Electrochemical platinum coatings for improving performance of implantable microelectrode arrays

Haro, Carmen de; Mas, Roser; Abadal, G.; Muñoz, Javier; Pérez‐Murano, F.; Domı́nguez, Carlos

doi:10.1016/s0142-9612(02)00195-3

Cited by 45 publications

(30 citation statements)

References 8 publications

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“…The surface of sputtered platinum is very smooth (R a < 1 nm) making its effective surface area nearly same as its geometrical dimensions. In order to develop higher resolution microelectrodes with a much smaller geometrical surface area, one effective way to decrease the impedance is to use Pt electroplating (de Haro et al, 2002) i.e. the fabrication of sponge-like Pt surfaces with much higher roughness and surface areas.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Myllymaa

Korhonen

et al. 2009

Biosensors and Bioelectronics

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Section: Discussionmentioning

confidence: 99%

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Myllymaa

Korhonen

et al. 2009

Biosensors and Bioelectronics

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“…The sputtered thin-film Pt electrodes have smooth surfaces and relatively higher impedance. For long-term applications requiring electrical stimulation these thin-film microelectrodes could be platinized to increase thickness and surface roughness while simultaneously decreasing impedance (de Haro et al, 2002), or iridium oxide films could be electrodeposited onto the microfabricated Pt electrodes (Ges et al, 2005). …”

Section: Microfabricationmentioning

confidence: 99%

Flexible polyimide microelectrode array for in vivo recordings and current source density analysis

Cheung

Renaud

Tanila

et al. 2007

Biosensors and Bioelectronics

213

142

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This work presents implantable, flexible polymer-based probes with embedded microelectrodes for acute and chronic neural recordings in vivo, as tested on rodents. Acute recordings using this array were done in mice under urethane anesthesia and compared to those made using siliconbased probes manufactured at the Center for Neural Communication Technology, University of Michigan. The two electrode arrays yielded similar results. Recordings with chronically implanted polymer-based electrodes were performed for 60 days post-surgically in awake, behaving rats. The microelectrodes were used to monitor local field potentials and capture laminar differences in function of cortex and hippocampus, and produced response waveforms of undiminished amplitude and signal-to-noise ratios 8 weeks after chronic implantation. The polymer-based electrodes could also be connected to a lesion current to mark specific locations in the tissue. Current source density (CSD) analysis from the recordings depicted a source-sink-composition. Tissue response was assessed 8 weeks after insertion by immunochemical labeling with glial fibrillary acidic protein (GFAP) to identify astrocytes, and histological analysis showed minimal tissue reaction to the implanted structures.

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“…In this respect, the studies discussed here were aimed at demonstrating that UNCD is a much more suitable material than silicon for fabrication of bioMEMS, since silicon cannot survive long term implantation into several organs of the human body, such as in the case of a Si microchip implantable in the eye, as the main component of an artificial retina to restore sight to people blinded by retina degeneration, where it is being demonstrated that UNCD bioinert encapsulation coating will be the enabler of the Si microchip implantation in the eye (Xiao et al 2006) or as in the case of prosthesis such as artificial joints, where a high wear resistant coating like UNCD should provide also good cell adhesion to enhance fixation of the prosthesis in the bone. On the other hand, the comparison of UNCD with Platinum (Pt), as a biomaterial, was also targeted because Pt is a noble metal that has been extensively used for applications in microelectrodes for monitoring neural activity and for immunosensors for the brain (de Haro et al 2002). For all the bio related applications discussed above, it is essential that cells have an affinity for the surface of the implanted device.…”

Section: Introductionmentioning

confidence: 99%

Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications

Bajaj

Akin

Gupta

et al. 2007

Biomed Microdevices

113

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Surfaces of materials that promote cell adhesion, proliferation, and growth are critical for new generation of implantable biomedical devices. These films should be able to coat complex geometrical shapes very conformally, with smooth surfaces to produce hermetic bioinert protective coatings, or to provide surfaces for cell grafting through appropriate functionalization. Upon performing a survey of desirable properties such as chemical inertness, low friction coefficient, high wear resistance, and a high Young's modulus, diamond films emerge as very attractive candidates for coatings for biomedical devices. A promising novel material is ultrananocrystalline diamond (UNCD ® ) in thin film form, since UNCD possesses the desirable properties of diamond and can be deposited as a very smooth, conformal coating using chemical vapor deposition. In this paper, we compared cell adhesion, proliferation, and growth on UNCD films, silicon, and platinum films substrates using different cell lines. Our results showed that UNCD films exhibited superior characteristics including cell number, total cell area, and cell spreading. The results could be attributed to the nanostructured nature or a combination of nanostructure/surface chemistry of UNCD, which provides a high surface energy, hence promoting adhesion between the receptors on the cell surface and the UNCD films.

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Electrochemical platinum coatings for improving performance of implantable microelectrode arrays

Cited by 45 publications

References 8 publications

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Flexible polyimide microelectrode array for in vivo recordings and current source density analysis

Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications

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