Electrochemical Monitoring of the Interaction between 4-Nonylphenol and DNA by Graphite and Carbon Nanotube Modified Graphite Electrodes

Karadeniz, Hakan; Caliskan, Ayfer; Uğuz, Cevdet

doi:10.2116/analsci.26.1065

Cited by 8 publications

(2 citation statements)

References 43 publications

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“…Uguz et al [13] reported that NP has an adverse effect on mitochondrial membrane potential. Furthermore, Karadeniz et al [14] have shown that NP causes oxidation of guanine base. This may suggest that NP can cause mutations in mitochondrial DNA (mtDNA), which lacks DNA repair mechanisms.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Nonylphenol on Hearing in Rats

Yücedağ¹,

Okur²,

Uğuz³

et al. 2014

Int Adv Otol

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OBJECTIVE:Nonylphenol is a neurotoxic substance widely present in the environment. Although its neurotoxic effects are well-known, to our knowledge, the ototoxic effects of nonylphenol on hearing have not been published in the literature yet. We aimed to investigate the effect of nonylphenol on hearing function in rats. MATERIALS and METHODS:Fifty rats were randomly divided into five Groups each containing 10 animals. Group 1 was a control Group and Group 2 was a solvent control containing ethanol alone, whereas Groups 3, 4, and 5 were treatment Groups exposed to the different concentrations of nonylphenol dissolved in ethanol for six-weeks. Distortion product otoacoustic emission measurements were evaluated at the end of exposure. RESULTS:In the distortion product otoacoustic emission measurement, signal-to-noise ratio values did not show any statistically significant differences between the control and ethanol Groups (p>0.05). But, we found significant differences between signal-to-noise ratio values of control and nonylphenol Groups at 4000 and 6000 Hz frequencies (p<0.05). Also, we found statistically significant difference between signal-to-noise ratio values of ethanol and nonylphenol Groups at 4000 and 6000 Hz frequencies (p<0.05). There was no statistically significant difference for signal-tonoise ratio values among nonylphenol Groups (Groups 3-5) (p>0.05). CONCLUSION:Our study showed that nonylphenol has negative effects on hearing function in rats but the effects do not seem to be dose-dependent. Further studies are needed to find whether nonylphenol has an effect on hearing loss in rats as well as hearing in human beings.

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Section: Discussionmentioning

confidence: 99%

The Effects of Nonylphenol on Hearing in Rats

Yücedağ¹,

Okur²,

Uğuz³

et al. 2014

Int Adv Otol

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“…There is also a report showing that NP may cause mutation in DNA by causing base oxidation, which leads to serious health problems. (Karadeniz et al ., ).…”

Section: Introductionmentioning

confidence: 97%

In vitroeffects of nonylphenol on motility, mitochondrial, acrosomal and chromatin integrity of ram and boar spermatozoa

et al. 2014

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The objective of this study was to determine the effects of nonylphenol (NP) on viability of ram and boar sperm in vitro. Ram or boar spermatozoa were exposed to 1, 10, 100, 250 and 500 μg NP ml(-1) for 1, 2, 3 or 4 h. Computer-assisted sperm motility analysis (CASA) system was used to evaluate sperm motility characteristics. Flow cytometry was used to determine mitochondrial membrane potential (MMP) and chromatin integrity, while epifluorescent microscopy was used to determine sperm acrosomal status. Exposure of both species spermatozoa to 250 and 500 μg NP ml(-1) was detrimental to progressive motility (P < 0.05), and its adverse effect was significant at lower (100 μg NP ml(-1) ) concentration (P < 0.05). The percentages of ram and boar spermatozoa with high MMP declined drastically after exposures to ≥250 μg ml(-1) NP (P < 0.05). Unlike chromatin integrity, which did not appear to be altered by NP exposure, there were dose-dependent NP effects (P < 0.05) on acrosomal integrity of both species at as low as 1 μg ml(-1) NP for boar spermatozoa and 10 μg ml(-1) NP for ram spermatozoa. These data show adverse effects of NP on ram and boar spermatozoa and thus its potential harmful effects on male reproduction as NP is found in fruits, vegetables, human milk, fish and livestock products.

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