Electrochemical Reduction of Benzaldehyde as its Girard-P Derivative at the Mercury Electrode and Differential-Pulse Polarographic Determination of Benzaldehyde

López, Luís J. Moreno; Mochón, M. Callejón; Sánchez, Joaquín Fernández; Bello‐López, Miguel Ángel; Pérez, A. Guiraúm

doi:10.1007/s006040170022

Cited by 5 publications

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“…Over the past years, there are numerous analytical reports toward the detection of aldehyde compounds and their derivatives. Conventionally, these compounds have been analyzed by gas chromatography (GC), − high-performance liquid chromatography (HPLC), − mass spectrometry (MS), and electrochemical techniques. , These methods, nonetheless, exhibit high sensitivity and selectivity as well as precise and accurate determination. They still involve plenty of unavoidable limitations; for instance, they are time-consuming, have a complicated sample preparation, and require skillful experts.…”

Section: Introductionmentioning

confidence: 99%

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Jongkhumkrong

Thaveesangsakulthai

Sukbangnop

et al. 2022

ACS Appl. Mater. Interfaces

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Over the past years, lung cancer has been one of the vital cancer-related mortalities worldwide and has inevitably exhibited the highest death rate with the subsequent need for facile and convenient diagnosis approaches to identify the severity of cancer. Previous research has reported long-chain aldehyde compounds such as hexanal, heptanal, octanal, and nonanal as potential biomarkers of lung cancer. Herein, the helicene dyeencapsulated ethyl cellulose (EC@dye-NH) nanosensors have been applied for the potentially sensitive and specific detection of longchain aldehydes in aqueous media. The sensors contain the intrinsic hydrazide group of dye-NH, which is capable of reacting an aldehyde group via imine formation and the EC backbone. This offers the synergistic forces of hydrophobic interactions with alkyl long-chain aldehydes, which could induce self-assembly encapsulation of EC@dye-NH nanosensors and strong fluorescence responses. The addition of long-chain aldehyde would induce the complete micellar-like nanoparticle formation within 15 min in acetate buffer pH 5.0. The limit of detection (LOD) values of EC@dye-NH nanosensors toward heptanal, octanal, and nonanal were 40, 100, and 10 μM, respectively, without interference from the lung fluid matrices and short-chain aldehydes. For practical applicability, this sensing platform was developed for quantification of the long-chain aldehydes in lung fluid samples with 98−101% recoveries. This EC@ dye-NH nanosensor was applied to quantify nonanal contents in lung fluid samples. The results of this method based on EC@dye-NH nanosensors were then validated using standard gas chromatography−mass spectrometry (GC-MS), which gave results consistent with the proposed method. With intracellular imaging application, the EC@dye-NH nanosensors demonstrated excellent intracellular uptake and strong green fluorescence emission upon introducing the nonanal into the lung cancer cells (A549). Thus, the developed nanosensing approach served as the potential fluorescent probes in medical and biological fields, especially for lung cancer disease diagnosis based on highly selective and sensitive detection of long-chain aldehydes.

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Section: Introductionmentioning

confidence: 99%

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Jongkhumkrong

Thaveesangsakulthai

Sukbangnop

et al. 2022

ACS Appl. Mater. Interfaces

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Development of a benzaldehyde sensor utilizing chemiluminescence on nanosized Y₂O₃

Zhang

Wang

et al. 2008

Luminescence

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A chemiluminescence sensor has been proposed for sensitive determination of benzaldehyde, with nanosized Y(2)O(3) as the sensing material. Under optimized conditions, the linear range of the CL intensity vs. the concentration of benzaldehyde vapour is 1.8 ng/mL-10.8 microg/mL (r(2) = 0.9996), with a detection limit of 0.90 ng/mL (signal:noise ratio = 3:1). The sensor also exhibits high selectivity to benzaldehyde because no or weak CL signals have been detected when foreign substances are introduced into the sensor. In addition, the sensor also shows good stability and longer lifetime within 100 h. The results indicate that the proposed sensor, which has high sensitivity and selectivity, shows great potential for the detection of benzaldehyde.

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Enhanced sensitivity of self-assembled-monolayer-based SPR immunosensor for detection of benzaldehyde using a single-step multi-sandwich immunoassay

et al. 2007

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This paper describes the fabrication and sensing characteristics of a self-assembled monolayer (SAM)-based surface plasmon resonance (SPR) immunosensor for detection of benzaldehyde (BZ). The functional sensing surface was fabricated by the immobilization of a benzaldehyde-ovalbumin conjugate (BZ-OVA) on Au-thiolate SAMs containing carboxyl end groups. Covalent binding of BZ-OVA on SAM was found to be dependent on the composition of the base SAM, and it is improved very much with the use of a mixed monolayer strategy. Based on SPR angle measurements, the functional sensor surface is established as a compact monolayer of BZ-OVA bound on the mixed SAM. The BZ-OVA-bound sensor surface undergoes immunoaffinity binding with anti-benzaldehyde antibody (BZ-Ab) selectively. An indirect inhibition immunoassay principle has been applied, in which analyte benzaldehyde solution was incubated with an optimal concentration of BZ-Ab for 5 min and injected over the sensor chip. Analyte benzaldehyde undergoes immunoreaction with BZ-Ab and makes it inactive for binding to BZ-OVA on the sensor chip. As a result, the SPR angle response decreases with an increase in the concentration of benzaldehyde. The fabricated immunosensor demonstrates a low detection limit (LDL) of 50 ppt (pg mL(-1)) with a response time of 5 min. Antibodies bound to the sensor chip during an immunoassay could be detached by a brief exposure to acidic pepsin. With this surface regeneration, reusability of the same sensor chip for as many as 30 determination cycles has been established. Sensitivity has been enhanced further with the application of an additional single-step multi-sandwich immunoassay step, in which the BZ-Ab bound to the sensor chip was treated with a mixture of biotin-labeled secondary antibody, streptavidin and biotin-bovine serum albumin (Bio-BSA) conjugate. With this approach, the SPR sensor signal increased by ca. 12 times and the low detection limit improved to 5 ppt with a total response time of no more than ca. 10 min. Figure A single-step multi-sandwich immunoassay step increases SPR sensor signal by ca. 12 times affording a low detection limit for benzaldehyde of 5 ppt.

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Electrochemical Reduction of Benzaldehyde as its Girard-P Derivative at the Mercury Electrode and Differential-Pulse Polarographic Determination of Benzaldehyde

Cited by 5 publications

References 1 publication

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Development of a benzaldehyde sensor utilizing chemiluminescence on nanosized Y₂O₃

Enhanced sensitivity of self-assembled-monolayer-based SPR immunosensor for detection of benzaldehyde using a single-step multi-sandwich immunoassay

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Electrochemical Reduction of Benzaldehyde as its Girard-P Derivative at the Mercury Electrode and Differential-Pulse Polarographic Determination of Benzaldehyde

Cited by 5 publications

References 1 publication

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Helicene-Hydrazide Encapsulated Ethyl Cellulose as a Potential Fluorescence Sensor for Highly Specific Detection of Nonanal in Aqueous Solutions and a Proof-of-Concept Clinical Study in Lung Fluid

Development of a benzaldehyde sensor utilizing chemiluminescence on nanosized Y2O3

Enhanced sensitivity of self-assembled-monolayer-based SPR immunosensor for detection of benzaldehyde using a single-step multi-sandwich immunoassay

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Development of a benzaldehyde sensor utilizing chemiluminescence on nanosized Y₂O₃