational frameworks accounting for both ionic actuators and their effect on neuronal membranes are still missing in the literature.…”

Section: Introductionmentioning

confidence: 99%

Finite-element modeling of neuromodulation via controlled delivery of potassium ions using conductive polymer-coated microelectrodes

Verardo,

Mele,

Selmi

et al. 2024

J. Neural Eng.

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Objective. The controlled delivery of potassium is an interesting neuromodulation modality, being potassium ions involved in shaping neuron excitability, synaptic transmission, network synchronization, and playing a key role in pathological conditions like epilepsy and spreading depression. Despite many successful examples of pre-clinical devices able to influence the extracellular potassium concentration, computational frameworks capturing the corresponding impact on neuronal activity are still missing. Approach. We present a finite-element model describing a PEDOT:PSS-coated microelectrode (herein, simply ionic actuator) able to release potassium and thus modulate the activity of a cortical neuron in an in-vitro-like setting. The dynamics of ions in the ionic actuator, the neural membrane, and the cellular fluids are solved self-consistently. Main results. We showcase the capability of the model to describe on a physical basis the modulation of the intrinsic excitability of the cell and the synaptic transmission following the electro-ionic stimulation produced by the actuator. We consider three case studies for the ionic actuator with different levels of selectivity to potassium: ideal selectivity, no selectivity, and selectivity achieved by embedding ionophores in the polymer backbone. Significance. This work is the first step toward a comprehensive computational framework aimed to investigate novel neuromodulation devices targeting specific ionic species, as well as to optimize their design and performance, in terms of the induced modulation of neural activity.

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Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo

Cited by 8 publications

References 51 publications

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

New Opportunities of Electrochemistry for Monitoring, Modulating, and Mimicking the Brain Signals

Finite-element modeling of neuromodulation via controlled delivery of potassium ions using conductive polymer-coated microelectrodes

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