Electrochemical Studies and Square‐Wave Adsorptive Stripping Voltammetry of Spironolactone Drug

Al-Ghamdi, Ahmad; Alghamdi, Ali F.; Al-Omar, Mohammed A.

doi:10.1080/00032710701746832

Cited by 24 publications

(13 citation statements)

References 11 publications

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“…In the CV, a small reduction peak current at high ν corresponding to peak I was noticed. Thus, it can be concluded that, the reduction step undergoes a very rapid follow-up chemical reaction [13] , [14] . The dependence of the CV response on analyte concentration at pH 9.0 showed no significant changes on the cathodic current of the observed cathodic peak at −1.20 V, indicating that the electrochemical process is a typical of ECE type electrochemical mechanism [19] .…”

Section: Resultsmentioning

confidence: 99%

“…The selectivity and detection limit of polarographic method [13] are not compatible with the low level of SP residues in wastewater. On the other hand, in SW-ACSV method [14] , peak resolution and selectivity of the observed cathodic peak at −1.15 V were also not compatible for analysis of SP residues in wastewater. In continuation to our previous work on analysis of drug residues in wastewater [15] , this paper reports the redox behavior of SP drug in an attempt to develop a low cost and selective differential pulse cathodic stripping voltammetry (DPCSV) method for analysis of SP residues in wastewater and drug formulations.…”

Section: Introductionmentioning

confidence: 84%

“…Polarographic [13] and square-wave adsorptive cathodic stripping voltammetric (SW-AdSV) [14] have been developed for SP determination in drug formulations at dropping mercury electrode (DME) and hanging mercury drop electrode (HMDE) at pH 2–3, respectively. The selectivity and detection limit of polarographic method [13] are not compatible with the low level of SP residues in wastewater.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry

El-Shahawi

Bashammakh

Al-Sibaai

et al. 2013

Journal of Pharmaceutical Analysis

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The redox behavior of spironolactone (SP) drug in Britton–Robinson (BR) buffer of pH 2–11 was investigated by differential pulse cathodic stripping voltammetry (DPCSV) and cyclic voltammetry (CV) at hanging mercury dropping electrode (HMDE). At pH 9–10.5, the DPCSV of SP drug showed two cathodic peaks at −1.15 and −1.38 V at the HMDE vs. Ag/AgCl reference electrode. In the CV, at pH 9–10, the dependence of the cathodic peak current, Ip,c and peak potential, Ep,c of the second peak (Ep,c2) on the scan rate (ν) and on the depolizer (SP) concentrations was typical of an electrode coupled (EC) chemical reaction type mechanism. The plot of Ip,c at −1.380 V of the DPCSV vs. SP concentration at pH 9 was linear over the concentration range of 1.2×10−10−9.6×10−7 M. The lower limit of detection (LLOD) and limit of quantification (LOQ) of the drug were 1.1×10−11 and 4.14×10−11 M, respectively. The method was successfully applied for the analysis of SP residues in industrial wastewater, in pure form (98.2±3.1%) and in drug formulations e.g. Aldactone® tablet (98.35±2.9%).The method was validated by comparison with HPLC and the official data methods.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry

El-Shahawi

Bashammakh

Al-Sibaai

et al. 2013

Journal of Pharmaceutical Analysis

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“…Hang ng mercury drop electrode [36] 0.2 Not reported 8 × 10 -7 to 8 × 10 -5 mol L -1 Not reported Chem lum nescence Tr s(1,10 phenanthrol ne) ruthen um(II)-Ce(IV) system [37] 0.5 Not reported 7 × 10 -7 to 6 × 10 -5 mol L -1 Not reported Spectrophotometr c Ion-pa r w th bromothymol blue [38] 2.92 nmol L -1 310.6 µA/mmol L -1 0.8 µmol L -1 to 360 µmol L -1…”

Section: Methods Validationmentioning

confidence: 99%

Synthesis of neodymium-iron nanoperovskite for sensing applications of an antiallergic drug

Atta¹,

BinSabt²,

El-Ads³

et al. 2017

Turk J Chem

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A facile route was used for the fabrication of NdFeO 3 (NF) perovskite. The orthorhombic structure of single phase nanocrystalline NdFeO 3 perovskite was confirmed by different characterization techniques: XRD, FTIR, TEM, BET, SEM, and EDAX. The nanoperovskite was successfully used as a sensor component with a carbon paste electrode (CpE) for the determination of ketotifen in pharmaceutical formulations. Ketotifen, an antiallergic drug, is utilized for the treatment of asthma attacks, rhinitis, skin allergies, and anaphylaxis. Sodium dodecyl sulfate (SDS) was employed in a surface assembly mode to improve the sensitivity of the sensor response. The proposed sensor, NdFeO 3 in situ modified carbon paste electrode in the presence of SDS (NFMCpE-SDS), showed a higher current response towards ketotifen oxidation compared to other surfaces. The enhanced signal response is attributed to the catalytic properties of the sensor and the relative increase in surface area. A linear relationship between the oxidation peak current and ketotifen concentration was obtained in the concentration range of 0.8 µ mol L −1 to 360 µ mol L −1. The surface showed long-term stability of 1 month of operation and the limits of detection and quantification of ketotifen were 2.92 nmol L −1 and 9.71 nmol L −1 , respectively, with high sensitivity of 311 µ A/mmol L −1. The composite electrode proved to be selective for drug sensing in the presence of different interfering species and applicable for drug determination in commercial tablets, human serum, and urine.

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“…The advantage of the application of an SW waveform was documented by trace analysis of several drugs that exhibited adsorption at the electrode surface. [18][19][20][21] The SW response markedly depended on the parameters of the excitement signal. In order to obtain the maximum peak current, the optimum instrumental conditions (frequency of 125 Hz, scan increment of 5 mV and pulse amplitude of 50 mV) were applied in the further work.…”

Section: Adsorptive Character Of the Drugmentioning

confidence: 99%

Electrochemical study of varenicline adsorptive behaviour and its interaction with DNA

Radulović¹,

Aleksic²,

Kapetanović³

2012

JSCS

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The electrochemical behaviour of novel nicotinic α4β2 subtype receptor partial agonist varenicline (VAR) which is used for smoking cessation, was investigated in Britton-Robinson buffers (pH 2.0-12.0) by cyclic, differential pulse and square wave voltammetry at a hanging mercury drop elctrode. The influence of pH, scan rate, concentration, accumulation potential and time on peak current and potential suggested that in alkaline media the redox process was adsorption controlled. Also, the experimental value of surface coverage, G = 1.03´10-10 mol cm-2, was used to determine the conditions when VAR was fully adsorbed at the electrode surface. Having in mind potential high toxicity of VAR due to the presence of quinoxaline structure, its interaction with DNA was postulated, and studied when both compounds were in the adsorbed state at modified HMDE. Using adsorptive transfer technique, the changes in potential and decrease in normalized peak currents were observed. The estimated value of the ratio of surface-binding constants indicated that the reduced form of VAR interacted with dsDNA more strongly than the oxidized form. Subtle DNA damage under conditions of direct DNA-VAR interaction at room temperature was observed. The proposed type of interaction was an intercalation. This study used simple electroanalytical methodology and showed the potential of DNA/HMDE biosensor for investigation of genotoxic effects

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Electrochemical Studies and Square‐Wave Adsorptive Stripping Voltammetry of Spironolactone Drug

Cited by 24 publications

References 11 publications

Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry

Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry

Synthesis of neodymium-iron nanoperovskite for sensing applications of an antiallergic drug

Electrochemical study of varenicline adsorptive behaviour and its interaction with DNA

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