The Effects of Nonylphenol on Hearing in Rats

Yücedağ, Fatih; Okur, Erdoğan; Uğuz, Cevdet; Zemheri, Fahriya; Kuzu, Selçuk; Ayçiçek, Abdullah; Kahveci, Orhan Kemal

doi:10.5152/iao.2014.017

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Laboratory studies on animals have demonstrated adverse effects of NP, such as on reproduction, development, neurotoxicity and inflammation ( Jie et al, 2013 ; Yücedağ et al., 2015 ). The responsibility of organisms are various by the exposing dose and duration, and the exposing time of life cycle ( Patisaul & Adewale, 2009 ; Solecki et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

Cha

Baek

et al. 2017

Dev Reprod

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ABSTRACT4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both F0 and F1. In females, NP decreased the weight of ovary and uterus in F0 but not in pre-pubertal F1 pubs. Fertility of male and female in F0 or F1 was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both F0 and F1. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in F0, but significantly decreased in NP 50 group of F1. The litter size and sex ratios of offspring in F1 and F2 were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of F0 and F1 but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.

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Section: Discussionmentioning

confidence: 99%

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

Cha

Baek

et al. 2017

Dev Reprod

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“…NF'nin erkek üremesini etkilediği ve pankreas da dahil olmak üzere çeşitli organlara zararlı olduğunu gösteren kanıtlar da mevcuttur [12]. Yücedağ ve ark.,'nın [13] yaptığı diğer bir çalışmada sıçanlarda NF'nin işitme fonksiyonu üzerinde olumsuz etkilere sahip olduğu gösterilmiştir. Ergün ve ark., [14]'nın yaptığı diğer bir 73 çalışmada; NF ve BFA'nın çevresel dozlarının (0,001; 0,1; 1, 10 ve 100 µg NF/ml ve 0,001; 0,1; 1, 10 ve 100 µg BFA/ ml) sığırlarda sperm DNA'sına ve oosit olgunlaşmasına etkileri belirlenmiştir.…”

Section: Nonilfenol 'üN Genel öZellikleriunclassified

Endocrine Disruptive Chemicals: Nonylphenol and Bisphenol A

Zemheri

Uğuz

2018

Marmara Fen Bilimleri Dergisi

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ÖzTeknoloji ve bilimin ilerlemesi, insan hayatını önemli ölçüde kolaylaştırmış ancak çeşitli olumsuzlukları da beraberinde getirmiştir. Çevrede mevcut olan kimyasallar canlılığı olumsuz yönde etkilemektedir. Bu maddeler gıda katkı maddeleri, kozmetik ve ilaç sanayide kullanılan kimyasallar, pestisitler, herbisitler, sigara dumanı ve alkoller gibi bileşiklerdir. Kirleticilerin canlıların sağlığı üzerindeki olası olumsuz etkileri giderek artmakta özellikle de canlıların endokrin sistemini etkilemektedir. Endokrin bozucu kimyasalların başında çoğu endüstride kullanılan nonilfenol (NF) ve bisfenol A (BFA) gibi bileşikler yer almaktadır. Genelde parçalanabilir olan bu maddeler arıtma tesislerinde uzaklaştırılabilmelerine rağmen, indirgenmiş konsantrasyonlarda atık sularla nehir ve çaylara (akarsulara) verilmektedir. Bu şekilde de biyolojik döngüye katılarak biyokütle tarafından depolanmaktadır. Ksenoöstrojenik olarak adlandırılan bu kimyasallar, endüstride ve evlerdeki çeşitli kullanımları yanında, deterjan, sabun ve temizlik maddelerinin ana bileşeni olarak da büyük önem taşımaktadır. Bu kimyasalların çoğu veya bunların parçalanma ürünleri mutajenik, östrojenik, toksik veya karsinojenik olabilmektedir. Ayrıca üreme ve gelişmede görev yapan östrojen, progesteron, androjen ve diğer hormonların metabolik faaliyetlerini, hormon reseptör bölgelerine bağlanarak hormon gibi davranarak veya doğal hormonun spesifik reseptör bölgesine bağlanmasını engelleyerek anti-hormonal etki gösterebildiğinden, endişelerin ortaya çıkmasına neden olmaktadır. Bu nedenle NF ve BFA'nın olası dolaylı veya direkt etkilerinin moleküler düzeyde incelenmesi önem arz etmekte ve önemli araştırma konuları arasında olduğu öngörülmektedir.Anahtar kelimeler: Endokrin bozucu kimyasallar, Nonilfenol, Bisfenol A, çevre, gen AbstractThe improvement of technology and science has facilitated human, but these brought various negative effects. The chemicals that exist in the environment affects the vitality negatively. These compounds are such as food additives, cosmetics and medicines used in industry, pesticides, herbicides, cigarette smoke and alcohols. The possible negative effects of pollutants on the health of living beings are increasing. These especially affect the endocrine system of living things. Endocrine disrupting chemical compounds are nonylphenol (NP) and bisphenol A (BPA) which are most commonly used in the industry. These degradable materials are removed at the treatment facility, but reduced concentrations of them are given to rivers and streams. In this way, they participate in the biological cycle and stored by the biomass. These chemicals are called xenoestrogens, and they have various usage at home and industry. In addition to these, they have great importance as the main component of detergents, soaps and cleaners. Most of them or their decomposition products may be mutagenic, estrogenic, toxic or carcinogenic. In addition, they could block the metabolic activities of estrogen, progesterone, androgen and other hormones by means of adherin...

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“…

Dear Editor, I read with great interest the recent study by Yücedağ et al [1] entitled "The Effects of Nonylphenol on Hearing in Rats." It needs to be specified in the article if the hearing levels of the rats were evaluated before the study or not.

Another point I would like to emphasize is that the hearing levels of the rats after the application of ethanol and nonylphenol were evaluated by distortion product otoacoustic emission (DPOAE).

…”

mentioning

confidence: 99%

“…Dear Editor, I read with great interest the recent study by Yücedağ et al [1] entitled "The Effects of Nonylphenol on Hearing in Rats." It needs to be specified in the article if the hearing levels of the rats were evaluated before the study or not.…”

mentioning

confidence: 99%

Letter to the Editor regarding article by Yücedag et al. “The Effects of Nonylphenol on Hearing in Rats”

Kılıç

2015

Int Adv Otol

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Dear Editor, I read with great interest the recent study by Yücedağ et al. [1] entitled "The Effects of Nonylphenol on Hearing in Rats." It needs to be specified in the article if the hearing levels of the rats were evaluated before the study or not.Another point I would like to emphasize is that the hearing levels of the rats after the application of ethanol and nonylphenol were evaluated by distortion product otoacoustic emission (DPOAE). Recent studies suggest that otoacoustic emissions are produced by the electromobility of the outer hair cells (OHCs); however, retrocochlear and sensory pathologies caused by inner hair cell (IHC) damage do not produce DPOAE [2][3][4][5][6]. There are some drugs that cause severe IHC loss without OHC damage and cochlear nerve loss in the absence of hair cell loss [7][8][9][10][11][12][13] . There are no other studies demonstrating the otologic effects of nonylphenol. The effects of nonylphenol on hair cells and the cochlear nerve are unclear. IHC damage and retrocochlear pathologies cannot be evaluated by DPOAE; therefore, the hearing levels of the rats should have been evaluated by auditory brainstem response instead of DPOAE.Peer-review: Externally peer-reviewed.

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The Effects of Nonylphenol on Hearing in Rats

Cited by 5 publications

References 23 publications

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

Endocrine Disruptive Chemicals: Nonylphenol and Bisphenol A

Letter to the Editor regarding article by Yücedag et al. “The Effects of Nonylphenol on Hearing in Rats”

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