Electrochemical studies of DNA interaction and antimicrobial activities of MnII, FeIII, CoII and NiII Schiff base tetraazamacrocyclic complexes

Kumar, Anuj; Vashistha, Vinod Kumar; Tevatia, Prashant; Singh, Randhir

doi:10.1016/j.saa.2016.12.011

Cited by 35 publications

(19 citation statements)

References 30 publications

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“…Infrared studies: The IR spectra of macrocyclic complexes showed no characteristic band of >C=O of acetyl acetone and -NH2 band for primary amine suggesting the complete condensation. A weak absorption band in the region of 2900 cm -1 resulted by C-H(-CH3) stretching vibration [15] and medium intensity band at 1580, 1500, 1450 cm -1 for the C-H(-CH3) bending vibration. The absorption band in the region of 1632-1675 cm -1 resulted from aromatic C=C stretching vibration.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and Electrochemical Studies of Hexamethyldibenzotetraaza N4-Macrocyclic Complexes of Ni(II) and Cu(II) Metal ions

et al. 2019

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Hexamethyldibenzotetraaza[14]annulene type macrocyclic complexes of Ni(II) and Cu(II) have been synthesized by template method. These macrocyclic complexes were characterized by molar conductance, elemental analysis, IR, UV-visible, mass spectra and cyclic voltammetry. On the basis of electronic studies saddle shape distorted octahedral structure have been assigned to these macrocyclic complexes. The redox behaviour of Ni(II) and Cu(II) macrocyclic complexes showed reversible and quasi-irreversible redox process that supported by the ipc/ipa ratio which is in good agreement with Randles-Sevcik equation. These macrocyclic complexes were also studied for the antimicrobial activity against E. coli, P. aeruginosa, B. subtilis, S. aureus and C. albicans compared with gentamycin as standard drug.

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Section: Resultsmentioning

confidence: 99%

“…Electrochemical studies have been carried out by cyclic voltammetry. The formation of reversible and quasi-irreversible redox couple is responsible for kinetic stability of redox couple [12,13].…”

Section: Synthesis and Electrochemical Studies Of Hexamethyldibenzotementioning

confidence: 99%

Synthesis and Electrochemical Studies of Hexamethyldibenzotetraaza N4-Macrocyclic Complexes of Ni(II) and Cu(II) Metal ions

et al. 2019

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“…Synthesis of macrocyclic complexes. The Schiff’s base tetraazamacrocyclic complexes {[M(L)X 2 ]; M = Co(II), Ni(II), and X = C1 − } were synthesized by following the reported method [ 20 , 21 ]. Briefly, triethylenetetraamine (1 mol, 0.146 g), 2,6-diacetyl pyridine (1 mol, 0.163 g) and cobalt(II)chloride hexahydrate (1 mol, 0.237 g) were mixed in 50 mL MeOH in round bottomed flask.…”

Section: Methodsmentioning

confidence: 99%

“…This is particularly significant for those planned as models for the functional metalloprotein sites [2]. The redox potential of these substances (E 1/2 for ML n+ /ML (n + 1)+ ) is the main factor that not only represents the comparative thermodynamic stabilities of the oxidation states of central metals, and also defines the chemical reactivity of such complexes in redox systems [3,4]. Recently, transition metals such as cobalt and nickel have been used for synthesis of complexes with diverse ligand and studied for their diverse properties [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Co(II) and Ni(II) Asymmetric Tetraazamacrocyclic Complexes and Their Electrochemical and Antimicrobial Studies

Vashistha

Kumar

2020

Russ. J. Inorg. Chem.

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In this work, the synthesis of two asymmetric Co(II) and Ni(II) tetraazamacrocyclic complexes has been carried out by the template method. The synthesized complexes have been characterized by various analytical techniques such as elemental analysis, UV-Vis, IR, and Mass spectroscopy. The mass spectral studies of the complexes have been found to agree with theoretically calculated values. The calculated molar conductance values for the two complexes suggest a non-electrolytic nature of the complexes. A distorted octahedral geometry has been assigned to both the complexes as shown by spectral studies. Results of the electrochemical studies of the complexes through cyclic voltammetry indicate that metal centers can be differentiated by their intrinsic redox systems, viz. Co(III)/Co(II), Co(II)/Co(I) and Ni(II)/Ni(I). Moreover, antimicrobial activities of complexes have been investigated against E. coli, S. aureus, B. subtilis, and P. aeruginosa pathogens. The results of these studies indicate that both the complexes exhibit significant antimicrobial activity against the tested pathogens.

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“…Based on the fact that the mixed solutions of CT-DNA and EB show a strongly fluorescence emission and the paper complexes have no fluorescence either alone or in the presence of CT-DNA in the buffer, the quenching experiments were employed by adding aliquots of 0-80 μM solutions of the Ni(II) complexes to the solution containing 10 μM EB and 11 μM CT-DNA in Tris-HCl buffer. [37][38][39] In this process, the strong fluorescence of EB-DNA can be quenched by the replacement of EB with complexes, the emission spectra of EB bound to DNA in the absence and presence of the complexes are shown in Figure 7. The Stern-Volmer equation I 0 /I = 1 + K[Q] was used to determine the quenching constant, [40] where I 0 and I are the emission intensities in the absence and the presence of the complexes, respectively.…”

Section: Fluorescence Spectroscopic Studiesmentioning

confidence: 99%

Template‐Directed Synthesis of Two Dinuclear Ni(II) Complexes together with Their Interconversion, Crystal Structures and DNA‐Binding Studies

Wang

Liu

et al. 2020

ChemistrySelect

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Dinuclear Ni(II) macrocyclic complex A ([Ni2L1OAc]ClO4⋅CH3OH⋅H2O) and dinuclear Ni(II) acyclic complex B ([Ni2L2](ClO4)2) were synthesized by condensation between H2L (3,3′‐(ethane‐1,2‐diylbis(benzylazanediyl))bis(methylene)bis(2‐hydroxy‐5‐methyl‐benzaldehyde)) and different molar equivalent 1,3‐propanediamine in the presence of Ni(II) ions. The structures of complexes were characterized by IR spectroscopy, elemental analysis, electrospray mass spectra and X‐ray single crystal diffraction. In complex A, the Ni(II)‐Ni(II) distance was 2.9413(7) Å, bridged by two phenolic oxygens and an acetate anion, while in complex B, it was 3.0540(1) Å, only bridged by two phenolic oxygens. The calf thymus DNA (CT‐DNA) binding ability was studied through spectroscopic and electrochemical methods, the corresponding binding constant for complexes A and B were 6.45×104 M−1 and 8.65×104 M−1, respectively. The MS revealed that B can transform to A by adding more H2L, and A cannot transform to B in the presence of excess 1,3‐propanediamine.

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Electrochemical studies of DNA interaction and antimicrobial activities of MnII, FeIII, CoII and NiII Schiff base tetraazamacrocyclic complexes

Cited by 35 publications

References 30 publications

Synthesis and Electrochemical Studies of Hexamethyldibenzotetraaza N4-Macrocyclic Complexes of Ni(II) and Cu(II) Metal ions

Synthesis and Electrochemical Studies of Hexamethyldibenzotetraaza N4-Macrocyclic Complexes of Ni(II) and Cu(II) Metal ions

Synthesis of Co(II) and Ni(II) Asymmetric Tetraazamacrocyclic Complexes and Their Electrochemical and Antimicrobial Studies

Template‐Directed Synthesis of Two Dinuclear Ni(II) Complexes together with Their Interconversion, Crystal Structures and DNA‐Binding Studies

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