Electrochemical studies for the determination of an antibiotic drug, d-cycloserine, in pharmaceutical and human biological samples

Abstract

An antibiotic drug, d-cycloserine (CYS), in phosphate buffer at different pH values was electrochemically studied using a gold electrode. A well-resolved, irreversible, diffusion-controlled voltammetric peak was obtained at 0.873 V in a pH 9.2 phosphate buffer solution with an ionic strength of 0.2 M. The experimental conditions, such as the solution pH and scan rate, were optimized. The pH dependence suggested that equal numbers of protons and electrons were involved in the electrochemical oxidation of CYS. A plausible oxidation mechanism was proposed. Under the selected conditions, the dependence on the concentration of CYS revealed that the detection limit for CYS was 3.3 × 10 −8 M for differential pulse voltammetry and 4.91 × 10 −8 M for square wave voltammetry. The proposed method was successfully applied to the determination of CYS in drug capsules and urine samples. The electrode exhibits good reproducibility and stability. In addition, the influence of various foreign species was studied.

Computational Design and Application of Molecularly Imprinted/MWCNT Based Electrochemical Sensor for the Determination of Silodosin

“…The slope is near to half the theoretical value of 0.059 in equation ( 5), indicating that the ratio of y/n is very close to half." Thus, it can be concluded that two electrons and one proton were involved in the electron transfer which agrees with the mechanism previously reported for some structure similar compounds [63,64]. Scheme 1 represents the possible mechanism for anodic oxidative behavior of SLD, which can involve the oxidation of alkoxybenzene into quinone by undergoing a 2e,1H + oxidation as previously reported for Tamsulosin (TAM), another structurally similar compound [65,66].…”

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

“…Some working electrodes frequently used in voltammetric determinations are glassy carbon, graphite pencil, boron‐doped diamond, silver solid amalgam, silver, gold, carbon paste, bismuth electrodes, hanging mercury drop electrode (HMDE), etc. . Among these electrodes, HMDE has been used to determination of several inorganic and organic analytes.…”

Composite Drug Delivery System Based on Amorphous Calcium Phosphate–Chitosan: An Efficient Antimicrobial Platform for Extended Release of Tetracycline

“…In the last few years, the design and methodology to obtain such systems have developed considerably. Different coating methods (e.g., cold spraying [9], dip coating [10], electrochemical methods [11], electrophoretic deposition [12], magnetron sputtering [13], photochemical oxidation [14], and matrixassisted pulsed laser evaporation (MAPLE) [15][16][17]) were applied for incorporating various antibiotics (e.g., gentamicin [18], vancomycin [19], tobramycin [20], rifampicin [21,22], or tetracycline hydrochloride [23,24]) onto bioactive surfaces.…”