Electrochemical probe for the monitoring of DNA–protein interactions

Syntheses and in vitro antitumor activities of ferrocene-conjugated Arg-Gly-Asp peptides

“…However, the attachment of fluorescent markers may affect the delivery and specific targeting of drugs, and the radiolabel always leads to serious side effects to normal cells [24,26,34,35]. In contrast, electrochemical probes have been reported to directly detect the interactions in biological process [36], which can provide good sensitivity and simplicity of use. The probe can be readily formed by attachment of electroactive groups to the biologically important substances.…”

Interaction of sulfadiazine with DNA on a MWCNT modified glassy carbon electrode: Determination of DNA

“…Under the optimum conditions, the possible interferences of several ions such as NH 4 + , Li + , Al 3+ , Ca 2+ , Cd 2+ , Cu 2+ , CO 3 2− , Sn 2+ , Na + , K + , Ni 2+ , Fe 2+ , Zn 2+ , Ba 2+ , Sr 2+ , Pb 2+ , Cr 2+ , Cl − , SO 4 2− , NO 3 − , HSO 4 − , HPO 4 2− were investigated by premixing DNA with the foreign substances. Amino acids such as, l-lysine, l-arginine, l-serine, l-histidine, l-glutamic acid, l-threonine and urea were investigated but did not show any interference effect.…”

“…Moreover, nucleic acids interaction with drugs is a fundamental issue in life phenomena. This process is associated with molecular recognition in DNA hybridization, gene mutations, sensing of bioactive agents such as anticancer drugs, and action mechanism of some DNA-targeted drugs [4][5][6].…”

A microfluidic electrochemical sensor array for characterizing protein interactions with various surface chemistries

“…Most often, these interactions involve affinity based binding involving antibodies, DNA and proteins [1][2]. Detection of particular proteins is an important issue for the drug screening community and has been a source of motivation for many recently reported biosensors [3][4][5]. The challenge with many of these biosensors is achieving an acceptable level of selectivity.…”