Electrochemical sensing of mesalazine and its N-acetylated metabolite in biological samples using functionalized carbon nanotubes

Two-Dimensional Copper Tungstate Nanosheets: Application toward the Electrochemical Detection of Mesalazine

“…3−5 However, MSA is an aminosalicylate drug that acts locally in the gut and has its major actions, which can cause several health problems. 6,7 Therefore, accurate determination of MSA in clinical and pharmacological aspects is a very important task. In recent years, several analytical techniques have been investigated and developed including high-performance liquid chromatography, UV spectrophotometry, colorimetry, fluorescence sensors, electrochemical sensors, capillary electrophoresis, and mass spectrometry.…”

“…In respect to IBD treatment, MSA exhibits good performance and provides protection against the growth of colorectal cancer cells . Likewise, the significant merits are involved in using MSA such as inhibiting bacterial peptides and inhibits cell injury in the inflamed mucosa by trapping the reactive oxygen species, thereby, greatly reducing their toxicity. − However, MSA is an aminosalicylate drug that acts locally in the gut and has its major actions, which can cause several health problems. , Therefore, accurate determination of MSA in clinical and pharmacological aspects is a very important task. In recent years, several analytical techniques have been investigated and developed including high-performance liquid chromatography, UV spectrophotometry, colorimetry, fluorescence sensors, electrochemical sensors, capillary electrophoresis, and mass spectrometry. − Among these, electrochemical methods could provide low cost, facile operation, rapid response, and good selectivity and sensitivity. − Detection of MSA in a bare GC electrode is not possible due to the high detection limit, low sensitivity, and small linear range.…”

Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

“…This is especially noteworthy in the pharmaceutical, and medical industries in the sensing of molecules, such as the anti-HIV drug zidovudine, 84 the anxiolytic buspirone hydrochloride, 294 the neuroleptic promethazine, 295 the anticancer drug 5-fluorouracil, 296 paracetamol, 297 levodopa, 298 and the selective serotonin receptor agonist zolmitriptan among many others. 94 Additionally, these biosensors have been used in the detection of multiple biologically relevant molecules such as the ascorbate anion, 299 mesalazine, 300 fluvoxamine, 301 carbohydrates, 302 the hazardous pollutants amitrole, 85 and bisphenol A, 87,303 xanthine, 304 17αethinylestradiol, 305 as well as the neurotransmitters serotonin 306,307 and epinephrine. 308 Zidovudine is an anti-retroviral drug used in the treatment of HIV; however, zidovudine is very toxic, and as such, its detection and determination in human serum is of critical importance.…”

Construction of a ratio fluorescence assay of 5-aminosalicylic acid based on its aggregation induced emission with blue emitting N/P-codoped carbon dots

“…So, decorated release agents are designed for drug delivery at the terminal ileum and colon. 5 At present, the generally recognized methods for studying the structure and performance of 5-ASA include spectrophotometry, 6,7 high-performance liquid chromatographic, 8 electronic chemistry 3 and liquid chromatography-mass spectrometry, 9,10 etc. However, there is a little means for the detection of 5-ASA in drug and biological samples, due to the complexity of 5-ASA derivatization process, cumbersome extraction process and expensive instruments, and low detection capacity.…”