Electrochemical sensor for cancer cell detection using calix[8]arene/polydopamine/phosphorene nanocomposite based on host−guest recognition

Xu, Hanbin; Zheng, Jing; Liang, Huan; Li, Can-Peng

doi:10.1016/j.snb.2020.128193

Cited by 29 publications

(12 citation statements)

References 39 publications

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“…This value is comparable with those obtained in previous works (Table S2†). 23,26,43–45 Indeed, PDA has been reported to be a suitable material to develop electrochemical cytosensor for detection of A-549 due to the strong adhesion between PDA and receptor-rich tumor cells. 23 Also, the detection limit was improved by fourteen times compared with sensing platform without AuNPs/rGO ad-layer (Fig S5†).…”

Section: Resultsmentioning

confidence: 99%

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Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells

et al. 2023

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Section: Resultsmentioning

confidence: 99%

“…This value is comparable with those obtained in previous works (Table S2 †). 23,26,[43][44][45] Indeed, PDA has been reported to be a suitable material to develop electrochemical cytosensor for detection of A-549 due to the strong adhesion between PDA and receptor-rich tumor cells. 23…”

Section: Cell Detectionmentioning

confidence: 99%

Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells

et al. 2023

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“…Recently, a ratiometric cytosensor has been established with Fe 3 O 4 @SiO 2 @Au nanoparticles coupled to a DNA walker and a surface-enhanced Raman spectroscopy tag (Au nanoparticles labeled with DNA and Raman molecules), resulting in a detection limit as low as one cell 56 . Compared to the previous reports 40,[57][58][59] , our biosensing platform has the great advantage of being developed with no need for a complex instrument, time-consuming multiple steps, or labeling while offering remarkable sensitivity. The selectivity of the biosensing platform was analyzed by the DPV current of MCF-7 cells (target cells), and low/negative-level folate expressed cells including SKBR-3, A549, and Saso-2.…”

Section: Characterization Of the Zc-based Biosensing Platformmentioning

confidence: 99%

Facile preparation of a cost-effective platform based on ZnFe2O4 nanomaterials for electrochemical cell detection

Vajhadin

Mazloum‐Ardakani

Hemati

et al. 2023

Sci Rep

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Circulating tumor cells (CTCs) are important tumor markers that indicate early metastasis, tumor recurrence, and treatment efficacy. To identify and separate these cells from the blood, new nanomaterials need to be developed. The present study explored the potential application of ZnFe2O4 magnetic nanoparticles in capturing CTCs with cell surface markers. Folic acid was coupled to l-cysteine-capped ZnFe2O4 nanoparticles (ZC) to provide binding sites on ZnFe2O4 nanoparticles for the recognition of folate bioreceptors, which are highly expressed in MCF-7 breast cancer cells. The cytotoxicity of ZnFe2O4 nanoparticles and ZC against MCF-7 was analyzed with the MTT assay. After 24 h of incubation, there were IC50 values of 702.6 and 805.5 µg/mL for ZnFe2O4 and ZC, respectively. However, after 48 h of incubation, IC50 values of ZnFe2O4 and ZC were reduced to 267.3 and 389.7 µg/mL, respectively. The cell quantification was conducted with magnetically collected cells placed on a glassy carbon electrode, and the differential pulse voltammetry (DPV) responses were analyzed. This cost-effective ZnFe2O4-based biosensing platform allowed cancer cell detection with a limit of detection of 3 cells/mL, ranging from 25 to 104 cells/mL. In future, these functionalized zinc ferrites may be used in electrochemical cell detection and targeted cancer therapy.

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“…The rich chemistries of PDA allow the facile and diverse secondary modifications of flexible bioelectronics with functional moieties on raw substrate. The functional moieties include L-lysine for discrimination of tryptophan enantiomers, [89] laccase for detection of phenolic compounds, [90] calix [8]arene/ folic acid for sensing of cancer cells, [91] and many others. [62,92] These tailored mioeties could seamlessly match the current bioelectronics chemistry.…”

Section: Secondary Modificationmentioning

confidence: 99%

Flexible Polydopamine Bioelectronics

Jin

Yang

Shi

et al. 2021

Adv Funct Materials

131

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Flexible bioelectronics have attracted increasing research interests due to their wide range of potential applications in human motion detection, personal healthcare monitoring, and medical diagnosis. Recently, design and fabrication strategies integrated with mussel-inspired polydopamine (PDA) have demonstrated many appealing properties, which meet the structural and functional requirements of high-performance flexible bioelectronics. The inherent multiple reactive sites and hierarchical interactions within PDA can promote the total electrochemical activities, self-healing, surface activation, and biocompatibility of the composite system. This review paper strives to provide a comprehensive overview on this emerging area, including the fabrication methodology, the structural and functional contributions of PDA on the whole composites, and various applications of PDA-based flexible bioelectronics. The current challenges and future outlook in this field are also extensively discussed at the end. This paper aims to serve as a guideline in this emerging area and provide new inspirations toward next-generation integrated multifunctional flexible PDA bioelectronics with a broad range of healthcare applications.

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Electrochemical sensor for cancer cell detection using calix[8]arene/polydopamine/phosphorene nanocomposite based on host−guest recognition

Cited by 29 publications

References 39 publications

Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells

Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells

Facile preparation of a cost-effective platform based on ZnFe2O4 nanomaterials for electrochemical cell detection

Flexible Polydopamine Bioelectronics

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